Sentences with phrase «insulin leads to insulin resistance»

Persistently high insulin leads to insulin resistance, which leads only to higher insulin.

Insulin leads to insulin resistance.

Persistent high levels of insulin leads to insulin resistance.

Insulin leads to insulin resistance which leads to insulin in a vicious circle.

High levels of insulin lead to insulin resistance.

Not exact matches

This can cause non-alcoholic fatty liver disease and all kinds of metabolic problems like resistance to the hormones insulin and leptin, which will ultimately lead to obesity and diabetes (13, 14, 15, 16).

Consuming too many sugars inflames our body and leads to major health issues such as unnecessary weight gain, insulin resistance, joint pain, auto - immune conditions, leaky gut syndrome and neurological degeneration.

The increased acetate in turn leads to increased food intake, setting off a positive feedback loop that drives obesity and insulin resistance, he explained.

Rapamycin, by contrast, allowed a buildup of fatty acids and eventually an increase in insulin resistance, which in humans can lead to diabetes.

«The chemicals produced by cooking meats at high temperatures induce oxidative stress, inflammation and insulin resistance in animal studies, and these pathways may also lead to an elevated risk of developing high blood pressure,» said Gang Liu, Ph.D., lead author of the study and a postdoctoral research fellow in the department of nutrition at the Harvard T.H. Chan School of Public Health in Boston.

Previous Joslin studies have demonstrated that fat cells (adipocytes) have functions far beyond fat storage: they secrete substances that actively influence metabolism and are also a site of systemic inflammation leading to insulin resistance.

Insulin resistance allows hibernating bears to break down their fat stores, and finding out how they do it could lead to therapies for type 2 diabetes

A sustained high - fat diet ensured that the process continued unabated, leading to obesity, chronic low - grade tissue inflammation and eventually, insulin resistance in the mice.

«We know that chronic inflammation leads to insulin resistance, which can then lead to diabetes.

A hallmark of many metabolic disorders and a precursor to type 2 diabetes, insulin resistance in people can lead to an overworked pancreas, excess fat storage and chronic high blood sugar.

«Vitamin D deficiency is a silent syndrome linked to insulin resistance, diabetes, rheumatoid arthritis, and a higher risk for certain cancers,» said lead author of the study Dr Emad Al - Dujaili.

«What is remarkable about our findings is that they show that a simple dietary modification of reducing the carbohydrate content of the meals can, within a day, protect against development of insulin resistance and block the path toward development of prediabetes while sustained intake of high carbohydrate diets as shown in the two mentioned studies lead to increased fasting insulin secretion and resistance.

«If we can figure out which genes influence where fat is deposited, it could help us understand the biology that leads to various health conditions, such as insulin resistance / diabetes, metabolic syndrome, and heart disease.»

And if the cells reach a tipping point where they completely block inflammation in fat tissue, they can cause fat deposits to build up inside unseen areas of the body, including the liver, leading to insulin resistance.

Researchers have long tied type 2 diabetes to chronic inflammation, caused by a ramping - up of immune system activity that ultimately damages insulin receptor signalling and leads to insulin resistance.

Insulin resistance leads to unhealthy levels of sugar in the blood and is often a predecessor to type 2 diabetes and related illnesses.

The fish «have had time to counterevolve, or coevolve, factors that allow them to negate the problems associated with poor blood glucose control, fatty livers and insulin resistance,» says Nicolas Rohner, who was a postdoctoral fellow in Tabin's laboratory and now leads his own group at the Stowers Institute for Medical Research.

«Conversely, our study shows that an increased Fas content in the liver can lead to liver steatosis and insulin resistance, even in case of a normal body weight,» Konrad explains.

These results suggest that vitamin A combined with a high - fat diet may lead to a higher body weight and increased risk of insulin resistance and diabetes.

A low sensitivity of the muscle to insulin leads to a condition called insulin resistance, which is known to be a cause of type 2 diabetes.

