Sentences with phrase «l1 blockade»

Iwai Y, Ishida M, Tanaka Y, Okazaki T, Honjo T, Minato N. Involvement of PD - L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD - L1 blockade.

E. John Wherry, PhD, director of the Institute for Immunology at Penn and the Barbara and Richard Schiffrin President's distinguished professor of Microbiology, in the Perelman School of Medicine at the University of Pennsylvania, and colleagues found that reinvigorating exhausted T cells in mice using a PD - L1 blockade caused very few T memory cells to develop.

However, this epigenetic pattern was only minimally changed following the PD - L1 blockade.

In addition, they found that PD - L1 blockade increased virus production in the cell culture from such patients.

In contrast, PD - L1 blockade increased the capacity of Treg cells to multiply (and hence their overall numbers), but only in cells from patients with viremia, i.e. those that had detectable virus in their blood.

Not exact matches

They found that PD - L1 immune checkpoint blockade significantly improved the therapeutic efficacy of stem cell based oncolytic virotherapy in melanoma brain metastasis.

Immunologic checkpoint blockade with anti — cytotoxic T - lymphocyte — associated antigen 4 (CTLA - 4) or anti — programmed death 1 (PD - 1) / programmed death ligand 1 (PD - L1) agents seems to have some degree of clinical efficacy in advanced mucosal melanoma, although data are limited to smaller retrospective series or subset analyses of prospective trials.

He showed that engagement of PD - 1 by PD - L1 or PD - L2 inhibited T cell activation, cytokine production, and cytolytic activity whereas blockade enhanced these activities.

«We hope this could be developed into a clinical trial testing a combination of PD - L1 and PD - 1 blockade with epigenetic therapy.

Zou's group was the first to show PD - L1 expression, regulation and functional blockade in dendritic cells in the human cancer microenvironment.