Sentences with phrase «key regulator in»

CR6 - interacting factor 1 is a key regulator in Aß - induced mitochondrial disruption and pathogenesis of Alzheimer's disease.

«Key regulator in pacemakers of our brain, heart discovered.»

The expression changes in proneural glioblastoma associated with key regulators in the regression model are consistent with in vivo expression changes in mouse PDGF ‐ driven tumors.

Not exact matches

Federal regulators are set to wave through Charter Communications» $ 55 billion bid for Time Warner Cable, with a few key conditions aimed at ensuring that the emerging video streaming industry, personified by the likes of Netflix and Hulu, can provide in future what the cable market has historically lacked: competition.

The federal government is in danger of losing the clear support of a key provincial ally in its bid to have the Supreme Court of Canada rule that Ottawa has the constitutional power to establish a national securities regulator.

The ECN hopes that the report will be a key tool for regulators across Europe and North America, for entrepreneurs, investors and any other interested stakeholders that would like to take part in shaping the future of Crowdfunding.

In 2011, federal and state securities regulators warned investors of the potential risks associated with self - directed IRAs, saying they had noted an increase in complaints about fraudulent investment schemes that used these types of IRAs as a «key feature.&raquIn 2011, federal and state securities regulators warned investors of the potential risks associated with self - directed IRAs, saying they had noted an increase in complaints about fraudulent investment schemes that used these types of IRAs as a «key feature.&raquin complaints about fraudulent investment schemes that used these types of IRAs as a «key feature.»

Important factors that may affect the Company's business and operations and that may cause actual results to differ materially from those in the forward - looking statements include, but are not limited to, increased competition; the Company's ability to maintain, extend and expand its reputation and brand image; the Company's ability to differentiate its products from other brands; the consolidation of retail customers; the Company's ability to predict, identify and interpret changes in consumer preferences and demand; the Company's ability to drive revenue growth in its key product categories, increase its market share, or add products; an impairment of the carrying value of goodwill or other indefinite - lived intangible assets; volatility in commodity, energy and other input costs; changes in the Company's management team or other key personnel; the Company's inability to realize the anticipated benefits from the Company's cost savings initiatives; changes in relationships with significant customers and suppliers; execution of the Company's international expansion strategy; changes in laws and regulations; legal claims or other regulatory enforcement actions; product recalls or product liability claims; unanticipated business disruptions; failure to successfully integrate the Company; the Company's ability to complete or realize the benefits from potential and completed acquisitions, alliances, divestitures or joint ventures; economic and political conditions in the nations in which the Company operates; the volatility of capital markets; increased pension, labor and people - related expenses; volatility in the market value of all or a portion of the derivatives that the Company uses; exchange rate fluctuations; disruptions in information technology networks and systems; the Company's inability to protect intellectual property rights; impacts of natural events in the locations in which the Company or its customers, suppliers or regulators operate; the Company's indebtedness and ability to pay such indebtedness; the Company's dividend payments on its Series A Preferred Stock; tax law changes or interpretations; pricing actions; and other factors.

Although the Chief Justice acknowledged that this argument had some merit, the more determinative factor — and the key difference between the statutory immunity provisions relied upon by the ERCB and Alberta Environment — was that the immunity clause with respect to the former explicitly contemplated the regulator as an entity («the Board or a member of the Board...») whereas the immunity provisions under the Water Act and the EPEA did not (referring only to «persons» in various capacities; see paras 62 — 71).

