Sentences with phrase «l1 positive tumors»

While this trial - s primary efficacy goals are to evaluate anti-tumor activity in PD - L1 positive tumors, preliminary exploration of antitumor activity will also be conducted in a subset of PD - L1 negative tumors based upon response observed in PD - L1 positive tumors or lymphoma in this trial.

Provide example data from experiments using PD - L1 positive tumors and a cancer cell - line engraftment into a humanized mouse model that was used to test anti-PD1 immune therapy

Not exact matches

Patients in the trial had advanced NSCLC, and their tumors tested positive for PD - L1 levels of 50 % or more.

«Interestingly, we found that activity of pembrolizumab was seen in both PD - L1 - positive and - negative tumors.

The trial investigated the drug in two separate cohorts of patients: Cohort A, which included 170 patients with heavily pretreated metastatic triple negative breast cancer (mTNBC) regardless of PD - L1 expression, and Cohort B, which included 52 patients with PD - L1 - positive tumors who received it as first - line therapy.

A Phase I / II Study of Pembrolizumab (MK - 3475) in Children with Advanced Melanoma or a PD - L1 Positive Advanced, Relapsed or Refractory Solid Tumor or Lymphoma