Sentences with phrase «ig genes»

Shen H, Peters A, Baron B, Zhu X, Storb U. Mutation of BCL - 6 gene in normal B cells by the process of somatic hypermutation of Ig genes.

Kin Ritchie, Ralph Brinster, and Ursula Storb show that an IgL transgene inhibits rearrangement of endogenous IgL genes, providing the first clue for the mechanism of allelic exclusion of Ig genes.

Andy Peters and Ursula Storb show that the initiation of Ig gene transcription targets Ig gene somatic hypermutation (SHM), by duplicating the variable (V) region promoter upstream of the constant (C) region and showing that a second wave of mutations occurs over the C region.

In 5 % (6/119) of B cell neoplasias, the BM involvements were detected by microscopic evaluation, but Ig gene rearrangements were negative.

Among the 119 B cell neoplasias, microscopic BM involvement was positive in 31 cases and Ig gene rearrangement was detected in 25 of 31.

Not exact matches

Since genes for the T - cell receptor beta chain were previously shown to be on mouse chromosome 6, all three of the Ig - like multigene families expressed and rearranged in T cells are located on different chromosomes, just as are the B - cell multigene families for the Ig heavy chain, and the Ig kappa and lambda light chains.

Building on work by Johnson's group, Farzan's team stitched the gene for eCD4 - Ig into an adeno - associated virus (AAV) that is harmless to humans.

MRD was assessed using polymerase chain reaction analysis of Ig / TCR gene rearrangements.

In 6 cases, Ig / TCR gene rearrangement test did not detect BM involvement, which was presented by microscopy.

The NP - reactive B cells from splenic germinal centers (GC) were recovered by microdissection of frozen tissue sections and their rearranged Ig heavy chain variable region (VH) genes of the V186.2 / V3 families were sequenced.

Recent studies in mice suggested that antibodies produced by old individuals may be encoded by distinct immunoglobulin (Ig) genes and that the somatic hypermutation process in these individuals is compromised.

Developing B cells use somatic hypermutation (SHM) to diversify their immunoglobulin (Ig) genes.

Developing B cells activate and diversify their immunoglobulin (Ig) genes by recombination, gene conversion (GC) and somatic hypermutation (SHM).

This activity can be directed to any gene of interest that can be inserted into the Ig locus [11].

A DT40 mutant lacking its pseudo-Ig genes has a naturally strong hypermutation activity at the Ig light chain locus [10].

They do believe IGs have a form of PRA that is inherited as a simple recessive (autosomal recessive) and they are continuing the hunt for the gene that causes this as yet unidentifed form of PRA.

However, like most purebred dogs, IGs have a relatively limited gene pool, and excessive culling can reduce genetic diversity.