Sentences with phrase «in normal mice with»

In normal mice with working photoreceptors (PR driven), stimulating the retina produces a variety of responses in retinal ganglion cells, the output of the eye.

This was easily discernible objectively in the normal mouse with the aid of the cage movement registration method.

Not exact matches

Read this post for a refresher, but the short of it is they wreck your gut with inflammation that is on the order of causing (in mice anyway) IBD if predisposed, and if with a normal immune system, say hello to chronic low - grade intestinal inflammation and metabolic syndrome.

The team found neonatal mice with the mutations had normal - appearing skin, and the dry itchy skin of dermatitis did not develop until the mice were a few months old, the equivalent of a young adult in human years.

Even in the first week after an election, the Whitehall agents of the 800 lb gorilla of executive power are hard at work on the tiny but irritating squeak of the parliamentary mouse rather than fixing the broken democracy in partnership with parliament, «back to normal working» is not the slogan that will restore the reputation and capability of our democracy.

In experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cellIn experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cellin the face of rising TNF - alpha signals than normal cells.

«The successful restoration of normal function demonstrated in the mouse models suggests that if we can develop therapies to address the loss of Mecp2,» Baylor's Zoghbi says, «we may be able to reverse neurological damage in children and adults with Rett, autism and related neuropsychiatric disorders.»

But later, Javier Bravo at University College Cork managed to change the behaviour of normal adult mice by feeding them with a probiotic bacterium called Lactobacillus rhamnosus, often found in yoghurts and dairy products.

For this study the researchers targeted very specific types of GABA receptors to improve social behaviors with clonazepam, but the team also found that by using a different drug, they could target other GABA receptors and actually reduce the ability to socially interact in normal mice — underscoring that future medications would need to target very specific receptors so as not to diminish the drug's impacts.

But unlike the normal mice, those with altered macrophages showed no signs of inflammation, such as changes in insulin production, high levels of immune chemicals, and macrophages in their belly fat.

They compared mice genetically engineered to have increased levels of SIRT6 with normal mice, engineering the mice in two different ways to control for genetic influences.

Aside from a food intake in laboratory mice that's about 40 percent fewer calories than normal, however, it's been found that another way to activate this pathway is with rapamycin, which appears to have a significant impact even when used late in life.

The researchers found that the tissue made normal connections with surrounding nerves and muscle tissues in the mice, and those connections allowed the tissue to function normally.

Clarke and colleagues compared normal mice, whose gastrointestinal tracts were teeming with bacteria, with mice bred in sterile environments, whose guts didn't contain any microbes.

The researchers discovered that in brain regions involved in regulating anxiety — the amygdala and prefrontal cortex — microbe - free mice had an overabundance of some types of microRNA and a shortage of others compared with normal mice.

Alzheimer's mice with normal BACE1 levels experienced a steady increase in plaques, clearly seen in samples of their brains.

In contrast, control mouse pups dosed with plain saline solution showed normal connections throughout their cortical tissue.

But mice dads that lacked this receptor in the epididymis had offspring with normal hormonal responses.

By examining the brains of these mice, the researchers observed a substantial decrease in inhibitory CA2 neurons, as compared to a control group of normal, healthy mice — a change remarkably similar to that previously observed in postmortem examinations of people with schizophrenia.

«The challenge is finding targets that exist on other types of cancer cells but not on normal cells,» says pediatric oncologist Stephan Grupp of the Children's Hospital of Philadelphia, who worked with Porter on testing the treatment in mice.

The researchers raised genetically modified mice with a Parkinson's - like disease either in normal, non-sterile cages or in a germ - free environment.

They destroyed the T cells in 12 mice, five of which received marrow cells from normal mice while seven received marrow from mice with a defective Fas - ligand gene.

Mineral deposits and bone formation around toe joints of mouse with mutation in the ank gene (mutant foot shown on right, normal skeleton on left).

He and colleagues at the University of California, San Francisco, injected the brains of mice with prions they had created in the lab by misfolding normal prion protein, known as PrP.

They expected eggs to be more complex, but last year, Hayashi made PGCs in vitro with cells from a mouse with normal coloring and then transferred them into the ovaries of an albino mouse.

In subsequent tests, the mice with the mutation did a worse job than normal mice at learning new motor skills.

The researchers found that mutant mice lacking Del - 1 had more severe attacks of the EAE than normal mice, with more damage to myelin, the fatty sheath that coats neurons and helps in the transmission of signals along the cell.

When the researchers then induced stroke in mice either with or without the PARP gene, they found that the resulting tissue damage in the mice without the enzyme was 80 % less than in normal mice.

They then injected the protein into elderly mice with normal immune systems, and found this reproduced the beneficial effects of cord plasma on both memory performance and LTP in the hippocampus whereas mice engineered to lack TIMP2 showed reduced LTP.

Now, thanks to the new mouse model, it will be possible to study how renal tumors are able to develop in an environment with a normal immune system, and how cancer cells manage to evade the immune system's attacks.

