Sentences with phrase «identified risk alleles»
Current collaborative efforts using germ line DNA to identify risk alleles are ongoing.112 An improved understanding of the interaction between inherited risk alleles and the environment (lifestyle choices) could provide a potential means of prevention.
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Individuals were classified as high risk for Alzheimer's if a DNA test identified the presence of a genetic marker — having one or both of the apolipoprotein E-epsilon 4 allele (APOE - e4 allele) on chromosome 19 — which increases the risk of developing the disease.
Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.
Performing genetic studies in multiple human populations can identify disease risk alleles that are common in one population but rare in others, with the potential to illuminate pathophysiology, health disparities, and the population genetic origins of disease alleles.
Such strategies may identify compensatory mutations that reduce the pathophysiological effects of the risk alleles, and help determine the cellular pathways required for the normal function of hSERT.
15 In fact, type 2 diabetes (T2D)-- a condition stemming from broken glucose metabolism and insulin signaling — has been identified as an additional risk factor for developing AD.16, 17 Moreover, the pathological changes that occur in AD in the brain physically resemble those seen in the pancreas and vasculature in T2D.9, 18 Type 2 diabetics who carry ApoE4 alleles are at the greatest risk for AD, with an even more severe risk reserved for those treated with exogenous insulin.19 This suggests that either T2D or related features of the metabolic syndrome bring about AD, or that they are separate consequences of the same underlying cause — and moreover, that insulin is a key factor.
The test identifies seven mutations in three different genes which permits identification of the «risk alleles,» which are not causative of GDV but are highly associated.
Researchers at the Fred Hutchinson Cancer Research Center have identified three risk alleles in three different genes associated with GDV in Great Danes.