Among the 119 B cell neoplasias, microscopic BM involvement was positive in 31 cases and
Ig gene rearrangement was detected in 25 of 31.
In 5 % (6/119) of B cell neoplasias, the BM involvements were detected by microscopic evaluation, but
Ig gene rearrangements were negative.
Not exact matches
Kin Ritchie, Ralph Brinster, and Ursula Storb show that an IgL transgene inhibits
rearrangement of endogenous IgL
genes, providing the first clue for the mechanism of allelic exclusion of
Ig genes.
MRD was assessed using polymerase chain reaction analysis of
Ig / TCR
gene rearrangements.
In 6 cases,
Ig / TCR
gene rearrangement test did not detect BM involvement, which was presented by microscopy.