Sentences with phrase «in a larger study involving»

In a larger study involving 162 patients, tumors shrank in 20 percent of the patients.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Academic studies have found that a significant proportion of hedge fund interventions involve large increases in leverage and large decreases in investment, particularly in research and development.

Both studies came to the same basic conclusion: that the risks and uncertainties involved in budget forecasting were simply too large to allow for a high level of forecast accuracy.

This was the largest study of angel investment returns ever conducted, analyzing results from 86 organized angel investor groups throughout the United States, involving 539 individual angel group investors who have experienced more than 1,130 exits in which investment - receiving companies were acquired, went public, or were closed.

Throughout our website, we strive to provide you with health benefit information that is based on human studies involving large numbers of people who consume foods in an everyday way.

I would suggest you read http://www.ahrq.gov/Clinic/tp/brfouttp.htm"rel = «nofollow» > Breastfeeding and Maternal and Infant Health Outcomes in Developed Countries, which is a metaanalysis of a large number of studies involving breastfeeding and formula feeding in developed countries.

• A study that followed a large group of U.S. children over 10 years, found that although mothers» depression was related to escalating child behavior problems, this was not the case among children who said their fathers were highly involved in their lives (Chang et al, 2007).

He points to research by a Stanford University researcher, Allan K. Mishra, who has studied PRP for years, whose in his most recent published research includes a large multicenter study [8] involving a host of well - respected orthopedic surgeons around the country who followed 230 patients in a double - blind randomized control study [the gold standard for medical research].

* And in the largest and possible most systematic study to date, conducted on five different ethnic groups from both Chicago and New York involving over 1,400 subjects Mosenkis (2000) found far more positive adult outcomes for individuals who coslept as a child, among almost all ethnic groups i.e. African Americans and Puerto Ricans in New York, Puerto Ricans, Dominicans, and Mexicans in Chicago than there were negative findings.

Félix is also involved in a larger project studying migrants» remittances in a historical perspective.

A study of why Wang succeeded where others failed, concluded that efforts to involve the media and other experts, and the framing of the issue as symbolic of a larger, rather than individual, problem were crucial in building widespread support for the case.2

From the Department of Environmental Protection, documents and records being sought include studies showing whether New York City is aware that large construction projects that involve the replacement of lead service lines could lead to spikes in the presence of lead in tap water.

«Being able to walk around in something that is going to grow larger as you grow larger, that's a big plus,» says Jan Pechenik, a biologist at Tufts University in Medford, Mass., who was not involved in the study.

The research involved 93 members of the Wisconsin Registry for Alzheimer's Prevention (WRAP), which with more than 1,500 registrants is the largest parental history Alzheimer's risk study group in the world.

The American, Korean and Australian partners involved with the GMT will take advantage of the telescope's Southern Hemisphere location to study the otherwise hidden Large and Small Magellanic Clouds — two of the Milky Way's nearest neighbor galaxies — and the black hole in the center of our galaxy.

You are now involved in your largest effort yet, the National Children's Study.

Scientists have shifted from studying single molecules to investigating large complexes of interacting biological macromolecules involved in processes such as metabolic pathways, gene expression, and development of disease.

The results of this article, part of the European study HELENA involving nine countries, demonstrated that eating larger amounts of egg is neither linked to higher serum cholesterol nor to worse cardiovascular health in adolescents, regardless of their levels of physical activity.

Studies involving rabbits and larger mammals, for example, are overseen chiefly by the U.S. Department of Agriculture (USDA) in Washington, D.C. Federally funded studies of rats, mice, and birds are subject to different rules and a different overseer, the National Institutes of Health (NIH) in Bethesda, MaStudies involving rabbits and larger mammals, for example, are overseen chiefly by the U.S. Department of Agriculture (USDA) in Washington, D.C. Federally funded studies of rats, mice, and birds are subject to different rules and a different overseer, the National Institutes of Health (NIH) in Bethesda, Mastudies of rats, mice, and birds are subject to different rules and a different overseer, the National Institutes of Health (NIH) in Bethesda, Maryland.

And scientists who conduct human challenge studies, which typically involve a few dozen participants, say they have critical benefits: In addition to saving time and money, they can reveal harm caused by a potential drug or vaccine before it enters large - scale human efficacy trials.

For that reason, says Travis Longcore, an urban ecologist at the University of Southern California Dornsife who was not involved in the study, the new atlas only provides a minimal baseline for what are likely much larger levels of light pollution.

Women using depot medroxyprogesterone acetate (DMPA), commonly known as Depo - Provera or the birth control shot, have a moderately increased risk of becoming infected with HIV, a large meta - analysis of 12 studies involving more than 39 500 women published in The Lancet Infectious Diseases has found.

The researchers found five different sub-types of HL among the patients studied: 247 cases of the nodular sclerosis (NS) type, in which the tumour nodules are large; 105 of mixed cellularity, where a mixture of different types of inflammatory cells are involved; 58 lymphocyte rich, the sub-type with the best outcome; 68 «others»; and 143 «not otherwise specified» (NOS).

