Islet transplants Insulin is normally produced by islet or beta cells in the pancreas.
Not exact matches
While these
islet cell
transplants dramatically improved blood sugar control in the short term, all but five of the 36 recipients needed additional
insulin shots within two years.
«The
transplanted islets need a lot of oxygenation and a connection to the body's circulatory system to sense the glucose levels and transport the
insulin,» noted García, who is also the Rae and Frank H. Neely Endowed Chair in Mechanical Engineering.
Combining a new hydrogel material with a protein that boosts blood vessel growth could improve the success rate for
transplanting insulin - producing
islet cells into persons with type 1 diabetes.
Diabetes researchers are considering various replacements for
insulin injections:
Transplanting new pancreatic
islet cells that make
insulin, coaxing the patient's own
islets to regenerate, or treating diabetics early in the disease with immune - suppressing therapies to prevent their body from destroying the rest of their pancreatic
islets.
Participants who still needed
insulin 75 days after
transplant were eligible for another
islet infusion.
«The loss of
insulin - producing beta cells leads to type 1 diabetes, making it an ideal target for cell replacement therapy,» said James Shapiro, MD, PhD, FRCSC, Director of the Clinical
Islet Transplant Program, University of Alberta.
The diabetic volunteer continued to produce
insulin one year after she received a
transplant of abdominal
islet cells.
To create a lasting source of
insulin - producing beta cells for
transplant, we are developing new methods to promote differentiation from pancreatic stem cells into healthy
islets.