Sentences with phrase «inducing phosphorylation»

Antibiotic Resistance, Houston, TX, USA presentation «Adaptive Mutations in LiaR are Sufficient to Confer Daptomycin Resistance in E. faecium by Inducing Phosphorylation - Independent Activation of the LiaFSR - mediated Membra...

Western blot analyses with phospho - specific antibodies suggested that stretching induces phosphorylation of ERK of the MAP kinase pathway, but did not induce phosphorylation of phosphatidylinositol 3 - kinase.

The authors discovered that FGF2 treatment forced a high percentage of astrocytic cell - cycle re-entry via FGF receptor - induced phosphorylation of ERK and mediated the generation of self - renewing Nestin - expressing NSCs.

Huda N, Tanaka H, Mendonca MS, Gilley D. DNA damage - induced phosphorylation of TRF2 is required for the fast pathway of DNA double - strand break repair.

Furthermore; p16INK4a inhibits CDK4 and CDK6, and induces phosphorylation of the protein retinoblastoma (Rb) and liberating the transcription factor E2F which consequently result in cell cycle progression [29].

Ang1, but not Ang2, induced phosphorylation of the Tie2 downstream target AKT in BP (Fig. 1i, j) as well as in EC (Fig. 1k, l).

For example, ILPs induce the phosphorylation of AKT, which in turn phosphorylates the negative growth regulator Forkhead Box O (FoxO).

By binding to the insulin receptor, ILPs induce a phosphorylation cascade that ultimately induces growth in the target tissues [1,5,7].

In summary, our findings showed that ActD induces the phosphorylation of AKT, thereby activating AKT.

Our results showed that ActD induced the phosphorylation of AKT at Ser473 within 2 minutes.

However, the ActD - induced phosphorylation (Ser15) of p53 was not inhibited by the inhibitors of p38, JNKs and ERKs in the current study, indicating that the phosphorylation (Ser15) of p53 was independent of these three MAP kinases.

Furthermore, anti-CD3 mAb induced phosphorylation of ERK, phospholipase C γ (PLC - γ), and SLP76, all were unaltered in Gasp - deficient DP thymocytes (Fig. 5F).

Furthermore, CRF - induced phosphorylation of tau protein interferes with neuronal energetics as it impairs axonal transport of mitochondria.»

Not exact matches

In conclusion, the proteomic approach revealed that cellular stretching induced specific phosphorylation changes in chondrosarcoma cells.

In naïve cells, receptor dimerization is effectively induced by all IFNs, leading to phosphorylation of pre-associated STAT1 / STAT2 / IRF9 complexes, which subsequently form the transcription factor ISGF3.

Samelson LE, Patel MD, Weissman AM, Harford JB, Klausner RD. Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor.

Fyn membrane localization is necessary to induce the constitutive tyrosine phosphorylation of Sam68 in the nucleus of T lymphocytes.

Phosphorylation of tumor necrosis factor receptor CD120a (p55) by p42 mapk / erk2 induces changes in its subcellular localization.

LysoPCs induce Hck - and PKCδ - mediated activation of PKCγ causing p47phox phosphorylation and membrane translocation in neutrophils.

Phosphorylation of Merkel cell polyomavirus large tumor antigen at serine 816 by ATM kinase induces apoptosis in host cells.

(2017) Phosphorylation promotes activation - induced cytidine deaminase activity at the Myc oncogene.

We also show that inhibition of mTOR with rapamycin, as well as silencing mTOR gene product expression using mTOR - specific small interfering RNA, decreased phosphorylation of mTOR signaling proteins and induced cell cycle arrest and apoptosis in ALK + ALCL cells.

The results revealed that the supernatant of 72 - hour ATRA - treated NB4 cells was sufficient to induce the tyrosine phosphorylation of STAT2 and the endogenous RIG - G level in U3A cells, in comparison with the relative consistent level of total STAT2 (Fig. 3B).

Proton pump inhibitors reduce interferin - g induced neurotoxicity and STAT3 phosphorylation of human astrocytes.

The p38 - mediated p53 phosphorylation at Ser15 and subsequent p53 induction has been reported to be responsible for apoptosis induced by nitric oxide, hypoxic conditions, DNA - damaging agents, 1 - nitropyrene, and benzo [a] pyrene [30 - 32].

p38 inhibitor (SB203580) caused a minor reduction in the ActD - induced increase in the expression and phosphorylation of p53 in the 293T and Hepa - 1c1c7 cells, but not in the 293 and HepG2 cells.