The paper is a technical analysis of the uncertainties involved in computer modeling studies that use the amount of phosphorus entering Lake Erie in the spring to predict the size of late - summer cyanobacteria blooms, which have grown larger since the mid-1990s.

Gathering this detailed information required a remarkable collaboration involving five of the largest studies of HIV risk carried out in Africa.

«Verification of Rotation in Tornadoes EXperiment2 is the largest and most ambitious attempt to study tornadoes in history and will involve more than 50 scientists and 40 research vehicles, including 10 mobile radars,» says the National Oceanic and Atmospheric Administration, a sponsor along with the National Science Foundation and some nonprofit groups.

The study suggests there may be «many more such instances of misidentification of animal species» — especially considering that the sunfish is relatively large and hard to miss — says Byrappa Venkatesh, a geneticist at the Institute of Molecular and Cell Biology in Singapore, who was not involved in the new research.

«There is no convincing evidence that a sufficiently large reservoir of old metabolic carbon existed in some mysterious location in the glacial ocean only to be ventilated during deglaciation,» argues paleoclimatologist Lowell Stott of the University of Southern California, who was not involved in the study.

The study involved 375 undergraduate students at a large, public university in the southeastern U.S..

«These are the best - done and largest assessments of how the microbiome may influence therapeutic outcome» from those drugs, says immunotherapy researcher Jeffrey Weber of New York University in New York City, who was not involved in the studies.

The study, published in The BMJ, is the largest research project in the world looking at lifestyle interventions in pregnancy, involving more than 50 researchers from 41 institutions.

Up until now, large health studies have been expensive and time consuming, involving manual surveys in unrealistic laboratory settings.

The large, population - based study also found a correlation between preeclampsia and developmental delay without autism, primarily in instances involving placental insufficiency.

The protein studied in the mold is part of a larger family of proteins also found in humans and involved in many essential biological processes including gene regulation and fatty acid metabolism.

The orbits of exocomets on Beta Pictoris could also help scientists trace the presence and migration of larger, undetected bodies such as gas giant planets in the planetary system, says Russel White, an astronomer at Georgia State University in Atlanta who was not involved in the study.

The benefits of treating serious strokes with clot removal were shown in 2015, when five separate studies analyzing a total of 1,287 patients showed that severe stroke patients — usually with clots involving the largest blood vessels in the brain — who received both the clot - snatching procedure and the medicine did significantly better than those who got medicine alone.

Even with such corrections, Fang said, «Our study suggests that research misconduct does not involve a large percentage of research funding in the United States.»

Many of the variants involved in numerous types of cancer have been identified with genetic sequencing studies of large numbers of patients.

As a result, «they were able to more finely divide up the day in terms of the different types of activity the animals were engaged in,» says John Laundré, a large carnivore ecologist at UC Riverside, who was not involved in either study.

Seismologist Austin Holland of the Oklahoma Geological Survey, who was not involved in the study, says there could be a large number of factors playing into the quakes.

The study, performed by researchers in Europe and involving detailed computer simulations, shows that large - scale metamaterials can attenuate the energy and amplitude of harmful low - frequency vibrations associated with seismic shocks.

In the near - term, the next step is to confirm the new findings in a larger study, involving about 300 study patientIn the near - term, the next step is to confirm the new findings in a larger study, involving about 300 study patientin a larger study, involving about 300 study patients.

«It is revolutionary for the problem of mosaicking large volumes of imagery,» says computer scientist Dalton Rosario of the U.S. Army Research Laboratory in Adelphi, Maryland, who was not involved with the study.

Malin Pinsky, an ecologist at Rutgers University who studies population dynamics of coastal marine species and who was not involved in the research, described the study as significant because of its unusually large scope, as well as its focus on different fish life stages.

The system is being studied for use in the pig breeding industry to determine the quality of boar semen and can also be used to screen large numbers of men for fertility in industrial situations which involve possible chemical or radiation hazards.

«This paper will cause a stir as it really is the first to scientifically illustrate the value of fencing for the conservation of a large predator,» predicts Matt Hayward, a wildlife ecologist with the Australian Wildlife Conservancy in New South Wales, who was not involved in the study.

«We observed that a large number of genes were involved in pathways related to wound healing, immunity, and metabolism, and this is consistent with the idea that the earliest stages of domestication may involve adapting to highly crowded conditions,» said Mark Christie, lead author of the study.

The first task, says Farrow, will be to verify the 2007 photosynthesis results; after this, the team will study the larger and more complex molecules involved in mitochondrial energy transfer.

Michael Hansen, a biologist at Aarhus University in Denmark who was not involved in the study, agrees the age of the eels is the largest potential source of error, but says the results make sense biologically, which convinces him it was not a major issue.