Sentences with phrase «key mechanism behind»

The relationship between FOXO1 and the sirtuins, both of which are inhibited by insulin receptor signaling, may be the key mechanism behind the life - extending effects of calorie restriction with adequate nutrition (CRAN).

Yet as it turns out, the idea of starving cancer cells turns out to be a key mechanism behind some of the latest medical treatments for pNET.

Next, Lu et al. found that 3BNC117 was not effective at clearing infected cells when their Fcγ receptor was mutated or blocked, suggesting that this receptor is a key mechanism behind 3BNC117 - mediated clearance of HIV - infected cells.

«We know that most of these risk variants on their own play little role in the development of MS.. But mapping the collection of genes associated with MS represents an important advance in efforts to identify the key mechanisms behind its development,» Dr Harbo says.

This is important, because oxidative damage is believed to be one of the key mechanisms behind ageing and many diseases.

Not exact matches

The researchers behind the new study say that the fact that this mechanism is highly similar in human cells and yeast cells suggests that it plays a key role in ensuring proper chromosome distribution following each cell division.

The key to this device is not so much in its physical mechanisms but in the algorithms behind it, says neurosurgeon Edward Chang of the University of California, San Francisco.

«Novel mechanism behind schizophrenia uncovered: Pioneering study finds high - risk protein suppresses key neurotransmitter.»

Included are talks on mechanisms of aging in a wide range of established and non-traditional animal models with the key objective to enhance understanding of the basic biology behind experimental and lifestyle manipulations thought to have direct translational application to human aging.

To understand the selection mechanism behind mutations, network - based studies were used to estimate the importance of a mutated protein compared to non-mutated ones in signalling and protein — protein interaction networks.10, 11,12,13 Proteins mutated in cancer were found having a high number of interacting partners (i.e., a high degree of connectivity), which indicates high local importance.10 Mutated proteins are also often found in the centre of the network, in key global positions, as quantified by the number of shortest paths passing through them if all proteins are connected with each other (i.e., they have high betweenness centrality; hereafter called betweenness).11, 12 Mutated proteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets themselves.

The exception is this new research, published March 22 in Cell, which identifies the key cellular mechanisms behind vascular aging and the key role it plays on muscle health.

When taking a closer look at the molecular mechanisms behind this phenomena known as temperature - dependent sex determination, researchers discovered a thermosentive protein inside the egg plays a key role.

science.slashdot.org - New submitter future guy shares a report from New Atlas: A fascinating study led by scientists at the University of Zurich has uncovered key insights into the mechanisms behind how our brain generates our sense of self.