Sentences with phrase «if tumor cells»

If tumor cells are not present in the sentinel node, the primary tumor most likely has not spread to lymph nodes or other organs.

If tumor cells are present within the node, the primary tumor has spread and additional lymph nodes may need to be removed and medical treatments tailored accordingly.

Aware that cancers rewire their metabolism in ways that could change the epigenome and that distant metastases in pancreatic cancer naturally spread to organs fed by a sugar - rich blood supply, the researchers wondered if the tumor cells had altered the way they use the basic form of sugar, glucose.

Not exact matches

So even if a tumor is surgically removed, it is difficult to extract every cancerous cell; any left behind will result in the growth of a new tumor.

«For pro-life folk, imagine a country where it was illegal to remove a tumor, even if the tumor might kill the host, because the tumor is its own collection of living cells.

But that gives scientists a secret weapon — if they can harness stem cells» natural ability to «home» toward tumor cells, the stem cells could be manipulated to deliver cancer - killing drugs precisely where they are needed.

If we are able to keep the tumor cells contained and let them fight it out, we would expect to see more competitively fit cells that are growing very slowly.»

If the tumor that Jobs had removed in 2004 had begun to break down prior to the surgery, White says, the tumor's dead cells could have released protease and lipase enzymes that may have damaged beta cells in the pancreas, which produce insulin.

Along with the study's co-first authors, Drs. Aayoung Hong and Gatien Moriceau, Lo hypothesized that if they could identify the key tumor cell processes triggered by withdrawal of MAPK inhibitors, then scientists can exploit these process with existing or investigational drugs to trigger the maximal levels of tumor cell death immediately following cessation of the initial therapy.

If we can boost the immune system and allow microglia to do their job and control brain tumor stem cells, it would be like removing the seed from the soil — stopping the tumor growth before it starts to get out of control.»

You have T cells for the rest of your life, so if the tumor reoccurs those T cells can mobilize themselves again against the tumor.

«If we can identify the point at which tumor cells acquire the characteristics of stem cells, it will be possible to look for ways to interrupt the process and avoid progression of the disease.»

«We know that if you take these tumor cells out of a patient and put them in a petri dish, they can be killed by chemotherapy,» Beatty said.

According to Dr. Cripe, the study suggests that some patients could respond to therapy even if their tumors aren't very infectable by the virus, provided their immune systems were stimulated by the viral therapy to attack the tumor cells.

The arithmetic is complex, but the consensus is that, to pose a health threat, cancers have to replicate at least 200 to 300 times, even though a clinically relevant tumor contains «only» a million million cells, which could be achieved by «only» 40 or so divisions if the originating cell had all the necessary mutations from the outset.

If they can be used in living tissue, they might eventually track cells in developing embryos, the immune system, or cancerous tumors.

If a given drug cocktail kills 90 percent of the cancer cells but doesn't affect the remaining 10 percent, the resistant tumor cells can take over and cause the tumor to grow back.

They found that if autophagy — the intracellular recycling process — is blocked in tumor cells, they produce cytokines that attract NK cells.

If metastatic cancers are most often made up of cells with different genetic drivers, perhaps researchers should be targeting the primary tumor with multiple drugs to contain the cancer.

The modified T cells are then reinfused back into a patient and, if all goes well, attack the person's NY - ESO - 1 — displaying tumors.

If the stem cells lose Numb, however, p53 levels plunge and the cells proliferate uncontrollably, leading to the emergence of cancer stem cells that drive the growth of breast tumors.

In human cells as well, if Nbs1 and ATM function in the same way to ensure repair of DNA damage, tumor formation may be prevented.

To see if PGD and the pentose phosphate pathway were tied to the epigenetic changes the researchers had detected in distant metastases, they treated tumor cells from different sites in a single patient with the drug 6 - aminonicotinamide (6AN), which is known to inhibit PGD but is not used in humans because of its severe side effects.

«We have shown that our molecule works on cancer cells in the lab, but the next step is to see if it works on real tumors in animals.

