Sentences with phrase «increased osteoclast»

Previous studies suggest that microgravity activates osteoclasts, cells that control the breakdown of bone tissue, and the Medaka fish investigation examined the relationship between this increased osteoclast activity and reduced bone mineral density.

Increased osteoclast formation causes bones to become thinner and weaker.

Not exact matches

I think when there's absolute Growth hormone deficiency you may have an increase in osteoclast activity.

These products, including the major malarial by - product hemozoin, malarial proteins and as yet undefined virulence factors, induce MyD88 - dependent inflammatory responses in osteoclast and osteoblast precursors, leading to increased RANKL expression (a key molecule inducing osteoclast differentiation), and over-stimulation of osteoclastogenesis favoring bone resorption.»

The WNT7B protein had no effect on the total activity of bone - degrading osteoclasts but substantially increased the number of bone - building osteoblast cells.

Genetic analysis also revealed significant increase in activity in two genes that may be involved in mitochondria function, suggesting that osteoclast activation might be linked to the reaction of mitochondria to microgravity.

Several tumor - derived bone metastasis factors can increase RANKL production or decrease OPG secretion by osteoblasts, thereby promoting osteoclast differentiation and activation (12, 32).

He showed evidence of decreased bone volume in SMA mouse models of various severity, as well as increased fractures and osteoclast formation.

Our data raise the possibility that inhibition of ABL kinases can increase apoptosis of breast cancer cells and block osteoclast activation, which is required for osteolytic metastasis.

These findings suggest that ABL kinases promote tumor - induced osteoclast activation in part by increasing OPG abundance in osteoblasts.

IL - 6 is a multifunctional cytokine with pleiotropic functions that include inducing osteoclast activation, enhancing bone resorption, and increasing metastasis (33 — 35).

Not only does lactoferrin increase osteoblast activity, it also reduces the formation of osteoclasts, and these bone cells help to increase bone turn - over or bone loss.

The Opotowski team, which found that low vitamin A levels had as great an effect lowering BMD as did high vitamin A levels, suggested that vitamin A deficiency may contribute to increased fracture risk by allowing bone matrix to grow faster than it can be mineralized.12 Indeed, although the net effect of vitamin A is to stimulate osteoclasts and slow the growth of osteoblasts, vitamin A also causes osteoblasts to secrete a variety of enzymes and other proteins that are important to bone mineralization, including osteocalcin, which is a protein that plays a direct role in attracting and binding calcium within the bone matrix.6 By slowing the growth of the matrix but increasing the rate at which it is mineralized, adequate vitamin A helps to ensure sufficient bone density.

In addition, during puberty and into the third decade, oestrogen has an anabolic effect on the osteoblast and an apoptotic effect on the osteoclast, increasing bone mineral acquisition in axial and appendicular bone.