Sentences with phrase «in early clinical»

«We are very excited about using VSV as researchers have seen promising results using other similar viruses, such as the polio virus, in early clinical trials.»

With multiple therapeutic approaches now either in early clinical trials or nearing human testing, optimism is starting to mount that one of these approaches will ultimately prove a success.

«For those of us who saw the AIDS epidemic explode and who watched helplessly as thousands died, the opportunity to try to develop an HIV cure is truly amazing,» said Paul Volberding, MD, a UCSF professor of medicine who started the Positive Health Program at Zuckerberg San Francisco General Hospital and Trauma Center in the early days of the epidemic and was a leader in early clinical trials to evaluate antiretroviral therapy.

One specific form of this approach, called chimeric antigen receptor (CAR) T cell therapy, has been shown in early clinical trials to be particularly effective at treating lymphoma.

Several approaches to immunotherapy for esophageal cancer have shown promise in early clinical trials.

Several approaches to immunotherapy for pancreatic cancer have shown promise in early clinical trials.

Both recent experience with immunotherapy for clearance of Aβ in AD, and their own (and Prothena's) experience with AS - clearing immunotherapies in animal models, indicate that in order to be effective as disease - modifying agents when administered alone, therapies that remove proteinaceous aggregates from the brain must be initiated in the early clinical or even preclinical stages of the disease, before the burden of other forms of aging damage becomes entrenched.

Adult mice don't need the gene that, when mutated in humans, causes the inherited neurodegenerative disorder Huntington's disease. The finding suggests that treatment strategies for Huntington's that aim to shut off the huntingtin gene in adults — now in early clinical stages — could be safe.

In early clinical trials of these drugs, we noticed that in some breast cancer patients the tumors didn't just remain the same size — as would be expected with drugs that interfere with cell division — but began to recede, sometimes quite dramatically, said Goel.»

In early clinical trials, Sessler and his colleagues treated 39 metastatic brain tumor patients with texaphyrins 2 hours before radiation therapy for 10 days.

The finding suggests that treatment strategies for Huntington's that aim to shut off the huntingtin gene in adults — now in early clinical stages — could be safe.

Fiers discovered a key protein on the influenza virus that could serve as a target for a universal vaccine; the drug has shown promise in an early clinical trial.

But often, people in the earlier clinical trials did not take their pills or insert the vaginal gels.

Not exact matches

Following a devastating clinical trial setback earlier this month for its lead experimental product, a cannabidiol gel, in epilepsy, the firm reported another trial failure on Monday for the product in treating knee pain due to osteoarthritis.

In an editorial about Theranos in the journal Clinical Chemistry and Laboratory Medicine earlier this year, Eleftherios P. Diamandis, the head of clinical biochemistry at Mount Sinai Hospital in Toronto, argued that fingerprick tests are not necessarily any more painful than needle draws — though there still might be an appeal for someone afraid of needleIn an editorial about Theranos in the journal Clinical Chemistry and Laboratory Medicine earlier this year, Eleftherios P. Diamandis, the head of clinical biochemistry at Mount Sinai Hospital in Toronto, argued that fingerprick tests are not necessarily any more painful than needle draws — though there still might be an appeal for someone afraid of needlein the journal Clinical Chemistry and Laboratory Medicine earlier this year, Eleftherios P. Diamandis, the head of clinical biochemistry at Mount Sinai Hospital in Toronto, argued that fingerprick tests are not necessarily any more painful than needle draws — though there still might be an appeal for someone afraid of Clinical Chemistry and Laboratory Medicine earlier this year, Eleftherios P. Diamandis, the head of clinical biochemistry at Mount Sinai Hospital in Toronto, argued that fingerprick tests are not necessarily any more painful than needle draws — though there still might be an appeal for someone afraid of clinical biochemistry at Mount Sinai Hospital in Toronto, argued that fingerprick tests are not necessarily any more painful than needle draws — though there still might be an appeal for someone afraid of needlein Toronto, argued that fingerprick tests are not necessarily any more painful than needle draws — though there still might be an appeal for someone afraid of needles.

