Sentences with phrase «in obese humans»

Discovery of a ligand that compensates for decreased endogenous agonist potency of melanocortin - 4 receptor polymorphisms identified in obese humans.

Further, the administration of dopamine agonists such as bromocriptine and methylphenidate have been shown to significantly reduce body fat and body weight in obese humans [47, 48].

Calorie Restriction - like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans Cell Metabolism 2011 (Nov 2); 14 (5): 612 — 622 ~ FULL TEXT The result of just 30 days on resveratrol were impressive: (1) The same gene regulators (AMPK, SIRT1 and PGC - 1a) were activated in this study as are activated by caloric restriction and resveratrol in mice and endurance training in humans.

Alternate day fasting increases LDL particle size independently of dietary fat content in obese humans

In obese humans, substitution of carbohydrate with protein leads to far greater weight loss, nearly twice as much.

We estimate that the percentage of macrophages in adipose tissue ranges from under 10 % in lean mice and humans to over 50 % in extremely obese, leptin - deficient mice and nearly 40 % in obese humans.

In previous studies, Chong Wee Liew, assistant professor of physiology and biophysics in the UIC College of Medicine, and his colleagues found that in obese humans TRIP - Br2 was turned - up in visceral fat but not in subcutaneous fat.

Researchers theorized that something similar might be going on in obese humans, but when they began taking blood samples, they found that obese people show very high levels of leptin.

Sucralose, when studied in obese human volunteers, raises the insulin level 22 % higher than water.

Green coffee bean extract (GCBE) also contains chlorogenic acids, and a recent study found that GCBE supplementation reduced body fat and resting heart rate in obese human subjects, though researchers weren't sure whether the caffeine content of GCBE was partly responsible.»

Not exact matches

When the researchers gave concentrated broccoli sprout extracts to 97 human type 2 diabetes patients in a 12 - week randomized placebo - controlled trial, obese participants who entered the study with dysregulated disease demonstrated significantly decreased fasting blood glucose levels compared to controls.

The large amounts of fat around the testes of obese mice, «could alter the environment and encourage epigenetic changes», says Teague, who presented the results at the 14th World Congress on Human Reproduction in Melbourne, Australia, this month.

The level of POPs needed to have an adverse affect in humans is unknown, so it should not stop obese people trying to lose weight, says Amanda Sainsbury - Salis at the Garvan Institute of Medical Research in Sydney, Australia.

The scientists are now expanding their research to larger numbers of animals and they are also planning a study to look at addiction - like behaviours in obese people to see how well their results translate to humans.

The mechanism making obese people have high blood pressure has been pinpointed in mice, so we might be able to make drugs to block it in humans

A common antioxidant found in human breast milk and foods like kiwi fruit can protect against nonalcoholic fatty liver disease (NAFLD) in the offspring of obese mice, according to researchers at the University of Colorado Anschutz Medical Campus.

«Our knowledge gained from penguins provides novel insight into the gait mechanics of humans with increased lateral movements, such as in pregnant women or obese individuals,» he says.

«Perhaps supplementing the diet of obese pregnant mothers with PQQ, which has proven safe in several human studies, will be a therapeutic target worthy of more study in the battle to reduce the risk of NAFLD in babies,» Jonscher said.

In humans, as in mice, fat cells of the obese already produced plenty of leptin — more in fact than those of their thin counterparts, since the level of leptin was directly proportional to the amount of faIn humans, as in mice, fat cells of the obese already produced plenty of leptin — more in fact than those of their thin counterparts, since the level of leptin was directly proportional to the amount of fain mice, fat cells of the obese already produced plenty of leptin — more in fact than those of their thin counterparts, since the level of leptin was directly proportional to the amount of fain fact than those of their thin counterparts, since the level of leptin was directly proportional to the amount of fat.

In the human abdominal adipose (fat) tissue of lean individuals, the amounts of Pellino3 are high, but in adipose tissue from obese individuals the levels of Pellino3 falIn the human abdominal adipose (fat) tissue of lean individuals, the amounts of Pellino3 are high, but in adipose tissue from obese individuals the levels of Pellino3 falin adipose tissue from obese individuals the levels of Pellino3 fall.

In one recent test, mice implanted with fecal microbes from thin humans stayed thin, while mice given bacteria from obese people gained weight.

In both human and laboratory studies, the offspring of mothers who are obese or consume a high - fat diet during pregnancy are much more likely to be overweight and have weight - related problems such as metabolic syndrome, diabetes and heart disease later in lifIn both human and laboratory studies, the offspring of mothers who are obese or consume a high - fat diet during pregnancy are much more likely to be overweight and have weight - related problems such as metabolic syndrome, diabetes and heart disease later in lifin life.

«If human offspring from obese mothers have a similar risk for developing fibrosis as we see in mice, we may be able to predict who is going to develop more serious disease,» said Thompson.

To explore the relevance of these results to humans, the TSRI team worked with collaborating researchers in Australia to test fat samples from obese humans and diabetics.

Artifacts from that period — the obese human and animal figurines and the phallic symbols carved in stone or bone and modeled in clay — point to the idea that the people had an obsession with the living world and its successful propagation through the descent group or lineage.