If the signaling error occurs before the cells have differentiated to become either bone or hair or skin, the result can be a teratoma, a tumor that contains a jumble of cell types.

«The cells that escape detection are the ones that, if not removed, are the most likely to result in treatment failing and a tumor recurring.

In experiments involving mice injected with human GBM cells, the scientists also demonstrated that if either PTEN or DAXX were eliminated, then tumor growth occurred.

The light - sensitive cells and nanoparticles, called opto - CRAC, were then delivered with the tumor antigen surrogate ovalbumin to mice with melanoma tumors in their lymph nodes to see if an immune response could be activated to target cancer cells.

If the targeted RNA encodes a tumor suppressor protein, as scientists have found for some, the ultimate effect of the microRNA could be to promote cell — and tumor — growth.

Encouraged by these results, the scientists wondered if Listeria could be used to deliver cancer - fighting therapies straight to tumor cells, including metastatic ones.

They work particularly well if the cancer cells they attack already have defects in the corresponding DNA repair pathways, as it frequently occurs in breast cancer and other tumors.

In the new study, the researchers cultured mouse skin - cancer colonies on various 2 - D and 3 - D environments of different shapes and patterns to see if the tumor shape contributes to activation of cancer stem cells, and to see where in the tumor the stem cells appeared.

«If the CD117 cell population does lead to tumor initiation or cancer reoccurrence, this cell marker could become a therapeutic target,» she says.

Researchers believe that if the body contains enough of the protein, the immune system will recognize it as a potential danger and send out armies of disease - killing cells to seek and destroy tumors harboring it.

And if fetal cells protect women from breast cancer, they might also safeguard against other tumors.

This is essential if one wants to claim that the cells, and thereby the research results, are true representatives of the original tumor.

«These slow - growing cells are apparently kept in check by the rest of the tumor, somehow — indeed, if you remove them from a tumor, they grow like crazy.»

«In extreme cases, if the dose is too high radiation can modify the cellular structure and generate alteration in the cells of organs found near the tumor, this causes them to lose their functions,» said Massillon, who was honored for her research with the IUPAP Young Scientist Prize 2015 awarded by the International Union of Pure and Applied Physics.

If a cell fails to produce the ultraconservated RNA, microRNA gets altered and hundreds of genes that should maintain cellular balance does and thus contributes to the formation of human tumors,» concludes Manel Esteller.

Numerous studies have already shown that cancer spreads particularly aggressively if there is an unfavorable balance between suppressing and active immune cells in the tumor microenvironment.

Overall, including all genomic variations present in most if not all tumor cells (clonal) as well as those present only in subsets of the cancer cells (subclonal) from tumor tissue, the researchers detected a total of 864 genetic changes in tissue samples across the three tumor types, and 627 (73 %) of those were also found in the blood.

If it is, we know that the Y - 90 DOTATOC radiotherapy will also reach the tumor and be able to kill tumor cells.»

The identification of patients with high - risk breast cancer is key to knowing whether a patient will require only the removal of the tumor by surgery or whether if she will need additional chemotherapy to make sure the removal of breast cancer cells.

The problem, said Lin, is that if a tumor has been growing for years there are no longer any T - cells inside it to activate, so the therapy fails.

«If we can confirm that substantial signal levels originate from glucose in the cell interior, this would be important additional information for tumor imaging and functional MRI.

What's more, the drug also increased the immune system's «memory» cells so that they could attack the tumor if it ever reared its head again.

If you're hoping the loudmouth on the cell phone next to you will get a brain tumor, you're likely to be disappointed.

We decided to look at the exosomes of stromal cells, a type of cell that is commonly found in the tumor microenvironment, and see if stromal exosomes were influencing the energy consumption of cancer cells.»

«If you were to compromise the altered physiology of tumors with something like RHT, the cancer cells are going to be less able to tolerate other therapeutic insults, and that probably would give you more effective therapies.

Next they treated the experimental tumor cells with MIR506 to determine if it would behave in the same way it had with ovarian and other cancers.