Important factors that may affect the Company's business and operations and that may cause actual results to differ materially from those in the forward - looking statements include, but are not limited to, operating in a highly competitive industry; changes in the retail landscape or the loss of key retail customers; the Company's ability to maintain, extend and expand its reputation and brand image; the impacts of the Company's international operations; the Company's ability to leverage its brand value; the Company's ability to predict, identify and interpret changes in consumer preferences and demand; the Company's ability to drive revenue growth in its key product categories, increase its market share, or add products; an impairment of the carrying value of goodwill or other indefinite - lived intangible assets; volatility in commodity, energy and other input costs; changes in the Company's management team or other key personnel; the Company's ability to realize the anticipated benefits from its cost savings initiatives; changes in relationships with significant customers and suppliers; the execution of the Company's international expansion strategy; tax law changes or interpretations; legal claims or other regulatory enforcement actions; product recalls or product liability claims; unanticipated business disruptions; the Company's ability to complete or realize the benefits from potential and completed acquisitions, alliances, divestitures or joint ventures; economic and political conditions in the United States and in various other nations in which we operate; the volatility of capital markets; increased pension, labor and people - related expenses; volatility in the market value of all or a portion of the derivatives we use; exchange rate fluctuations; risks associated with information technology and systems, including service interruptions, misappropriation of data or breaches of security; the Company's ability to protect intellectual property rights; impacts of natural events in the locations in which we or the Company's customers, suppliers or regulators operate; the Company's indebtedness and ability to pay such indebtedness; the Company's ownership structure; the impact of future sales of its common stock in the public markets; the Company's ability to continue to pay a regular dividend; changes in laws and regulations; restatements of the Company's consolidated financial statements; and other factors.

Important factors that may affect the Company's business and operations and that may cause actual results to differ materially from those in the forward - looking statements include, but are not limited to, increased competition; the Company's ability to maintain, extend and expand its reputation and brand image; the Company's ability to differentiate its products from other brands; the consolidation of retail customers; the Company's ability to predict, identify and interpret changes in consumer preferences and demand; the Company's ability to drive revenue growth in its key product categories, increase its market share or add products; an impairment of the carrying value of goodwill or other indefinite - lived intangible assets; volatility in commodity, energy and other input costs; changes in the Company's management team or other key personnel; the Company's inability to realize the anticipated benefits from the Company's cost savings initiatives; changes in relationships with significant customers and suppliers; execution of the Company's international expansion strategy; changes in laws and regulations; legal claims or other regulatory enforcement actions; product recalls or product liability claims; unanticipated business disruptions; failure to successfully integrate the business and operations of the Company in the expected time frame; the Company's ability to complete or realize the benefits from potential and completed acquisitions, alliances, divestitures or joint ventures; economic and political conditions in the nations in which the Company operates; the volatility of capital markets; increased pension, labor and people - related expenses; volatility in the market value of all or a portion of the derivatives that the Company uses; exchange rate fluctuations; risks associated with information technology and systems, including service interruptions, misappropriation of data or breaches of security; the Company's inability to protect intellectual property rights; impacts of natural events in the locations in which the Company or its customers, suppliers or regulators operate; the Company's indebtedness and ability to pay such indebtedness; tax law changes or interpretations; and other factors.

The aim of the study is to develop key insights for financial institutions and regulators in order to better understand the extent of its impact as they move forward in utilizing blockchain.

The search firm's news feed received an unexpected bump in the first quarter due to a crackdown by Chinese internet regulators on low - brow content, which saw several competing apps targeted during a key client - acquisition period.

The regulator has also alleged Woolworths played a key role in implementing the collusive agreement.

She and her colleagues knew that chromatin regulators — which control how genetic material gains access to a cell's transcriptional machinery — were key to treating the social deficits in ASD, but the challenge was to know how to affect key risk factors at once.

«Science is still the key strength, but on the more commercial end of the business there is a need for people who can engage with the payers and are comfortable in dealings with regulators, health technology assessment bodies such as NICE [the UK's National Institute for Health and Clinical Excellence], clinicians, and patient groups.»

In addition to its effect on the insulin pathway, the let - 7 microRNA appears to drive these metabolic and functional changes by acting on other key gene regulators.

As Dr. Walentin and Professor Schmidt - Ott have now shown, this regulator plays a key role in the development of the placenta.

But in addition to these factors, Hunt, who won a share of the 2001 Nobel Prize in physiology or medicine (along with Leland Hartwell and Paul Nurse) for his discovery of cyclin, a key regulator of the cell cycle, emphasizes early independence and playfulness.

