Sentences with phrase «lif promotes»

Not exact matches

Using NPCs, Silva et al. delineated two phases in the reprogramming process (pre-pluripotency and ground state pluripotency) and demonstrated that dual inhibition (2i) of mitogen - activated protein kinase (MAKP) signaling and glycogen synthase kinase - 3 (GSK3) signaling combined with the self - renewal cytokine leukemia inhibitory factor (LIF) promotes pre-pluripotent cells to ground state pluripotency [19].

For instance, the role of LIF - gp130 - Stat3 axis in promoting ES cell proliferation is particularly well - defined [1], [3], and BMP - induced differentiation signals are inhibited by a Nanog - Smad1 protein complex [4]; crosstalk between these pathways has also been reported [5].