Sentences with phrase «in young mice»

To examine its effects, the researchers cut calorie intake by 40 percent in young mice and by 30 percent in middle - aged monkeys.

This was dangerous in the youngest mice, leading to early death due to failure of a digestive organ called the pancreas.

They found that the samples from the older normal mice had the most diversity of their gut microbes, including Clostridia and Bacteroides bacteria not seen in the younger mice that were still getting their nutrition entirely from mother's milk.

Members of the Villeda and Wyss - Coray labs first showed that B2M levels steadily rise with age in mice, and are also higher in young mice in which the circulatory system is joined to that of an older mouse.

The study, «Aging in mice is associated with p16 (Ink4a)- and beta - galactosidase - positive macrophage accumulation that can be induced in young mice by secreted factors of senescent cells,» will be published in print in the July issue of Aging.

This is explained by another finding from the Karsenty lab: circulating levels of osteocalcin are much higher in younger mice than in older mice.

Estradiol increased performance in young and aged mice under minimized organizational demand, but failed to improve the age - associated memory impairment and diminished performance in young mice under high organizational demand.

The drug had a potent effect — it prevented FOP extra-skeletal bone formation and also preserved limb motion and normal bone growth in young mice.

The net effect of deleting the adiponectin gene in mice is to produce higher bone mass in young mice and lower bone mass in older mice.

Interestingly, we detected upregulation of p16 and p15 in Polycomb - null skin epithelial stem cells in young mice where it is normally detected only in aged animals.

The new study shows that treating mice with a drug that promotes Klotho expression reduces the levels of Wnt5A and decreases the growth of therapy - resistant melanoma in aged mice but, importantly, not in young mice.

In these mice, administration of B2M in young mice had no significant effect, either in tests of learning or in assessments of neurogenesis.

«From other studies ***** we know that epigenetic modifications of the DPP4 gene, which are associated with an increased production of the enzyme, have a negative impact on the liver metabolism already in young mice, long before fatty liver disease emerges,» says Baumeier.

They found that Giardia and EAEC combined to increase weight loss in the young mice.

«Disruptions of splicing proteins cause facial, skin, organ defects in young mice.»

GDF - 11, which regulates the growth of spinal and olfactory (smell) receptors, is produced abundantly in young mice, but production drops off with age.

The researchers also found that SIRT1 activity in endothelial cells is critical for the beneficial effects of exercise in young mice.

The protein, growth differentiation factor 11 (GDF11), was known to regulate stem cell activity; it is abundant in young mice but its level drops as the animals age.

It restored normal blood sugar and insulin levels in animals that already had diabetes and prevented or slowed its onset in young mice that had not yet developed the disease.

Cellular - level changes to a part of the brain's reward system induced by chronic exposure to the psychoactive component of marijuana may contribute to the drug's pleasurable and potentially addictive qualities, suggests a study in young mice published in JNeurosci.

Researchers found that FTIs not only prevented cardiovascular damage in young mice, but also reversed the disease in older animals treated after the onset of arterial damage.

An experimental drug prevented learning deficits in young mice exposed repeatedly to anesthesia, according to a study led by researchers from NYU Langone Medical Center and published June 22 in Science Translational Medicine.

But THC seemed to have the opposite effect in young mice: when they were given THC, their performance in some tasks declined.

Using a technique called parabiosis, in which the vascular systems of two mice are surgically connected, Villeda's lab had previously discovered that infusing old mice with the blood of younger mice leads to brain rejuvenation, including improvements in learning and memory, while infusions of old blood cause premature brain aging in young mice.

But when the activity of RbAp48 was inhibited in younger mice, Kandel's team found that they behaved like older mice in laboratory learning tasks.

We therefore reasoned that exercise might be most likely to increase progranulin in young mice.

We did not test for aging - independent effects of rapamycin on hepatic microgranulomas, due to the relatively low prevalence of this pathology in young mice (Supplemental Table 8).

To distinguish between these possibilities, we examined whether rapamycin affects the respective phenotypes in young mice.

Systemic factors can also affect these aging - associated events, either positively in which circulating monocytes enhance remyelination in aged mice (11, 12) or negatively in which the accumulation of chemokines in old blood can reduce neurogenesis and cognition in young mice (10).

(D) Effects of rapamycin on rbc count in young mice (control, n = 9; rapamycin, n = 8).

These analyses revealed some of the same effects of rapamycin in young mice as in aging mice (decreased CD25 + CD4 + T cells; Figure 9C), whereas other effects were not present (no decrease in CD44hi T cell frequency; Figure 9E).

(D) Effects of rapamycin on RER in young mice (control, n = 9; rapamycin, n = 8).

However, rapamycin also increased exploratory activity in young mice in our study, indicative of another aging - independent effect, rather than an effect on aging per se.

The researchers also revealed that loss of Lsd1 in younger mice resulted in premature fat cell transformation.

Other studies have noted that microbiota have an important influence on the development of cognitive processes in young mice (1).

The experiment (around 1978) in which pregnant mice were given diets containing either coconut oil or unsaturated oil showed that brain development was superior in the young mice whose mothers ate coconut oil.

After 18 - month - old mice were treated with NMN for two months, their capillary density was restored to levels typically seen in young mice, and they experienced a 56 to 80 percent improvement in endurance.

«Enigmatic gene critical for a healthy brain: New research has shown how an unusual gene is needed for brain development in young mice.»

Though the Baur lab previously found that enhanced NAD synthesis does not benefit muscle performance in young mice, these new findings suggest that it may be useful for combating age - related declines in muscle function.

«The dynamics of bone growth in young mice and in children are very different from those in adults,» said Ken Kozloff, associate professor of orthopaedic surgery and biomedical engineering.

The endocannabinoid system is most active in young mice (and people), so extra THC may overstimulate it.

The results of the study are encouraging, with no reduction in midshaft bone strength or mass in young mice six weeks after treatment stopped.

«We know we can reactivate stem cells in young mice, but do older stem cells still have regenerative capacity?»

In young mice, the bones also grew slower than normal.

Although we did observe positive effects on some aging traits, such as memory impairments and reduced red blood cell counts, our studies showed that similar drug effects are also seen in young mice, indicating that rapamycin did not influence these measures by slowing aging, but rather via other, aging - independent, mechanisms.»

Knox is now testing whether the strategy is as effective at reactivating stem cells and regenerating damaged tissue in old mice as it is in young mice.