The study identified five genes predictive of feeding success representing a range of biological systems: sensory integration (NPHP4, PLXNA1); hypothalamic regulation, a region of the brain that plays a key role in hunger signaling (NPY2R); facial development (WNT3, a gene associated with lip and palate development); and energy expenditure (AMPK, a regulator of whole body energy balance).

In particular, they are key regulators of energy and glucose.

The researchers found that mutations to a gene called ATF6, a key regulator of the unfolded protein response, can lead to achromatopsia, a hereditary visual disorder characterized by color blindness, decreased vision, light sensitivity, and uncontrolled eye movement in children.

«In this study, we show that PVT1 can be a key regulator of MYC protein, which can shift the paradigm in our understanding of MYC amplified cancers.&raquIn this study, we show that PVT1 can be a key regulator of MYC protein, which can shift the paradigm in our understanding of MYC amplified cancers.&raquin our understanding of MYC amplified cancers.»

And when researchers experimentally increased deltaFosB levels in normal mice, calbindin expression was suppressed and the animals» memory deteriorated, demonstrating that deltaFosB and calbindin are key regulators of memory.

Using newly discovered information, the researchers made significant advances in developing a family of drug candidates that target a receptor known as peroxisome proliferator - activated receptors gamma (PPARγ), a key regulator of stem cells controlling bone formation and bone resorption and a master regulator of fat.

They also found that a protein called Seven in absentia 2 (Siah2) is a key regulator of the turnover of a well - studied, clock nuclear protein called RevErbα on a 24 - hour cycle.

A key regulator of alternative splicing is the Rbfox family of proteins, which are enriched in neurons and previously were linked to neurodevelopmental disorders, including autism, schizophrenia, and epilepsy.

«The complete protection from obesity and metabolic dysfunction in the study animals, without any differences in appetite or physical activity, suggests that p75 NTR is a key regulator of fat burning.»

One key, Gibbs says, is that it is easier for the slaughterhouses to influence rancher behavior than government regulators, who are often located in distant offices.

Previously, Jonathan Tilly, a reproductive biologist at Massachusetts General Hospital in Boston, found a striking correlation between high levels of a protein called Bax (a key regulator of apoptosis) and cell death in healthy ovaries.

«New key regulator of acquisition of immune tolerance to tumor cells in cancer patients.»

«Gene regulator is key to healthy retinal development and good vision in adulthood.»

In 2001 he was jointly awarded the Nobel Prize for Physiology or Medicine for discoveries of key regulators of the cell cycle.

The study, published in Nature Communications today, focused on protein kinases, enzymes that are key regulators of cellular processes.

Furthermore, CD47 is known to be a key regulator of tissue homeostasis, and is also involved in a variety of diseases ranging from atherosclerosis to cancer.

Hsiou - Chi Liou and colleagues find that c - Rel, a lymphoid - specific member of the NF - kappaB / Rel family of transcriptional factors, is essential for B lymphocyte survival and cell cycle progression, [i] and that it is important for inducible cytokine and cytokine receptor expression and a key regulator of early activation and proliferation in T cells.

