Sentences with phrase «human pathology studies»
Human pathology studies suggest that tumor cells invade collectively as strands, cords and clusters of cells into the stroma, which is dramatically reorganized during cancer progression.
https://science.institut-curie.org/ Not exact matches
Assagioli has an appreciation for the way in which the intensive study of pathology by psychoanalysis and depth psychology has enlarged and deepened our understanding of the human psyche.
Evidence from animal and small - scale human studies suggests that pioglitazone may prevent or reverse Alzheimer's - related pathology and symptoms.
«Before this study, it was not known if it is possible to produce sufficient numbers of these cells and successfully use them to remuscularize damaged hearts in a large animal whose heart size and physiology is similar to that of the human heart,» said Dr. Charles Murry, UW professor of pathology and bioengineering, who led the research team that conducted the experiment.
The physician - scientist may study the same properties of the same molecule but for a different reason: because he or she believes that those studies will provide information on the fundamental pathology of a disease or insight into human biology that will provide a better understanding of healthy versus diseased states.
The study, led by Dr. Maximilian Muenke of the National Human Genome Research Institute in Bethesda, Maryland, brings scientists closer to understanding how ADGRL3 contributes to risk by providing functional evidence that implicates a transcription factor in the pathology of the disorder.
«We think that for the first time, we have a mouse model of anorexia that closely resembles the conditions leading up to the disease in humans,» said study leader Lori Zeltser, PhD, associate professor of pathology & cell biology and a researcher in the Naomi Berrie Diabetes Center.
«Very few studies have investigated Alzheimer's disease pathology in chimpanzees, the species closest in phylogeny and most genetically related to humans,» said senior author Mary Ann Raghanti, Ph.D., associate professor and interim chair of anthropology at Kent State.
The next step, says Makoto Kuro - o, an assistant professor of pathology at the University of Texas Southwestern Medical Center, is to study Klotho in humans.
Results of previous studies in mice of bexarotene's effect on AD have been mixed, and none of those studies were done in mice that carry a human APOE gene and also develop progressive, AD - like pathology.
«Very few studies have investigated Alzheimer's disease pathology in chimpanzees, the species closest in phylogeny and most genetically related to humans,» said senior author Dr. Mary Ann Raghanti, associate professor and interim chair of anthropology at Kent State.
The brains of aged chimpanzees, our closest living relatives, show pathology similar to the human Alzheimer's disease (AD) brain, according to a new, multi-institution research study.
«It's probably the single most common gene fusion in human cancer,» said study co-leader Antonio Iavarone, MD, professor of neurology and of pathology and cell biology (in the Institute for Cancer Genetics) at CUMC.
Monogenic diseases are often lacking of physiological human cellular models dedicated to the study of the molecular mechanism implicated in the development of the pathology.
The unit study macromolecules that are central in basic processes of cellular life, as well as for specific human pathologies.
In this study, we have used a multidimensional approach including high - magnification and super-resolution microscopy, cerebro - spinal fluid (CSF) mass spectrometry analysis and ELISA to investigate the Aβ pathology and its associated cognitive impairments, in a novel transgenic rat model overexpressing human APP.
Most studies test drugs before pathology is present, which is preventive rather than therapeutic and may be the reason drugs don't transfer from animal studies to humans.
Dr. Pfaff has developed a novel embryonic - stem cell - based model of SMA that phenocopies the pathology of human SMA, and can be used to study the basis of the disease and screen for compounds that might increase survival of motor neurons.
«Basically, this study shows that the genetic makeup of individual human embryonic stem cell lines is unique in the numbers of copies of certain genes that may control traits and things like disease susceptibility,» said Teitell, who also is an associate professor of pathology and laboratory medicine and a researcher at UCLA's Jonsson Comprehensive Cancer Center.
These observations have highlighted their value as model organisms to study the etiology of human neurodevelopmental pathologies.
She joined the Pillai lab as a post-doctoral research fellow in 2016 and continues to enjoy her work both treating patients with primary immunodeficiency in the clinic and studying the bridging gap between human primary immunodeficiency disorders and the development of autoimmune disease pathology in the lab.
The present study was aimed at measuring non-cognitive behaviors such as aggression and relevant pathologies such as plaque load and distribution in mutant mice expressing human APP, namely the APP / PS1 (APPsw / PS1 (m146L)-RRB- and TASD41 (hAPP751 with the London V717I9 / Swedish double mutation K670M / N671L).
Experimental studies and a growing body of evidence has emerged demonstrating that synthetic α synuclein fibrils (both human and murine) are capable of «seeding» and propagating α synuclein pathology not only in α synuclein transgenic mouse models but importantly in non-transgenic (WT) neuronal cultures and mice (Luk, K.C. et al., 2012a; Luk, K.C. et al., 2012b; Volpicelli - Daley, L.A. et al., 2014).
Employs mouse models of human eye disease to study gene function and mechanisms underlying disease pathology.