Not exact matches
The biotech companies and the scientists who purchased the
kits largely ignored the possibility that their antibodies might be cross-reacting with other proteins and thus overestimating levels of
irisin, Erickson said.
Furthermore, none of the proteins detected by these test
kits in any human or animal blood samples were the correct size to be
irisin.
The researchers believe that their findings dispute all previous data obtained with commercial ELISA
kits for
irisin and make it unlikely that the hormone plays a physiological role in humans.
The discovery of the «exercise hormone»
irisin three years ago and more than 170 related papers about it since have been called into question by recent research showing they were based on flawed testing
kits.
These researchers argue that the
irisin levels reported by commercial
kits were actually due to unknown blood proteins, misconstruing the role of the hormone in human metabolism.