In addition, a number of key developmental regulators were expressed at higher levels in bsl1 - 1 mutants, including orthologs of classical genes from maize that specify AM identity and determinacy (e.g., bd1 [Chuck et al., 2002] and ramosa1 [Vollbrecht et al., 2005]-RRB-, that pattern lateral organ development (e.g., narrow sheath1 [Scanlon et al., 1996] and yabby10 [Juarez et al., 2004]-RRB-, and those implicated in carpel repression in maize tassels (e.g., grassy tillers1 [Whipple et al., 2011], tasselseed 1 [Acosta et al., 2009], and tasselseed 2 [Irish and Nelson, 1993]-RRB-(Table 2In addition, a number of key developmental regulators were expressed at higher levels in bsl1 - 1 mutants, including orthologs of classical genes from maize that specify AM identity and determinacy (e.g., bd1 [Chuck et al., 2002] and ramosa1 [Vollbrecht et al., 2005]-RRB-, that pattern lateral organ development (e.g., narrow sheath1 [Scanlon et al., 1996] and yabby10 [Juarez et al., 2004]-RRB-, and those implicated in carpel repression in maize tassels (e.g., grassy tillers1 [Whipple et al., 2011], tasselseed 1 [Acosta et al., 2009], and tasselseed 2 [Irish and Nelson, 1993]-RRB-(Table 2in bsl1 - 1 mutants, including orthologs of classical genes from maize that specify AM identity and determinacy (e.g., bd1 [Chuck et al., 2002] and ramosa1 [Vollbrecht et al., 2005]-RRB-, that pattern lateral organ development (e.g., narrow sheath1 [Scanlon et al., 1996] and yabby10 [Juarez et al., 2004]-RRB-, and those implicated in carpel repression in maize tassels (e.g., grassy tillers1 [Whipple et al., 2011], tasselseed 1 [Acosta et al., 2009], and tasselseed 2 [Irish and Nelson, 1993]-RRB-(Table 2in carpel repression in maize tassels (e.g., grassy tillers1 [Whipple et al., 2011], tasselseed 1 [Acosta et al., 2009], and tasselseed 2 [Irish and Nelson, 1993]-RRB-(Table 2in maize tassels (e.g., grassy tillers1 [Whipple et al., 2011], tasselseed 1 [Acosta et al., 2009], and tasselseed 2 [Irish and Nelson, 1993]-RRB-(Table 2).

In this presentation, special emphasis will be given to the role of Ca2 + handling as a key regulator of (i) muscle weakness and (ii) beneficial adaptations observed after high intensity interval training.

In rice, Oryza sativa HOMEOBOX1, a key regulator of meristem maintenance similar to kn1 from maize, controls local BR accumulation by directly targeting and upregulating genes encoding BR catabolism and conjugation enzymes (Tsuda et al., 2014).

He served as a member of the graduate faculty in the Department of Molecular Biology at Princeton University and spent 10 years at NIH where he madesignificant contributions to the discovery of a class of proteins known as tyrosine kinase oncogenes as key regulators of the immune system.

«It is in the spirit of common purpose that we express our disappointment that the Department has apparently chosen not to make this review — which as outlined in your memo has the potential to upend energy markets around the country — public and open to input from industry, grid operators, state regulators, and other key stakeholders.»

We identified homozygous inactivating mutations in RAB3GAP, encoding RAB3 GTPase activating protein, a key regulator of the Rab3 pathway implicated in exocytic release of neurotransmitters and hormones, in 12 families with Micro syndrome.

«IL - 28B is a key regulator of B - and T - Cell vaccine responses against influenza» by Adrian Egli et al. published in PLOS Pathogens on Thursday 11 December 2014.

Title: A genome - wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation (IN PRESS, Oct 2012) Authors: Sharrocks A, Yang S - H, Kalkan T, Haslam C, Smith A Date: IN PRESS, Oct 2012 Publication Details: PLoS Genetics

DEC1 / STRA13 is a key negative regulator of activation - induced proliferation of human B cells highly expressed in anergic cells

Scientists discover that a regulator of inflammation plays a key role in the proliferation of lung cancer cells

As shown in 1A, similar to hESCs, hNSCs express high levels of SOX2, which is considered a key regulator of pluripotency [19], and NESTIN, a protein specific to NSCs [21]--[23].

The research demonstrates that bioactive lipids have the ability to regulate inflammatory immune cells in the retina, key regulators of the angiogenic process in this disease.

These experimental data establish the retromer complex as a key spatiotemporal regulator of IFNAR endosomal sorting and a new factor in type - I IFN - induced JAK / STAT signalling and gene transcription.

Not restricted to its spiny namesake, this signaling pathway, which is a key regulator of animal development, is present in all bilaterians (or animals that are bilaterally symmetrical — which is most animals, including humans).