Sentences with phrase «jnk nuclear translocation»
A p38 / JNK nuclear translocation — blocking peptide may be therapeutic in various cancers and inflammation - associated diseases.
http://stke.sciencemag.org/ Not exact matches
Together, these results support the use of the nuclear translocation of p38 and JNK as a novel drug target to treat various cancers and inflammation - induced diseases.
Previously, we determined that nuclear translocation of the MAPKs p38 and JNK involves binding to heterodimers comprising importin 3 and either importin 7 or importin 9.
The PERY peptide specifically blocked the interaction of p38 and JNK with the importins, restricted their nuclear translocation, and inhibited phosphorylation of their nuclear (but not cytoplasmic) substrates.