Sentences with phrase «ii clinical»

Different combinations of the depression questions were evaluated against Beck Depression Inventory II clinical cutoff values.

Worked in a Phase I / II clinical trials research laboratory that focuses on the development of antigen - specific cytotoxic T - lymphocytes for adoptive cellular immune therapies in children and adults

Hands - on Group leader / Associate director to support DMPK - clinical pharmacolgy of drug candidate from drug discovery to Phase I / II clinical studies

Phase II clinical trial of combination chemotherapy with dexamethasone for lymphoma in dogs.

There is a 1.2 M position of shorted shares and they are working hard to create a flush out prior the phase II clinical interim data presentation on the 17th November.

Our board of directors considered the fact that we were in the early stages of considering strategic alternatives that could create more value for shareholders than the Tang Capital proposal, that the directors believed that continuing to execute on our strategic plan, which included conducting the PROSPECT II clinical trial and continuing to develop our Renova ™ Cortical Stimulation System, could ultimately create more value for shareholders than the Tang Capital proposal, and that management had prepared an informal liquidation analysis which showed that the estimated liquidation value of Northstar at that time was greater than the price in the Tang Capital proposal.

Our board of directors also considered the current dire macroeconomic conditions, which had materially worsened since mid-2008, when we decided to proceed with our strategic operating plan and our PROSPECT II clinical trial, and the state of the medical device industry generally.

A randomized phase II clinical trial on the ability of strawberries to reverse the progression to esophageal cancer.

Currently, the CDK9 inhibitor flavopiridol is being evaluated in several phase I and II clinical trials for its anti-cancer effects either as a single agent or in combination with other drugs in treatment of esophageal cancer, B - cell chronic lymphocytic leukemia, endometrial carcinoma, recurrent / metastatic squamous cell carcinoma and most relevantly, previously treated locally advanced or metastatic breast cancer (http://www.cancernetwork.com/review-article/current-clinical-trials-flavopiridol/page/0/2).

Reykjavik, ICELAND, May 10, 2005 — deCODE genetics (Nasdaq: DCGN) today announced the publication of a landmark article by a team of its scientists presenting the results of Phase II clinical studies of DG031, the company's lead compound being developed for the...

Ohio State is one of only 41 National Cancer Institute - designated Comprehensive Cancer Centers and one of only four centers funded by the NCI to conduct both phase I and phase II clinical trials on novel anticancer drugs.

Reykjavik, ICELAND, May 18, 2005 — deCODE genetics (Nasdaq: DCGN) today announced that it has begun dosing of patients in a Phase II clinical trial in asthma.

Acucela is another company with a drug candidate for Stargardt's disease in Phase II clinical trials.

RV 172: A Phase I / II Clinical Trial to Evaluate the Safety and Immunogenicity of a Multiclade HIV - 1 DNA Plasmid Vaccine, VRC - HIVDNA016 -00-VP, Boosted by a Multiclade HIV - 1 Recombinant ADENOVIRUS - 5 Vector Vaccine, VRC - HIVADV014 -00-VP in HIV Uninfected Adu

Treating women with olaparib, a new type of experimental drug called a PARP inhibitor, after their initial cancer treatment, may help prevent their ovarian cancer from coming back, according to a phase - II clinical trial led by UK scientists.

One such prototypic antibody, the IgG1kappa mAb 11 - 1F4, has now been chimerized and is undergoing GMP production for an eventual phase I and II clinical trial in patients with AL amyloidosis.

CONCLUSIONS: These results have led to the decision to produce GMP - grade c11 - 1F4 for a Phase I / II clinical trial in patients with primary (AL) amyloidosis where the effectiveness of the reagent could be determined.

Results from Phase I and Phase II clinical trials were encouraging, with significant vision improvements reported for some patients.

Dr. Gajewski has developed experimental vaccines against melanoma that are currently in Phase II clinical trials in a handful of patients at the University of Chicago Hospitals.

Towards the clinical translation of intra-articular injection of MSCs, the group of Kang Sup Yoon at the Seoul National University College of Medicine, Seoul, Korea report on their a proof - of concept phase I / II clinical trial intra-articular injection of autologous adipose tissue derived mesenchymal stem cells (AD MSCs)[6].

[44] Two other phase II clinical trials evaluated the efficacy of imatinib in patients with melanoma — including mucosal melanomas — harboring KIT mutations and / or amplifications, with a subset of cases involving mucosal primaries, and both found a disease control rate of approximately 50 %.

Finally, the plans for the future development of the vaccine and the next steps to phase II clinical trial were presented.

To ensure engraftment without severe GVHD, O'Donnell has conducted Phase I / II clinical trials since 1999 in which a half - matched transplant is performed and then a high dose of chemotherapy is administered to the patient three days later.

ARRY - 520, a novel selective kinesin spindle protein (KSP) inhibitor showed promising clinical activity both alone and combined with low - dose dexamethasone in a phase II clinical trial in patients with relapsed and refractory multiple myeloma.

Another modified peptide POL6326 is in phase II clinical trial in hematopoietic stem cell mobilization in multiple myeloma [128].

