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Inhibiting TOR boosts regenerative potential of adult tissues: Rapamycin prevents age - related loss of stem cells.»
Rapamycin is a substance that
inhibits TOR activity, inhibiting the molecule.
That's why researchers were so excited about rapamycin, a drug that
inhibits TOR, thinking it could be caloric restriction in a pill.
Not exact matches
Surprisingly, if
TOR's activity is acutely
inhibited by treatment with the therapeutic agent Rapamycin, sleep quality improves even in old flies, suggesting that age - related sleep decline is not only preventable, but also reversible.
The mutations
inhibited key molecules involved in insulin signaling (IIS) and the nutrient signaling pathway Target of Rapamycin (
TOR).
«Our hypothesis is that
inhibiting mTOR activity will shield the adult stem cells from dietary fluctuations,» said Jasper, who explained that the hypothesis is based on previous findings that showed fly stem cells went awry and got lost when
TOR activity increased in response to a high - calorie diet.
The
TOR pathway was
inhibited by expressing TSC1 / 2 in the fat body using Lsp2 - GAL4.