Shares of pioneering CRISPR gene - editing firm Editas fell 7 % in early Tuesday trading after the company announced that it would delay an initial FDA filing for clinical trials of one of its lead drugs, LCA10, to the middle of next year (Editas had originally planned to file by the end of 2017).

Shares of cancer - focused biotech Clovis Oncology soared nearly 50 % in early Monday trading on the strength of clinical trial results for its ovarian cancer treatment Rubraca.

Many people believe that eating early in the morning will jumpstart your metabolism or that eating late at night will widen your waist because it's already asleep, but this study from the American Journal of Clinical Nutrition concluded that's a false claim.

In the early 1990s, Pfizer began clinical trials in Britain for the drug, which by then it had named ViagrIn the early 1990s, Pfizer began clinical trials in Britain for the drug, which by then it had named Viagrin Britain for the drug, which by then it had named Viagra.

The programs are still in early days, with the Parkinson's program aiming to start its clinical trials in 2018.

Early phase clinical trials in Australia are 28 % cheaper than the USA before tax incentives, and 60 % cheaper after tax incentives.

Early clinical trials indicate that restricting calorie intake seems to trigger similarly promising physical changes in people, which is why it's sometimes discussed as a potential anti-aging intervention.

Both products are still in clinical trials; a rep for Chrono said the opioid - related patch won't come to market before the smoking - cessation product, which is expected to be available in early 2019.

MEDIAL EARLYSIGN SHOWS AI AND EHR DATA CAN BE USED FOR EARLY DETECTION: Researchers from Medial EarlySign, a provider of machine - learning solutions, found that the combination of machine learning technology and electronic health record (EHR) data can be more effective than current clinical tools in identifying the risk of kidney damage in diabetics.

Through talking to experts in the field over the past year, Gates said he had identified five areas of need: Understanding better how Alzheimer's unfolds, detecting and diagnosing it earlier, pursuing multiple approaches to trying to halt the disease, making it easier for people to take part in clinical trials of potential new medicines, and using data better.

Grail, a year - old, Menlo Park, Ca. - based early cancer screening startup that spun out of the DNA - sequencing giant Illumina is reportedly looking to raise up to $ 1.7 billion in fresh funding to launch a large - scale clinical trial.

BioNTech hit the headlines in July when its experimental personalized cancer vaccine, tailored to the tumors of individual patients, kept disease in check in an early - stage clinical trial.

Earlier in his career, he started two companies, an early web catalog provider and a clinical trial software company.

To achieve this goal, several approaches are envisaged: identifying small populations with severe disease where a medicine's benefit - risk balance could be favorable; making more use of real - world data where appropriate to support clinical trial data; and involving health technology assessment bodies early in development to increase the chance that medicines will be recommended for payment and ultimately covered by national healthcare systems.

Katherine High, Spark's president and chief scientific officer, expressed her enthusiasm for the early clinical data related to SPK - 8011: «The encouraging start of our SPK - 8011 clinical trial reinforces the strength of our gene therapy platform, delivers human proof - of - concept in a second liver - mediated disease — a significant achievement in the gene therapy field — and positions us well to potentially transform the current treatment approach for this life - altering disease with a one - time intervention.»

In early September, Alnylam stopped giving doses of its fitusiran drug for a rare bleeding disorder to patients enrolled in clinical studies after the death of a patienIn early September, Alnylam stopped giving doses of its fitusiran drug for a rare bleeding disorder to patients enrolled in clinical studies after the death of a patienin clinical studies after the death of a patient.

Sad news from the halls of research today, in which a study published in the American Journal of Clinical Nutrition says that eating fried potatoes two or more times a week can double your risk of early death.

In the early days of chaplaincy service and clinical pastoral education, something very like this turned out for a while to be the main temptation.

It is curious that the early days of clinical pastoral education, which has done more than any other movement to foster the present knowledge and skill in pastoral care, actually relied only in part upon interviewing methods and yet made the interview image dominant as the ideal.

«Recent research on humans published in the American Journal of Clinical Nutrition earlier this year indicates that drinking diet beverages does not cause people to overeat or to increase their intake of sweet foods and beverages.