The low - fiber diets rapidly led to weight gain, high blood sugar, and insulin resistance in the mice.

Unlike the diet with regular soybean oil, the diet with the new GM soybean oil did not lead to insulin resistance.

As people become overweight, their skeletal muscle develops insulin resistance that can lead to type two diabetes.

Long - term insulin resistance eventually leads to diabetes.

This can eventually lead to leptin resistance, continued overeating, and an increased risk of insulin resistance, which leads to type - 2 diabetes.

A high - fat diet and obesity turn «hero» virus - fighting liver immune cells «rogue», leading to insulin resistance, a condition that often results in type 2 diabetes, according to research published today in Science Immunology.

The growing obesity epidemic is adding to the problem by leading to greater insulin resistance.

Indeed, it is very likely that insulin resistance has a key role in IAPP aggregation because insulin resistance leads to an increase in IAPP production, since IAPP and insulin are cosecreted and subjected to the same regulatory mechanisms (Höppener et al., 2000).

Her research team found that cellular oxidative stress (arising because of reactive oxygen species) increases in mice exposed to THS, damaging proteins, fats and DNA, and leading to hyperglycemia (excess glucose in the blood stream) and insulinemia (excess insulin in the blood)-- a condition also called insulin resistance.

Researchers from Uppsala University / SciLifeLab led by Tove Fall and her doctoral student Christoph Nowak have brought together plasma metabolomics data from several international cohorts to identify metabolic pathways related to insulin resistance and impaired insulin secretion.

A detectable decline in energy production by mitochondria — the organelles that are the cell's furnace for energy production — seems to be a key problem leading to insulin resistance, and thus to type 2...

A vicious cycle is then established: chronic stress results in disturbed energy homeostasis and feeding behavior (248), leading to VAT accumulation and insulin resistance, which is further aggravated by sympathetic overactivity.

4/22/2008 Fat - Cell Hormone Linked to Kidney Disease Reduced levels of a hormone produced by fat cells and linked to the development of insulin resistance may also be related to a higher risk of kidney disease, according to a study led by researchers at the University of California, San Diego School of... More...

Studies in rats have found that consuming fructose can lead to insulin resistance, resulting in diabetesANCHOR.

I should also mention that this pathway regulates lipid metabolism, and this can be then regulated in insulin resistance, and that leads to this regulation of lipids and carbohydrate metabolism.

In insulin resistance, this pathway is disinhibited and therefore it leads to hepatic glucose overproduction.

Therefore, now you have a drop in insulin levels due to inadequate secretion, and then blood sugar starts going up because of reduced insulin levels, and also insulin resistance; and that eventually leads to the development of type II diabetes.

Resistance to insulin action leads to the pancreas secreting more insulin, leading to a transient hyperinsulinemic state.

Again, these experiments clearly highlight that PTP1B could be a very important player in the development of insulin resistance, and this has actually led to a number of pharmaceutical companies developing drugs, trying to develop inhibitors of PTP1B as potential drugs for treatment of obesity and type II diabetes.

George King, M.D., studies the molecular mechanisms by which high blood glucose levels and insulin resistance may lead to long - term complications.

«In our model, stress conditions, such as a genetic variant or insulin resistance or a high - fat diet, lead to increased availability of the tribbles protein by as yet poorly understood mechanisms,» says Dr. Kulkarni, who is also an Assistant Professor of Medicine at Harvard Medical School.

Scientists have known for some time that insulin resistance and hyperinsulinemia cause increased lipids in the circulation, which indirectly leads to atherosclerosis.

The outcome of this maladaptation is a feedforward inflammatory response leading to a state of unresolved inflammation and a collection of metabolic pathologies, including insulin resistance, fatty liver, atherosclerosis and dyslipidaemia.

While caloric excess leads to insulin resistance, cardiometabolic disease and premature death, caloric restriction prevents and cures these traits.

Plus, studies have shown that chronic leucine supplementation can increase insulin resistance, which in a condition of energy surplus could lead to increased weight gain.