The NP - reactive B cells from splenic germinal centers (GC) were recovered by microdissection of frozen tissue sections and their rearranged
Ig heavy chain variable region (VH) genes of the V186.2 / V3 families were sequenced.
Since genes for the T - cell receptor beta chain were previously shown to be on mouse chromosome 6, all three of the Ig - like multigene families expressed and rearranged in T cells are located on different chromosomes, just as are the B - cell multigene families for
the Ig heavy chain, and the Ig kappa and lambda light chains.
Not exact matches
A viral epitope inserted into the complementarity - determining region 3 (CDR3) loop of the
heavy chain of a self immunoglobulin (
Ig) molecule was generated from the
Ig context and was presented by I - Ed class II molecules to virus - specific, CD4 + T cells.
Independent trafficking of
Ig - α /
Ig - β and μ -
heavy chain is facilitated by dissociation of the B cell antigen receptor complex.