Sentences with phrase «irinotecan in»

Phase I / II Study to Evaluate the Safety, Efficacy, and Novel PET / CT Imaging Biomarkers of CB - 839 in Combination with Panitumumab and Irinotecan in Patients with Metastatic and Refractory RAS Wildtype Colorectal Cancer

Phase I Clinical Trial of VX - 970 in Combination with the Topoisomerase I Inhibitor Irinotecan in Patients with Advanced Solid Tumors

In a small, phase I clinical trial, Johns Hopkins Kimmel Cancer Center researchers say they show for the first time that the experimental drug guadecitabine (SGI - 110) is safe in combination with the chemotherapy drug irinotecan and may overcome resistance to irinotecan in patients with metastatic colorectal cancer.

The investigators used the nanoparticle plus the iRGD to deliver irinotecan in a robust animal model for pancreatic cancer that closely mimics human disease.

Not exact matches

The study found that carfilzomib and irinotecan have a potential synergistic effect in SCLC and other Irinotecan - sensitive cancers by allowing normal DNA damage repair and enabling normal cell - cyirinotecan have a potential synergistic effect in SCLC and other Irinotecan - sensitive cancers by allowing normal DNA damage repair and enabling normal cell - cyIrinotecan - sensitive cancers by allowing normal DNA damage repair and enabling normal cell - cycle death.

The abstract title was: CTC 11 - 001: Phase I study of Carfilzomib (C) + Irinotecan (I) in relapsed solid tumors.

Findings were presented at the WCLC are based on the updated results of 12 lung cancer patients enrolled in the clinical trial with pembro and irinotecan or gemcitabine with or without vinorelbine or docetaxel.

This causes diarrhea in up to 90 % of patients who take irinotecan.

Redinbo and his team now characterize various forms of Beta - glucuronidase produced by different strains of bacteria residing in the gut, and they show that inhibiting GI bacterial Beta - glucuronidases in mice does not affect irinotecan that is circulating in the blood and is needed to combat cancer.

Here's one example of how this information might be useful for doctors and patients: Irinotecan is a drug only indicated by the FDA for use in colon cancer.

Importantly, like cancer cells with other mutations in the HR repair pathway, CHD1 - depleted prostate cancer cells proved to be hypersensitive to chemotherapeutic drugs causing DNA breaks, such as Mitomycin C, Irinotecan and PARP inhibitors.

Drugs like fluorouracil, oxaliplatin and irinotecan work by mimicking and damaging DNA molecules, or inhibiting enzymes involved in cell and DNA replication, slowing the uncontrolled growth of tumor cells.

Metastatic colorectal cancer, the third deadliest cancer in the Unites States, is typically treated with two chemotherapy drugs, 5 - Fluorouracil in combination with either oxaliplatin or irinotecan.

Lee says the research team will measure the amount of methylation in patients» cells when they begin their treatment and the presence of genes associated with irinotecan resistance, among other possible biomarkers.

The current study was based on previous studies in the laboratory of Nita Ahuja, M.D., director of the Sarcoma and Peritoneal Surface Malignancy Program and professor of surgery at the Johns Hopkins University School of Medicine, which showed that guadecitabine limited the growth of colorectal cancer cell lines when combined with irinotecan, says Azad.

Scientists leading the new study will also look for biomarkers in patients that could help determine which of them are most likely to benefit from guadecitabine and irinotecan.

By reversing this change in cancer cells, the drug restores cancer cells» vulnerability to drugs such as irinotecan.

A Multicenter, Randomized, Open - label, 3 - Arm Phase 3 Study of Encorafenib + Cetuximab Plus or Minus Binimetinib vs. Irinotecan / Cetuximab or Infusional 5 - Fluorouracil (5 - FU) / Folinic Acid (FA) / Irinotecan (FOLFIRI) / Cetuximab with a Safety Lead - in of Encorafenib + Binimetinib + Cetuximab in Patients with BRAF V600E - mutant Metastatic Colorectal Cancer

He is the Principal Investigator of international Phase - II, randomized trial of Chimeric 14.18 or Temsirolimus in combination with Irinotecan / Temozolomide through Children's Oncology Group (COG).

This is the first study to evaluate the safety and clinical activity of the combination of oral pazopanib, intravenous or oral irinotecan, and oral temozolomide in pediatric and young adult patients with relapsed or refractory sarcomas.

One of Dr. Innocentis exemplary achievements is the elucidation of the genetic basis of severe neutropenia in cancer patients treated with irinotecan, a poster child for pharmacogenetic.

Irinotecan causes severe diarrhea and neutropenia, a decrease of white blood cells, in 20 percent to 35 percent of patients.

Ratain, for example, got his start in the field studying irinotecan, a drug used to fight colorectal cancer.

Treatment of the Gb3 - expressing gastric carcinoma cell line St3051 with STxB coupled to SN38, the active metabolite of the topoisomerase type I inhibitor irinotecan, resulted in > 100-fold increased cytotoxicity, as compared with irinotecan alone.

Weekly irinotecan and cisplatin in advanced non-small cell lung cancer: A phase II multicenter study.

36) Gao K, Lockwood WW, Li J, Lam WL, Li G (2008) Genomic analyses identify gene candidates for acquired irinotecan resistance in melanoma cells.

A new animal model of intestinal mucositis induced by the combination of irinotecan and 5 - fluorouracil in mice.

Velafermin improves gastrointestinal mucositis following irinotecan treatment in tumor - bearing DA rats

Palifermin reduces diarrhea and increases survival following irinotecan treatment in tumor - bearing DA rats