Treatment of experimental arthritis by
inducing immune tolerance with human adipose - derived mesenchymal stem cells.
Since the liver plays a key role in
inducing immune tolerance, that protein increases the production of regulatory T cells, suppressing the immune system's attack on the body.
In this study, the researchers were able to block the autoimmune response by
inducing immune tolerance to alpha - myosin.
Inducing immune tolerance in people who have developed inhibitors is one approach.
The findings, published online in Nature Communications on July 7, support
inducing immune tolerance as a viable strategy to achieve life - long transplant survival.
If researchers can complete their 50 - year quest to
induce immune tolerance safely and selectively, the prospects for hundreds of thousands of transplant recipients would be greatly improved, and so, too, might the prospects for controlling autoimmune diseases.
The latest study builds off of work Kawai and his colleagues began fourteen years ago, when they launched the first clinical trial that attempted to use bone marrow to
induce immune tolerance for kidney recipients, to avoid the sometimes dangerous side effects of life - long immosuppressive therapy.
A key mechanism used by our body to
induce immune tolerance is by induction of regulatory T (Treg) cells, a subset of white blood cell that orders other T cells to stand down.
Not exact matches
Klinman's finding adds to growing concerns about the risk of
inducing tolerance by giving vaccines to newborns, who have immature
immune systems.
Currently, the NIAID - supported
Immune Tolerance Network is conducting a randomized trial called IMPACT to determine whether peanut OIT can lower the risk of allergic reactions, induce tolerance and change the immune responses of peanut - allergic children aged 12 to 4
Tolerance Network is conducting a randomized trial called IMPACT to determine whether peanut OIT can lower the risk of allergic reactions,
induce tolerance and change the immune responses of peanut - allergic children aged 12 to 4
tolerance and change the
immune responses of peanut - allergic children aged 12 to 48 months.
While difficult to achieve,
immune tolerance — in which a transplanted organ is accepted without long - term immunosuppression — can be
induced in some patients.
In contrast, lymphocytes in both types of endothelial cell grafts expressed higher levels of genes known to be involved in dampening the
immune response and
inducing self -
tolerance.
The study participants were injected under the skin with different doses of GAD or a placebo preparation in order to
induce immune system
tolerance to the beta cells.
A number of studies reported that HDAC inhibitors could suppress the
immune response of T cells and reduce the severity of inflammation and, therefore, might be used to inhibit
immune rejection or
induce tolerance in organ transplantation and BMT (20 — 23).
INTERPRETATION: We have developed a gene gun mediated Abeta42 gene vaccination method that is efficient to break host Abeta42
tolerance without using adjuvant and
induces a Th2
immune response.
Another potential mechanism through which iodine exacerbates or
induces Hashimoto's is by up - regulating Th17 cells, the
immune cell subset responsible for tissue destruction in autoimmune disease, and by suppressing development of regulatory T cells, the population that invokes oral
tolerance to arrest autoimmune responses (31).