Read on for technical insights and market information on key usage applications and opportunities for these dairy ingredients in three growing categories that are highly dependent on high - quality protein sources: sports nutrition, infant and early child nutrition and clinical nutrition.

Two earlier peer - reviewed studies published in the American Journal of Clinical Nutrition by researchers from the University of North Carolina in 2012 and 2013 randomly assigned non-dieting participants to drink either water or diet beverages.

This is an incredibly difficult question to answer for a variety of reasons, most importantly because over the years our once vaunted «beautiful» style of play has become a shadow of it's former self, only to be replaced by a less than stellar «plug and play» mentality where players play out of position and adjustments / substitutions are rarely forthcoming before the 75th minute... if you look at our current players, very few would make sense in the traditional Wengerian system... at present, we don't have the personnel to move the ball quickly from deep - lying position, efficient one touch midfielders that can make the necessary through balls or the disciplined and pacey forwards to stretch defences into wide positions, without the aid of the backs coming up into the final 3rd, so that we can attack the defensive lanes in the same clinical fashion we did years ago... on this current squad, we have only 1 central defender on staf, Mustafi, who seems to have any prowess in the offensive zone or who can even pass two zones through so that we can advance play quickly out of our own end (I have seen some inklings that suggest Holding might have some offensive qualities but too early to tell)... unfortunately Mustafi has a tendency to get himself in trouble when he gets overly aggressive on the ball... from our backs out wide, we've seen pace from the likes of Bellerin and Gibbs and the spirited albeit offensively stunted play of Monreal, but none of these players possess the skill - set required in the offensive zone for the new Wenger scheme which requires deft touches, timely runs to the baseline and consistent crossing, especially when Giroud was playing and his ratio of scored goals per clear chances was relatively low (better last year though)... obviously I like Bellerin's future prospects, as you can't teach pace, but I do worry that he regressed last season, which was obvious to Wenger because there was no way he would have used Ox as the right side wing - back so often knowing that Barcelona could come calling in the off - season, if he thought otherwise... as for our midfielders, not a single one, minus the more confident Xhaka I watched played for the Swiss national team a couple years ago, who truly makes sense under the traditional Wenger model... Ramsey holds onto the ball too long, gives the ball away cheaply far too often and abandons his defensive responsibilities on a regular basis (doesn't score enough recently to justify): that being said, I've always thought he does possess a little something special, unfortunately he thinks so too... Xhaka is a little too slow to ever boss the midfield and he tends to telegraph his one true strength, his long ball play: although I must admit he did get a bit better during some points in the latter part of last season... it always made me wonder why whenever he played with Coq Wenger always seemed to play Francis in a more advanced role on the pitch... as for Coq, he is way too reckless at the wrong times and has exhibited little offensive prowess yet finds himself in and around the box far too often... let's face it Wenger was ready to throw him in the trash heap when injuries forced him to use Francis and then he had the nerve to act like this was all part of a bigger Wenger constructed plan... he like Ramsey, Xhaka and Elneny don't offer the skills necessary to satisfy the quick transitory nature of our old offensive scheme or the stout defensive mindset needed to protect the defensive zone so that our offensive players can remain aggressive in the final third... on the front end, we have Ozil, a player of immense skill but stunted by his physical demeanor that tends to offend, the fact that he's been played out of position far too many times since arriving and that the players in front of him, minus Sanchez, make little to no sense considering what he has to offer (especially Giroud); just think about the quick counter-attack offence in Real or the space and protection he receives in the German National team's midfield, where teams couldn't afford to focus too heavily on one individual... this player was a passing «specialist» long before he arrived in North London, so only an arrogant or ignorant individual would try to reinvent the wheel and / or not surround such a talent with the necessary components... in regards to Ox, Walcott and Welbeck, although they all possess serious talents I see them in large part as headless chickens who are on the injury table too much, lack the necessary first - touch and / or lack the finishing flair to warrant their inclusion in a regular starting eleven; I would say that, of the 3, Ox showed the most upside once we went to a back 3, but even he became a bit too consumed by his pending contract talks before the season ended and that concerned me a bit... if I had to choose one of those 3 players to stay on it would be Ox due to his potential as a plausible alternative to Bellerin in that wing - back position should we continue to use that formation... in Sanchez, we get one of the most committed skill players we've seen on this squad for some years but that could all change soon, if it hasn't already of course... strangely enough, even he doesn't make sense given the constructs of the original Wenger offensive model because he holds onto the ball too long and he will give the ball up a little too often in the offensive zone... a fact that is largely forgotten due to his infectious energy and the fact that the numbers he has achieved seem to justify the means... finally, and in many ways most crucially, Giroud, there is nothing about this team or the offensive system that Wenger has traditionally employed that would even suggest such a player would make sense as a starter... too slow, too inefficient and way too easily dispossessed... once again, I think he has some special skills and, at times, has showed some world - class qualities but he's lack of mobility is an albatross around the necks of our offence... so when you ask who would be our best starting 11, I don't have a clue because of the 5 or 6 players that truly deserve a place in this side, 1 just arrived, 3 aren't under contract beyond 2018 and the other was just sold to Juve... man, this is theraputic because following this team is like an addiction to heroin without the benefits

