Sentences with phrase «identification of genes associated»

Wistar discoveries have led to the development of vaccines for rabies, rubella, and rotavirus, the identification of genes associated with different types of cancer, the development of monoclonal antibodies, and other significant research technologies and tools.

Identification of genes associated with local aggressiveness and metastatic behavior in soft tissue tumors.

He was a post-doctoral fellow at the Children's Hospital of Eastern Ontario in Ottawa, working on identification of genes associated with human spinal muscular atrophy.

Not exact matches

But it can also make identification of the size - associated genes difficult.

«The identification and initial validation of a highly accurate 5 - gene pancreatic cancer biomarker panel that can discriminate late and early stages of pancreatic cancer from normal pancreas and benign pancreatic lesions could facilitate early diagnosis of pancreatic cancer,» said co-senior author Roya Khosravi - Far, PhD, Associate Professor of Pathology at BIDMC.

The enrichment factor described how frequently cancer associated genes were identified compared to the frequency of identification that one could expect by pure chance.

The study results challenge the current paradigm of microarray data analysis and suggest that the new method may improve identification of cancer - associated genes.

Frequently, the term cloning is misleadingly used to refer to the identification of the chromosomal location of a gene associated with a particular phenotype of interest.

GOMiner — To provide additional statistical stringency to the identification of potential targets, we then analyzed the data sets generated by the SAM - RS analysis of the microarray data for hypoxia - associated coregulation of multiple, functionally related genes.

He has made important contributions to the understanding of the molecular basis of retinal and eye development, and to the identification of genes and processes associated with inherited retinal degenerations.

Conclusions: The identification of gene expression alterations as a function of hypoxia and recovery from hypoxia is important to understand the molecular mechanisms underlying retinal dysfunction associated with a variety of diseases.

«If we can establish a link between abnormal forms of this gene and ADHD, it could provide us with a powerful new tool for precise diagnosis and early identification of children at risk, and a signpost toward designing better drug treatment,» said Ed Cook, associate professor of psychiatry and of pediatrics at the University of Chicago and lead author of the report.

Dr. Eng and team create scoring system to facilitate identifying individuals to be referred to PTEN gene testing Researchers have discovered a method for more precise identification of individuals who should undergo testing for genetic mutations of the tumor suppressor gene PTEN, which associates with a variety of conditions including several types of cancers.

Careful manual annotation of the human reference sequence provides a solid basis for the identification of disease - associated genes.

Linkage and candidate gene studies have been highly successful in the identification of genes that cause the monogenic variants of diabetes and, although progress in the more common forms of T2D has been slow, a number of genes have now been reproducibly associated with T2D risk in multiple studies.

As one example of his contribution, Wahl's team reported the first identification, isolation and characterization of mouse fetal mammary stem cells and their associated gene expression profiles.

Some of the team's most significant findings since 2009 were the identification of a gene mutation associated with blood cancers and the discovery of chromosomal crisis where the genome can be shattered into hundreds of fragments in a single cellular catastrophe.

The immunopurification (IP) of Argonaute (Ago), a central component of the RISC in the human and mouse, followed by microarray analyses (Ago IP / microarray method) makes it possible to isolate any Ago - associated miRNAs and mRNAs without relying on the mechanism of regulation (i.e. mRNA decay or translational suppression), or sequence conservation, enabling a comprehensive identification of the miRNA - target genes in an unbiased manner.

Collectively these tools provided a robust means to interrogate tumor specimens for changes to the genome, which lead to identification of genomic regions and genes associated with cancer.

The test identifies seven mutations in three different genes which permits identification of the «risk alleles,» which are not causative of GDV but are highly associated.