Having established the importance of the miR - 181a target genes, Smad1 and Smad5, in BMP / GDF ligand - induced neurite growth, we next determined whether miR - 181a - modulated Smad phosphorylation / activation and neurite growth in SH - SY5Y cells, which are a widely used cell line model of human mDA neurons which also express the miR - 181a targets, BMPR2 and Smad1 / 5 [18,38].

Accordingly, IL - 4 can specifically induce tyrosine phosphorylation of STAT6.

The idea that both STAT2 and IRF - 9 were basic components necessary for RIG - G expression was also supported by the fact that ATRA could not only induce the total amounts of STAT2 and IRF - 9 proteins but also increase the tyrosine phosphorylation level of STAT2 in NB4 cells (Fig. 1A).

When the expression and phosphorylation patterns of HDM2 were examined, the results showed that HDM2 expression was induced by low doses of ActD (5 or 10 nM), and suppressed by high doses (> 10 nM) of ActD (Fig. 1A).

In contrast, treatment with ActD (10 nM) distinctly induced the expression and phosphorylation of p53 at 3 h, reaching a maximal response at 6 h, and maintaining a high level of p53 for up to 12 h in the HepG2 cells.

Johnson and Cole Labs uncover a new role for a tumor suppressor in DNA repair (11/15/16) Work from the Johnson lab previously showed that E2F1, a critical transcription factor target of the retinoblastoma (Rb) tumor suppressor protein, localizes to sites of both UV and IR induced DNA damage in a phosphorylation dependent manner.

Figure 7: Phosphorylation of AKT induced by actinomycin D (ActD).

p38 kinase regulates nitric oxide - induced apoptosis of articular chondrocytes by accumulating p53 via NFkappa B - dependent transcription and stabilization by serine 15 phosphorylation.

In the Hepa - 1c1c7 cells, treatment with ActD (10 nM) distinctly induced the expression and phosphorylation of p53 at 6 h, and a high level of p53 was maintained for up to 12 h (Fig. 1A).

ONC201 induced caspase - dependent apoptosis that involved activation of the integrated stress response (ATF4 / CHOP) pathway, inhibition of Akt phosphorylation, Foxo3a activation, downregulation of cyclin D1, IAP and Bcl - 2 family members.

Interferons induce tyrosine phosphorylation of the eIF2 -LCB- alpha -RCB- kinase PKR through activation of Jak1 and Tyk2

Within this broad topic we are particularly interested in characterising (i) the molecular mechanism by which these photoreceptors mediate light - dependent entrainment of the circadian clock, (ii) the components mediating, in a light - quality - dependent fashion, nucleocytoplasmic partitioning of phytochromes and UVR8, (iii) how phosphorylation and sumoylation of these photorecepors and other signalling components modulate red / far - red and UVB - induced signalling, and (iv) to what extent intercellular and cell - autonomous events contribute to phytochrome and UVR8 regulated photomorphogenesis.

Therefore, we conclude that FcεRI - induced activation of Syk is dependent on RhoH, which is essential for the phosphorylation of LAT and SLP - 76 adaptors as well as PLC phosphorylation and Ca2 + mobilization in mast cells.

In particular, our results demonstrate that LA increases reactive oxygen species levels, stimulates the phosphorylation of EGFR, ERK and c - Jun and induces the expression of c - fos.

Among the tocotrienols, γ - tocotrienol has also been shown to inhibit AKT phosphorylation, causing a reduction in NFκB activity induced by carcinogens, growth factors, and several inflammatory stimuli.1 5

Activation of the insulin receptor leads to sequential activation of a number of protein and lipid kinases, including the serine / threonine kinases Akt1 and Akt2, which not only stimulate mTOR and thus downregulate autophagic protein catabolism (and thus cysteine supplies), but elicit phosphorylation (inhibition) of FOXO1, a transcription factor that induces expression of proteins involved in both of the proteolysis recycling pathways: the autophagic / lysosomal pathway and the ubiquitin - proteasomal pathway.

Furthermore, Cy -3-g substantially induced AMPK downstream target ACC phosphorylation and inactivation, and then decreased malonyl CoA contents, leading to stimulation of CPT - 1 expression and significant increase of fatty acid oxidation in HepG2 cells.