We can be ruthless on the counter too but we really need to be more clinical in front of goal, no matter the style we impose on the day, even if its smash and grab, we need to put our chances away and kill teams off early

Lacazette has showed early signs of his pace to get in behind opposition defences, as well as his clinical finishing, as he scored both goals in Arsenal's most recent victory at the Emirates Stadium.

Toss in his 57 % shooting accuracy, 14 % chance conversion rate, and an early season goal to better see the youngster's clinical nature in the final third.

Liverpool's attacking play has been outstanding at times this season but during those early games they lacked the clinical touch in the final third to round it off.

Clinical finishing has been a problem for the Golden Eagles of late so hopefully they can get the trio of Madden, Darian Powell, and Kylie Sprecher involved early in the game.

On being clinical in front of goal «We said today we had to come out with energy and get that early goal because Huddersfield have had a great start to the season, they are an energetic team themselves and we did that perfectly.

«The identification of a potentially injurious impact or series of impacts via real - time monitoring of head impact exposure in athletes may [not only] facilitate the early recognition and management of brain injury in helmeted sports,» argues Richard M. Greenwald, PhD of the Thayer School of Engineering at Dartmouth College, lead author of an editorial in the March 2012 Clinical Journal of Sports Medicine, [6] but «permit early intervention, potentially in advance of an injury, rather than simply as a management tool postinjury.»

«The identification of a potentially injurious impact or series of impacts via real - time monitoring of head impact exposure in athletes may [not only] facilitate the early recognition and management of brain injury in helmeted sports,» argues Richard M. Greenwald, PhD of the Thayer School of Engineering at Dartmouth College, in an editorial in the March 2012 Clinical Journal of Sports Medicine, [12] but «permit early intervention, potentially in advance of an injury, rather than simply as a management tool postinjury.»

Clinical midwife manager for Wiltshire Community Health Services Amanda Gell said: «The pilot scheme responds to the needs of women who give birth either at night or the early hours of the morning and want the support of their partners in the crucial period after labour.

In her latest book, The Developmental Science of Early Childhood: Clinical Applications of Infant Mental Health Concepts from Infancy Through Adolescence, she describes how larger forces in the family and in the child's biology can affect behavior and how to understand a child's deep storIn her latest book, The Developmental Science of Early Childhood: Clinical Applications of Infant Mental Health Concepts from Infancy Through Adolescence, she describes how larger forces in the family and in the child's biology can affect behavior and how to understand a child's deep storin the family and in the child's biology can affect behavior and how to understand a child's deep storin the child's biology can affect behavior and how to understand a child's deep story.

Early clinical predictors of remission of peanut allergy in children.

Founded in 1996, the Brazelton Touchpoints Center is rooted in and builds upon the work of T. Berry Brazelton, MD, internationally renowned pediatrician, whose scientific research and clinical observations of babies and young children, beginning in the 1950s and spanning six decades, radically reshaped the field of early child development and the practice of pediatrics.