Thus, as the
inflammatory cascade progresses from nonatrophic gastritis through the atrophic gastritis — intestinal metaplasia — neoplastic spectrum, it was found that these 5 specific markers were statistically significant in
predicting precancerous lesions in comparison to traditional risk
factors (receiver operating characteristic, 0.803 vs 0.580).70 As discussed previously, intestinal - type gastric cancer is more strongly associated with the atrophic gastritis and intestinal metaplasia cascade, thus explaining the closer correlation with intestinal - type gastric cancer and the serologic biopsy than diffuse - type gastric cancer.