Sentences with phrase «in a normal mouse model»

Not exact matches

«The successful restoration of normal function demonstrated in the mouse models suggests that if we can develop therapies to address the loss of Mecp2,» Baylor's Zoghbi says, «we may be able to reverse neurological damage in children and adults with Rett, autism and related neuropsychiatric disorders.»

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

In their research, authors Sajedah M. Hindi, Ph.D., and Ashok Kumar, Ph.D., discovered that removing TRAF6 depletes Pax7, resulting in reduced muscle regeneration in both normal and Duchenne muscular dystrophy (DMD) mouse modelIn their research, authors Sajedah M. Hindi, Ph.D., and Ashok Kumar, Ph.D., discovered that removing TRAF6 depletes Pax7, resulting in reduced muscle regeneration in both normal and Duchenne muscular dystrophy (DMD) mouse modelin reduced muscle regeneration in both normal and Duchenne muscular dystrophy (DMD) mouse modelin both normal and Duchenne muscular dystrophy (DMD) mouse models.

«Transplanted hematopoietic stem cells reverse damage caused by neuro - muscular disorder: In mouse model of Friedreich's ataxia, a single infusion measurably restored normal cellular functions.»

In this study, tungstate treatment in mouse models of colitis shifted gut microbiota to a more normal state in terms of the balance of bacterial species and also reduced gut inflammation, the researchers reporIn this study, tungstate treatment in mouse models of colitis shifted gut microbiota to a more normal state in terms of the balance of bacterial species and also reduced gut inflammation, the researchers reporin mouse models of colitis shifted gut microbiota to a more normal state in terms of the balance of bacterial species and also reduced gut inflammation, the researchers reporin terms of the balance of bacterial species and also reduced gut inflammation, the researchers report.

Lastly, they plan to vary the timing of exposure to the various diets in the mouse model of autism, by, for example, giving pregnant mice a high - glycemic index diet and then keeping their pups on a normal diet.

Now, thanks to the new mouse model, it will be possible to study how renal tumors are able to develop in an environment with a normal immune system, and how cancer cells manage to evade the immune system's attacks.

Dr. Baran Sumer (left) and Dr. Jinming Gao (right) and have invented a transistor - like threshold sensor that can illuminate cancer tissue, helping surgeons more accurately distinguish cancerous from normal tissue in mouse models.

In normal mice, stem cells (pink) express dystrophin (green) and are able to easily generate new muscle fibers, but in the disease model, there is no dystrophin and the stem cells lose their sense of direction and have trouble generating new muscle fiberIn normal mice, stem cells (pink) express dystrophin (green) and are able to easily generate new muscle fibers, but in the disease model, there is no dystrophin and the stem cells lose their sense of direction and have trouble generating new muscle fiberin the disease model, there is no dystrophin and the stem cells lose their sense of direction and have trouble generating new muscle fibers.

The normal mice and the AS model mice with diminished expression of the Na / K - ATPase subunit searched the correct area of the maze in the same amount of time.

They examined behaviors of the following types of mice: normal mice, AS model mice, mice that had reduced levels of the Na / K - ATPase, and AS model mice in which expression of the subunit of Na / K - ATPase was reduced.

Finally, we generate new tools and mouse models to study the role of de novo protein synthesis in normal brain function and in pathophysiology associated with neurodevelopmental and neurodegenerative disease.

The hTNFR1KI mice have normal phenotype and can be used in combination to other genetic models (e.g. Tg197hTNFR1KI) or with a variety of induced disease models in order to test the efficacy of anti-human TNFR1 therapeutics.

Winkler, E. A., Bell, R. D. & Zlokovic, B. V. Pericyte - specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling.

Another behavior that scientists have observed in Huntington's disease model mice is that they aren't as motivated as normal mice to drink sweet water.

J147 increases the levels of BDNF in the hippocampus of normal rats, as well as in huAPP / PS1 transgenic mice [7], and its synthetic precursor, CNB - 001, increases BDNF levels in rat traumatic brain injury models [54].

