Further research based on autopsy specimens and animal experiments will be needed to clarify the relationship and determine if the patients with MRI
hyperintensity in their brains have symptoms.
The precise clinical ramifications of hyperintensity are not known, but
hyperintensity in the DN has been associated with multiple sclerosis, while hyperintensity of the GP is linked with hepatic dysfunction and several diseases.
Spatial distribution of white - matter
hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy aging.
Weekly alcohol consumption, brain atrophy, and white matter
hyperintensities in a community - based sample aged 60 to 64 years
Not exact matches
Patients showing gadolinium
in the vitreous chamber at the later timepoint tended to be of older age, have a history of hypertension, and have more bright spots on their brain scans, called white matter
hyperintensities, that are associated with brain aging and decreased cognitive function.
Authors examined the association between SVD and AD pathology by looking at magnetic resonance imaging (MRI)- based microbleeds (MB), white matter
hyperintensities (WMH) and lacunes (which are measures for SVD) along with certain protein levels
in cerebrospinal fluid (CSF) which reflect AD pathophysiology
in patients with AD, VaD and healthy control patients.
The increases
in signal
hyperintensity persisted even after the injections stopped.
Over time, «significant and persistent» MRI abnormalities (called T1 - weighted signal
hyperintensities) developed
in the brains of rats receiving the linear GBCA, gadodiamide.
However,
in recent years, clinicians
in Japan noticed that patients with a history of multiple administrations of Gd - CM showed areas of high intensity, or
hyperintensity, on MRI
in two brain regions: the dentate nucleus (DN) and globus pallidus (GP).
Dr. Kanda noted that because patients with multiple sclerosis tend to undergo numerous contrast - enhanced brain MRI scans, the
hyperintensity of the DN seen
in these patients may have more to do with the large cumulative gadolinium dose than the disease itself.
«The
hyperintensity of DN and GP on unenhanced T1WI may be due to gadolinium deposition
in the brain independent of renal function, and the deposition may remain
in the brain for a long time,» Dr. Kanda suggested.
The researchers estimated that a one percent increase
in aortic arch pulse wave velocity (
in meters per second) is related to a 0.3 percent increase
in subsequent white matter
hyperintensity volume (
in milliliters) when all other variables are constant.
«Our results demonstrate that aortic arch pulse wave velocity is a highly significant independent predictor of subsequent white matter
hyperintensity volume and provides a distinct contribution — along with systolic blood pressure, hypertension treatment, congestive heart failure and age —
in predicting risk for cerebrovascular disease,» Dr. King said.
Kato T, Murashita J, Kamiya A, Shioiri T, Kato N, Inubushi T. Decreased brain intracellular pH measured by 31P - MRS
in bipolar disorder: a confirmation
in drug - free patients and correlation with white matter
hyperintensity.
Negativity can come
in the form of cynicism, criticism, whining, attacking, pessimism, discontent, perfectionism, and
hyperintensity.