Stein E. Results of phase I / II clinical trials with ezetimibe, a novel selective cholesterol absorption inhibitor.

We are now moving this discovery into Phase II clinical trials (FDA approved) in patients suffering ischemic damage to the heart.

deCODE genetics (Nasdaq: DCGN) today announced positive results from its preliminary Phase II clinical trial (Phase IIa) of Cephalon Inc.'s (Nasdaq: CEPH) CEP - 1347 in asthma.

Under his direction, plasmid DNA, CAR - T - cells, regulatory T - cells, engineered stem cell grafts and gene modified hematopoietic stem cell products have been manufactured and released for use in Phase I / II clinical trials.

These nanoparticles are currently being tested in a number of phase - II clinical trials.

She is CEO of PsychoGenics Inc., a profitable preclinical CNS service company, CEO of PGI Drug Discovery LLC, a company engaged in psychiatric drug discovery with three partnered Phase II clinical programs and Adjunct Associate Professor of Neuroscience at Mount Sinai School of Medicine, Dr. Leahy has more than 25 years of experience in drug discovery, clinical develop and business development for pharmaceutical and biotechnology companies, including extensive knowledge of technology assessment, licensing, mergers and acquisitions, and strategic planning.

Finch expects to begin enrolling for a Phase II clinical trial to evaluate the safety and efficacy of FIN - 403 for the prevention of recurrence in recurrent C. difficile patients in the second half of 2017.

Lysogene successfully completed its phase I / II clinical trial of gene therapy in MPS IIIA and plans its phase II / III registrational trials... Read More

We offer trials for childhood brain tumors, solid tumors, hematological malignancies, infectious diseases, and hematology, including Phase I / II clinical trials.

Recently two phase II clinical trials were initiated by treating HGPS patients with Farnesyltransferase inhibitors (FTIs) and / or the combination of Zoledronate and Pravastatin to prevent or delay the gravest infringements of the disease.

However, in this Phase II clinical trial, designed to prospectively evaluate the safety and effectiveness of ACHT for patients with HIV - related lymphoma, researchers discovered that this population had no greater likelihood of developing these complications compared to those without the virus.

Neuroblastoma tumors shrank, some dramatically, in 80 percent of newly diagnosed, young, high - risk patients enrolled in a Phase II clinical trial that included an experimental monoclonal antibody.

The initiative would rush these through to phase II clinical trials — the stage at which drugs are given to larger groups of people, but before the huge phase III trials that represent a drug's final hurdle before reaching the market.

This prospective, single - arm, phase II clinical trial was conducted to evaluate the safety, feasibility, and efficacy of induction chemotherapy followed by SABR in 34 patients who had biopsy - proven PDA.

The targeted therapy rucaparib, which has demonstrated robust clinical activity in ovarian cancer patients with a BRCA mutation, also showed promise in previously treated pancreatic cancer patients with the mutation, according to results from a phase II clinical study.

The drug has completed Phase II clinical trials in the U.S. and Phase III in Japan for preventing diabetic neuropathy and was found to have no major side effects.

Researchers at Massachusetts Eye and Ear / Harvard Medical School and the University of Crete have conducted a phase I / II clinical trial investigating the efficacy of statins (cholesterol - lowering medications) for the treatment of patients with the dry form of age - related macular degeneration (AMD)-- the leading cause of blindness in the developed world.

Hence, a total of 90 patients from nine centers were randomly assigned to one of two study arms for the phase II clinical trial: the first taking capsules of olaparib (400 mg twice daily) and the other taking a combination of the two drugs (200 mg olaparib in capsule - form twice daily and 30 mg tablets of cediranib once daily).

The safety study sets the stage for phase II clinical trials looking at whether high dose vitamin C is effective at extending overall lifespan and quality of life for patients undergoing radiation and chemotherapy.

In a small phase I and II clinical trial, Johns Hopkins researchers and colleagues elsewhere found that the high - fat, low - carbohydrate ketogenic diet was a safe and effective treatment option for the majority of adults experiencing a relatively rare, often fatal and always severe form of epilepsy marked by prolonged seizures that require medically induced comas to prevent them from further damaging the body and the brain.

Patients with advanced NSCLC with the EGFR mutation, with or without the T790M resistance mutation, were enrolled in the phase I / II clinical trial in centres in Europe, Australia and the USA; enrolment of patients for the phase I part of the study began in March 2012, and for the phase II part in August 2013.

A new drug that targets not only common cancer - causing genetic mutations in patients with non-small cell lung cancer (NSCLC), but also a form of the mutation that causes resistance to treatment, has shown promising results in patients in a phase I / II clinical trial.

The study — conducted by the Clinical Investigator Collaborative, a multi-centre, Phase II clinical trials group supported by the Allergy, Genes and Environment Network (AllerGen)-- recruited 31 patients over five sites across Canada.

The findings of this promising phase II clinical trial have been published in the International Journal of Radiology Oncology.

Worse, many promising drug candidates fail in phase II clinical trials when their efficacy is put to the test.