A 50 % reduction in HDAC4 restored these and other electrophysiological changes in both the R6 / 2 model, a transgenic over-expresser of Exon 1 HTT with an expanded polyglutamine repeat, and heterozygous Q175 knock - in mice (Q175 + / --RRB-, which carry one normal and one mutant HTT allele with an expanded repeat of ~ 190 polyglutamines, in addition to reversing behavioral alterations in R6 / 2 mice (Mielcarek et al, 2013; PLOS Biology, in press).

In order to better understand the liabilities associated with reducing normal htt in adult mice, we evaluated the effects of a robust knock down of WT htt both in CNS and periphery in a conditional htt knock - down (KD) model induced by doxycyclinIn order to better understand the liabilities associated with reducing normal htt in adult mice, we evaluated the effects of a robust knock down of WT htt both in CNS and periphery in a conditional htt knock - down (KD) model induced by doxycyclinin adult mice, we evaluated the effects of a robust knock down of WT htt both in CNS and periphery in a conditional htt knock - down (KD) model induced by doxycyclinin CNS and periphery in a conditional htt knock - down (KD) model induced by doxycyclinin a conditional htt knock - down (KD) model induced by doxycycline.

In research funded by the Wellcome Trust, Professor Zernicka - Goetz and colleagues developed a mouse model of aneuploidy by mixing 8 - cell stage mouse embryos in which the cells were normal with embryos in which the cells were abnormaIn research funded by the Wellcome Trust, Professor Zernicka - Goetz and colleagues developed a mouse model of aneuploidy by mixing 8 - cell stage mouse embryos in which the cells were normal with embryos in which the cells were abnormain which the cells were normal with embryos in which the cells were abnormain which the cells were abnormal.

It should be noted, however, that while a study on senescent cell ablation in genetically normal mice would provide at least some evidence on the effect of senescent cells (and their ablation) on promoting cancer, even such a study would likely show less effect than could be anticipated in a large mammal model, since even normally - aging mice rarely suffer metastatic disease to the extent of aging humans, as sheer primary tumor volume is generally sufficient to be fatal to mice.

The researchers looked at the dentate gyrus, a specific area of the brain that is critical to memory and particularly vulnerable in Alzheimer's disease, and compared the genes that were turned on and off in normal mice and a mouse model of Alzheimer's disease.

«This mouse strain is great model for this research because they are otherwise healthy and normal, including in their vision, so it allows us to conduct studies focused on cell integration,» said the publication's lead author, Jie Zhu, PhD, a postdoctoral researcher who started in Lamba's lab three years ago.

◊ mouse models for diseases: phenotyping approaches: courses in English, March 14 - 17 in Illkirch - Strasbourg (CFE, PHENOMIN - ICS) ◊ European Advanced School for Mouse Phenogenomics: in English, June 12 - 16 at Liebfrauenberg in Alsace (PHENOMIN) ◊ necropsy, sampling and histology: June 19 - 23 in Toulouse (ENVT, Anexplo) ◊ normal and abnormal embryology of laboratory animals: March 13 - 17 + May 29 to June 3 + Décember 4 - 8 in Toulouse (ENVT, Anemouse models for diseases: phenotyping approaches: courses in English, March 14 - 17 in Illkirch - Strasbourg (CFE, PHENOMIN - ICS) ◊ European Advanced School for Mouse Phenogenomics: in English, June 12 - 16 at Liebfrauenberg in Alsace (PHENOMIN) ◊ necropsy, sampling and histology: June 19 - 23 in Toulouse (ENVT, Anexplo) ◊ normal and abnormal embryology of laboratory animals: March 13 - 17 + May 29 to June 3 + Décember 4 - 8 in Toulouse (ENVT, AneMouse Phenogenomics: in English, June 12 - 16 at Liebfrauenberg in Alsace (PHENOMIN) ◊ necropsy, sampling and histology: June 19 - 23 in Toulouse (ENVT, Anexplo) ◊ normal and abnormal embryology of laboratory animals: March 13 - 17 + May 29 to June 3 + Décember 4 - 8 in Toulouse (ENVT, Anexplo)

Spermidine Ameliorates Neurodegeneration in a Mouse Model of Normal Tension Glaucoma.