Sentences with phrase «key studies in mice»

Key studies in mice showed that NF - κB can mediate immune rejection of tumors.

Not exact matches

Studies involving mice also helped to answer a key question: What turns on the activity of the per and tim genes in the first place?

In this study, Cherqui's team transplanted wildtype HSPCs into an FA mouse model, reporting that the HSPCs engrafted and soon differentiated into macrophages in key regions of the mice's brain and spinal cord where they appeared to transfer wildtype FXN into deficient neurons and muscle cellIn this study, Cherqui's team transplanted wildtype HSPCs into an FA mouse model, reporting that the HSPCs engrafted and soon differentiated into macrophages in key regions of the mice's brain and spinal cord where they appeared to transfer wildtype FXN into deficient neurons and muscle cellin key regions of the mice's brain and spinal cord where they appeared to transfer wildtype FXN into deficient neurons and muscle cells.

Studying aging and its associated diseases has been challenging because existing vertebrate models (e.g., mice) are relatively long lived, while short - lived invertebrate species (e.g., yeast and worms) lack key features present in humans.

Samer Hattar, a neuroscientist at Johns Hopkins University in Baltimore, Maryland, and lead author on the Neuron paper, says he isn't convinced that the study proves that mRGCs are a key component of conscious vision in mice with functional rods and cones.

Years of diabetes research carried out on mice whose DNA had been altered with a human growth hormone gene is now ripe for reinterpretation after a new study by researchers at KU Leuven confirms that the gene had an unintended effect on the mice's insulin production, a key variable in diabetes research.

Our lungs are A-list stars at detecting oxygen, but a new study in mice suggests that the skin may be a key supporting actor.

In a key memory experiment in the study, mice brains were injected with beta - amyloid, whose increase is one hallmark of Alzheimer's in humanIn a key memory experiment in the study, mice brains were injected with beta - amyloid, whose increase is one hallmark of Alzheimer's in humanin the study, mice brains were injected with beta - amyloid, whose increase is one hallmark of Alzheimer's in humanin humans.

Exactly what happens in the uterus to transmit this risk still isn't clear, but a new study on mice points to the placenta as a key actor.

In a companion study also published in Science, Nick Haining, MD, and colleagues from Dana - Farber Cancer Institute, also found a distinct epigenetic landscape for exhausted T cells in mice and humans, and they were able to ascribe key functions in T cell exhaustion to some of these epigenetic changeIn a companion study also published in Science, Nick Haining, MD, and colleagues from Dana - Farber Cancer Institute, also found a distinct epigenetic landscape for exhausted T cells in mice and humans, and they were able to ascribe key functions in T cell exhaustion to some of these epigenetic changein Science, Nick Haining, MD, and colleagues from Dana - Farber Cancer Institute, also found a distinct epigenetic landscape for exhausted T cells in mice and humans, and they were able to ascribe key functions in T cell exhaustion to some of these epigenetic changein mice and humans, and they were able to ascribe key functions in T cell exhaustion to some of these epigenetic changein T cell exhaustion to some of these epigenetic changes.

In one of the studies, a team led by immunologist Mark Pepys of the Royal Free and University College Medical School in London, United Kingdom, treated mice with a protein from cobra venom that sops up a key complement proteiIn one of the studies, a team led by immunologist Mark Pepys of the Royal Free and University College Medical School in London, United Kingdom, treated mice with a protein from cobra venom that sops up a key complement proteiin London, United Kingdom, treated mice with a protein from cobra venom that sops up a key complement protein.

Next, studies involving germ - free mice (that is, mice that lack microbes) and other research uncovered ties between these microbes, our so - called microbiota, and health — with bacteria playing potentially key roles in immunity, obesity, and development.

«Natural killer cells help to drive inflammation, insulin resistance: Study in mouse models of diabetes identifies key immune mechanisms in abdominal fat.»

The FDA - approved drug fluoxetine, also known by the brand name Prozac, restored levels of a key neurotransmitter and improved behavior in mice with an autism - like disorder, a new study in the June 21 issue of Science Advances reports.

While it doesn't provide an easy cure for hair loss, the study does uncover a key component of the genetic wiring behind hair growth in both mice and men.

Next, in mouse studies, the scientists deleted key genes, called Atg7 or Atg5, whose function was necessary for autophagy in regulatory T cells.

In the present study, the scientists created a genetically mutant mouse model deficient in type 1A BMP - receptor (BMPR1A), a key receptor for BMP - 7 which has been shown to be associated with obesity in human populationIn the present study, the scientists created a genetically mutant mouse model deficient in type 1A BMP - receptor (BMPR1A), a key receptor for BMP - 7 which has been shown to be associated with obesity in human populationin type 1A BMP - receptor (BMPR1A), a key receptor for BMP - 7 which has been shown to be associated with obesity in human populationin human populations.

Correspondingly, endothelial - specific deletion of Tie2 using Ve - cad - Cre driver mice, pursued in validating the Tie2fl / fl mice used in this study, essentially phenocopied the global Tie2 KO phenotype with embryonic lethality around E10.5 (Supplementary Fig. 13), confirming the key role of endothelial Tie2 during embryonic development.

The ICS is a large - scale facility open to the community that ensures the generation of mouse models à la carte, the validation of genetic models, the expansion and preservation and distribution of models with the housing department, and offers in its phenotyping department a series of standardized functional analysis of mouse models that can be performed in a comprehensive pipeline or on demand, as well as for more specialized studies, that cover the major functions and key physiological systems.

The finding is based on studies of mice with altered levels of the growth factor PDGF in neural stem cells, which play a key role in the development of the eye.

Some studies have identified a number of regions of methylated DNA (one key way in which epigenetic changes occur) that are different in fat cells of mice fed high - fat diets than in cells of mice with normal diets.

December 13, 2010 — A protein lost in Alzheimer's disease may play a key role in memory development, according to a new study in mice.

For example, transgenic mice lacking dopamine, a key brain chemical for motor control, provide an integral animal model for studying the changes in brain dynamics during the induction and recovery from an induced Parkinsonian state.

In a study published in the Journal of Agriculture and Food Chemistry, mice fed a high - fat diet along with acetic acid — vinegar's key component — developed up to 10 % less body fat than control rodentIn a study published in the Journal of Agriculture and Food Chemistry, mice fed a high - fat diet along with acetic acid — vinegar's key component — developed up to 10 % less body fat than control rodentin the Journal of Agriculture and Food Chemistry, mice fed a high - fat diet along with acetic acid — vinegar's key component — developed up to 10 % less body fat than control rodents.