In an article entitled «Prion protein modulates monoaminergic systems and depressive - like behavior in mice» and published in the Journal of Biological Chemistry, the group shows that mice lacking normal prions show a depressive - like behavior similar to depression symptoms found in patients with Alzheimer's and prion diseases, namely Creutzfeldt - Jakob Disease (CJD), variant Creutzfeldt - Jakob Disease (vCJD), Gerstmann - Sträussler - Scheinker syndrome, Fatal Familial Insomnia and kurIn an article entitled «Prion protein modulates monoaminergic systems and depressive - like behavior in mice» and published in the Journal of Biological Chemistry, the group shows that mice lacking normal prions show a depressive - like behavior similar to depression symptoms found in patients with Alzheimer's and prion diseases, namely Creutzfeldt - Jakob Disease (CJD), variant Creutzfeldt - Jakob Disease (vCJD), Gerstmann - Sträussler - Scheinker syndrome, Fatal Familial Insomnia and kurin mice» and published in the Journal of Biological Chemistry, the group shows that mice lacking normal prions show a depressive - like behavior similar to depression symptoms found in patients with Alzheimer's and prion diseases, namely Creutzfeldt - Jakob Disease (CJD), variant Creutzfeldt - Jakob Disease (vCJD), Gerstmann - Sträussler - Scheinker syndrome, Fatal Familial Insomnia and kurin the Journal of Biological Chemistry, the group shows that mice lacking normal prions show a depressive - like behavior similar to depression symptoms found in patients with Alzheimer's and prion diseases, namely Creutzfeldt - Jakob Disease (CJD), variant Creutzfeldt - Jakob Disease (vCJD), Gerstmann - Sträussler - Scheinker syndrome, Fatal Familial Insomnia and kurin patients with Alzheimer's and prion diseases, namely Creutzfeldt - Jakob Disease (CJD), variant Creutzfeldt - Jakob Disease (vCJD), Gerstmann - Sträussler - Scheinker syndrome, Fatal Familial Insomnia and kuru.

To determine what effect this had on fertility, Cook - Andersen's team set up an equal number of fertile male mice with 10 females lacking L2 in their eggs and 10 normal females.

Klebsiella pneumoniae is usually a normal resident in the mouth of healthy individuals, but as demonstrated in an experiment on specific pathogen - free mice treated and untreated with the antibiotic ampicillin, they can colonize in the gut and activate TH1 cells when antibiotics disturb the gut microbial balance and weaken tolerance for the colonization of oral bacteria reaching the intestine.

As a final test to see whether parasites could directly access the brain from the blood, the researchers infected mice with a mixture of normal parasites and mutants that was unable to reproduce, each labeled in different colors.

To prove that the UL6 protein sequence does in fact trigger the autoimmune attack of HSK, Cantor and his team have now infected mice with either normal HSV - 1 or a strain that they had genetically altered to lack the UL6 protein.

In experiments with genetically engineered mice that lacked beta cells, reprogrammed stomach cells pumped out insulin and glucose at normal levels in the blooIn experiments with genetically engineered mice that lacked beta cells, reprogrammed stomach cells pumped out insulin and glucose at normal levels in the blooin the blood.

Brown and colleagues also looked at whether mRGCs might also send information to the LGN in mice with normal vision.

When kept in total darkness, a mouse with a normal clock keeps a precise 23.7 - hour cycle of alternate rest and running.

Longo also knew of research by molecular biologist John Kopchick at Ohio University, which showed that mice with a mutation in their growth hormone receptor gene lived 40 percent longer than normal mice — the equivalent of an average American living to age 110.

To solve this mystery, the scientists generated mice with normal or reduced levels of A2A receptors in astrocytes and compared them on tests of learning and memory.

They found that levels of an enzyme involved in ketone metabolism, known as BDH1, were twice as high in mice with both early stage and complete heart failure compared to normal animals.

A study published January 4th in Cell Stem Cell demonstrates that a gene therapy approach can lead to the long - term survival of functional beta cells as well as normal blood glucose levels for an extended period of time in mice with diabetes.

By comparing the genome of mice with the HLHS heart defects to the genome of normal mice, Lo and her team identified several hundred mutations in the HLHS mutant strains.

With this information in hand, the researchers then performed another experiment with two more groups of normal mice that were sepWith this information in hand, the researchers then performed another experiment with two more groups of normal mice that were sepwith two more groups of normal mice that were septic.

«It was incredible to see that in adult mice, who have gone through normal development and aging, simply overexpressing Arc with a virus restored plasticity,» says co-first author Kyle Jenks, a graduate student in Shepherd's lab.

Photoswitches inserted into retinal ganglion cells (RGC) of blind mice produce much less variety of response (all evenly red means the cells fire at the same time), while blind mice with photoswitches inserted into bipolar cells (ON - BC driven) exhibit much more variety in their retinal response to light, closer to that of normal mice.

They found that the mice can develop damage to the optic nerve despite normal pressure in the eye following KPro surgery and identified TNFa and IL - 1 as inflammatory factors involved in this process, with high levels of TNFa mediating the damage to the optic nerve.

Mathias Chamaillard at the University of Lille, France, and his colleagues discovered that the skin cancer drug ipilimumab isn't as effective at treating cancer in mice born without bacteria in their gut, compared with mice with normal bacteria.

Intrigued, Turek joined with endocrinologist Joseph Bass, also at Northwestern, to study the effects of regular and high - fat diets in normal mice and mice with a dysfunctional Clock gene.

When the researchers mimicked a systemic infection in mice, animals deficient in Del - 1 were slower to begin making myeloid cells again compared to those with normal Del - 1 levels.