Turmeric has been found to down regulate inflammatory enzymes known as the COX and
LOX enzymes (5).
UC - II doesn't work by suppressing the COX or
LOX enzymes, though.
It's thought that by targeting
the LOX enzymes you can mitigate some of the side - effects seen with NSAIDs like ulceration and curcumin, being a
It's thought that by targeting
the LOX enzymes you can mitigate some of the side - effects seen with NSAIDs like ulceration and curcumin, being a dual inhibitor, has been noted to have comparatively less gastrointestinal side - effects compared to NSAIDs potentially due to this.
Boswellia works mostly through suppressing
the LOX enzymes mentioned in the curcumin section.
Boswellia inhibits 5 -
LOX enzyme.
Not exact matches
Curcumin can inhibit both the activity and the synthesis of cyclooxygenase - 2 (COX2) and 5 - lipoxygenase (5 -
LOX), as well as other
enzymes that have been implicated in inflammation.
LOX is a comprised of copper
enzyme that cross-links collagen and elastin; a lack of the compound has been linked to aortic aneurysm risk in humans.
To help prevent such conditions, Iyer and colleagues at The University of Western Australia, Fiona Wood Foundation and Royal Perth Hospital Burns Unit, together with Pharmaxis Ltd., (all in Australia) are studying compounds that inhibit an
enzyme called lysyl oxidase, or
LOX.
For example, research findings have documented the ability of betalains in Swiss chard to inhibit activity of pro-inflammatory
enzymes like cyclo - oxygenase (COX) and lipoxygenase (
LOX).
However, rather than just being «another thing it does» boswellia is much more potent on these
enzymes, specifically 5 -
LOX, and can also inhibit nF - kB, a master regulator of inflammation.
Boswellia Extract: Clinical studies have shown boswellia to lower levels of inflammatory markers by modulating the production of pro-inflammatory
enzyme 5 -
LOX, which is common in joint discomfort and other inflammation - related concerns.
In metabolic terms, this activity of flavonoids involves the inhibition of cyclo - oxygenase (COX) and lipoxygenase (
LOX)
enzymes.
In the normal workaday world of the body, this is no big deal, but when you overload the system it overcreates
enzymes known as 5 -
LOX, COX - 1 and COX - 2.