To determine how the drug works in the human brain, Mantzoros and colleagues observed 48 obese men and women — half taking the drug, half taking a placebo — over the course of a four - week experiment.

Given that adipose tissue (which makes up between 15 and 20 % of the body weight in healthy people) is a source of inflammation in obese individuals, Christine Bourgeois and Olivier Lambotte, from the University Paris SUD, France, and colleagues, decided to investigate a possible role of the adipose tissue in humans infected with HIV and in macaques infected with simian immunodeficiency virus (SIV, an HIV relative that causes AIDS - like disease in some non-human primates).

Human brains naturally shrink with age, but previous research has shown that this seems to happen more quickly in obese people.

Cytos, a biotechnology company outside of Zurich, Switzerland, is testing a different antighrelin vaccine in a clinical trial of 112 obese humans; results, says Martin Bachmann, Cytos's chief scientific officer, will be available in November.

Skeletal muscle tissue also produces increased amounts of iNOS and TNF - α in obese compared with lean rodents and humans (21, 71).

This is similar to the difference between obese and slender humans, and many researchers believe that burning more carbohydrates relative to fats can lead to fats gradually accumulating in the body.»

Since most humans with NASH are obese and insulin resistant, this represents an important difference in how MCD diets model human NASH.

Also in humans who are obese and diabetic, appear to have high expression of PTP1B.

Her team first looked at 15 obese and 20 lean Labrador retrievers two years ago, examining three genes known to affect obesity and weight in humans.

Symposia VI: Cardiovascular Benefits of Exercise: Insights from Human Studies The session will cover improving exercise tolerance in heart failure, reversal of impaired cardiac function in obese adolescents, the effect of exercise on left ventricular compliance and diastolic function in the elderly and attenuating premature cardiovascular aging in Type 2 diabetes through exercise.

«From other research, a Mediterranean - style diet, richer in MUFA (from olive or rapeseed oils) and other unsaturated oils at the expense of saturated fats, appears protective of heart disease and cancer in humans — even in overweight (but not obese) subjects.

Using targeted and whole - exome sequencing, we studied 32 human and 87 rodent obesity genes in 2,548 severely obese children and 1,117 controls.

CD36 - and GPR120 - mediated Ca2 + signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice.

In one recent study, obese rats that ate the human equivalent of two cups of wild blueberries per day for eight weeks experienced a significantly improved inflammatory response.

To investigate this effect in humans, Japanese scientists conducted a double - blind trial on obese adults with similar body weights and waist measurements in 2009.

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«National Survey data shows that the prevalence of overweight and obese adults in the U.S. has increased steadily over the past three decades», said Youfa Wang, MD, PhD, lead author of the study and associate professors with the Bloomberg School's Center for Human Nutrition.

The study, published on Feb. 3 in the journal Human Reproduction, found it may take couples in which both partners are obese up to 59 % longer to get pregnant compared to couples in the healthy weight range.

Humans: Trials Using the Intermittent Very Low Energy Approach: In overweight and / or obese populations, the majority of IER (60 - 85 % ER / alternate days) trials spanning four to 12 weeks have consistently demonstrated global improvements in cardiovascular risk markers, encompassing enhancements in glucose metabolism (described above) and lipid profiles 37 - 40, 42, 46, 49, 50 - 52 relative to baseline, which collectively would be expected to improve vascular functioIn overweight and / or obese populations, the majority of IER (60 - 85 % ER / alternate days) trials spanning four to 12 weeks have consistently demonstrated global improvements in cardiovascular risk markers, encompassing enhancements in glucose metabolism (described above) and lipid profiles 37 - 40, 42, 46, 49, 50 - 52 relative to baseline, which collectively would be expected to improve vascular functioin cardiovascular risk markers, encompassing enhancements in glucose metabolism (described above) and lipid profiles 37 - 40, 42, 46, 49, 50 - 52 relative to baseline, which collectively would be expected to improve vascular functioin glucose metabolism (described above) and lipid profiles 37 - 40, 42, 46, 49, 50 - 52 relative to baseline, which collectively would be expected to improve vascular function.

concentrations in normal - weight and obese humans New England Journal Medicine 1996; 334: 292 - 295.

Leptin levels in human and rodent: measurement of plasma leptin and ob NAN in obese and weight - reduced subjects.

The great news is that by adding fermented veggies into your foods, you are changing your gut health for better: «the composition of the gut microbiota has been shown to differ in lean and obese humans and animals and to change rapidly in response to dietary factors.

Altering the gut genome from obese to lean has «long lasting effects» when combined with a «healthy diet high in fiber and low in saturated fats,» confirming multiple studies that show «that the food we eat has a direct relationship to the types of bacteria produced in the human digestive system;»

In the human study, obese people who lost weight increased their bacteroidetes, while the numbers of firmicutes decreased.

Two studies supporting this theory — one looking at mice, the other using humans — found that a family of bacteria known as firmicutes was more plentiful in the obese (20 percent more), whereas another bacteria called bacteroidetes was almost 90 percent lower in obese subjects.