Regions of differentiation found within 5 Mb of centromeres were larger when compared to the rest of the genome (Meancentromeres = 339 kb; Meangenome = 225 kb; Mann - Whitney U test P < 0.07; Figure 5), and significantly more numerous since they represent ∼ 9 % of the genome and contain 22.5 % of the total number of differentiated regions (P <
Regions of differentiation found within 5 Mb of centromeres were larger when compared to the rest of the genome (Meancentromeres = 339
kb; Meangenome = 225
kb; Mann - Whitney U test P < 0.07; Figure 5), and
significantly more numerous since they represent ∼ 9 % of the genome and contain 22.5 % of the total number of differentiated
regions (P <
regions (P < 0.01).
Advances in chromosome microarray (CMA) testing narrowed the 3p25 critical
region to a 124
kb region, and recent Whole Exome Sequencing (WES) studies have suggested that the SETD5 gene contributes
significantly to the 3p25 phenotype.