T - cells (red, yellow, and blue) attack a tumour in a mouse model of breast cancer following treatment with radiation and a PD -
L1 immune checkpoint inhibitor, as seen by transparent tumour tomography.
The study compared four PD - L1 IHC diagnostic assays developed in conjunction with four PD - 1 / PD -
L1 immune checkpoint inhibitors, which are used in NSCLC clinical trials.
Not exact matches
The cancer cells» defense strategy can be overcome by
immune checkpoint inhibitor agents, including anti-PD-1 / PD -
L1 antibodies, several kinds of which have received fast - track approval from the U.S. Food and Drug Administration (FDA).
Checkpoint inhibitors are monoclonal antibodies that target certain proteins that downregulate the
immune system, such as programmed cell death protein 1 (PD - 1), programmed death - ligand 1 (PD -
L1) and cytotoxic T - lymphocyte antigen 4 (CTLA - 4).
Commenting on the two studies, Baas says that finding a good treatment for mesothelioma has been a challenge for many years and has so far led to many disappointments, so there is a need for investigation into new pathways such as the use of
immune checkpoint inhibitors that target the PD - 1 / PD -
L1 pathway.
PD - 1 / PD -
L1 inhibitors belong to the family of «
immune checkpoint inhibitors» — a type of immunotherapy that helps in controlling the body's
immune response to cancer.