Sentences with phrase «lxxll nuclear receptor»

In the course of this work, Burris and Flaveny have explored the roles of the nuclear receptor REV - ERB, which regulates key processes in the body, from sleep to cholesterol, and, most recently, muscle regeneration.

«Scientists slow progression of fatal form of muscular dystrophy: Hope lies in nuclear receptor that regulates muscle.»

Thomas Burris, Ph.D., chair of pharmacology and physiology at Saint Louis University and Colin Flaveny, Ph.D., assistant professor of pharmacology and physiology at SLU, study natural hormones that regulate nuclear receptors.

Center for Nuclear Receptors & Cell Signaling (CNRCS) Assistant Professor Daniel Frigo and his research team recently published a study investigating the processes through which androgen receptors affect prostate cancer progression.

The team knocked out the gene for a protein called nuclear receptor corepressor 1 (NCoR1) in the muscles of mice.

A team of researchers led by Tokyo Medical and Dental University (TMDU) previously found that upon the onset of lactation after birth, milk lipids serve as a ligand to activate the nuclear receptor peroxisome proliferator - activated receptor (PPAR) α, which is a key transcriptional regulator of liver fat metabolism.

They discovered that a nuclear receptor protein, estrogen - related receptor γ (ERRγ), occurred in much larger amounts in adult beta cells.

«Strikingly, treatment with a steroid hormone called Δ7 - dafachronic acid, a chemical that binds to a parasite nuclear receptor called Ss - DAF - 12, significantly reduced the worm burden in MPA - treated mice,» Dr. Mangelsdorf said.

Originally, however, they were not examining brown fat thermogenesis, but instead were looking for clues to the function of ERRβ, a protein about which little was known at the time, except that it was closely related to ERRα, appeared in brown fat cells, and also worked as a so - called nuclear receptor — a molecular switch for gene activation that can be turned on by small lipophilic molecules or a signaling protein partner.

The study focused on a small subset of nuclear receptors, a large family of proteins that regulate gene expression in response to signals from various binding partners, including steroids and fats.

Therapeutic drugs can also be made to fit these pockets, switching the nuclear receptor on or off to alter gene expression.

Like other nuclear receptors, HNF - 4α has a pocket that binds natural signaling molecules or could be targeted with synthetic drugs.

HNF - 4α is a special type of protein called a nuclear receptor.

Molecular determinants of crosstalk between nuclear receptors and Toll - like receptors.

His team has made potent and selective chemical probes for orphan nuclear receptors widely available in the scientific community.

He led the Glaxo program on orphan nuclear receptors that uncovered their role in regulation of human metabolism and was co-discoverer of obeticholic acid, a breakthrough medicine for liver diseases targeting FXR.

Title: A genome - wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency Authors: Guo G, Smith A Date: October 2010 Publication Details: Development.

These researchers gave the mice synthetic agonists to certain nuclear receptors that are involved in controlling expression of circadian clock proteins...

In April 2009 Anouk started her PhD research on «the role of Nuclear receptor Nur77 during inflammation» at the department of Medical Biochemistry of the Academic Medical Center (AMC) Amsterdam in The Netherlands under the supervision of Prof. Carlie JM de Vries and received her degree in February 2015.

It is a required coactivator of TGF - beta, Notch and nuclear receptor genes.

Although Nurr1 is a ligand - independent nuclear receptor, Dr. Kim hypothesizes that Nurr1 may have endogenous ligand (s) and is pursuing to identify and characterize potential Nurr1's endogenous ligand (s).

Dr. Kim and his group work to identify the defective components from these cells — like the orphan nuclear receptor Nurr1, which is critical for dopamine neurons and inflammation — in order to understand and reverse the damage.

Based on basic transcriptional studies of midbrain dopamine neurons, Dr. Kim's lab identified the orphan nuclear receptor Nurr1 as a potential drug target of Parkinson's disease (PD) to develop novel drug candidates for neuroprotective and mechanism - based therapeutics.

Full Citation: The orphan nuclear receptor Nr4a1 couples sympathetic and inflammatory cues in CNS - recruited macrophages to limit neuroinflammation.

ATRA has been generally known to exert its roles through their nuclear receptors.

A Dominant Mutation in Nuclear Receptor Interacting Protein 1 Causes Urinary Tract MalformationsDysregulation of Retinoic Acid Signaling.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

Dissection of the LXXLL nuclear receptor - coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta

The aryl hydrocarbon receptor (AHR) is a widely expressed nuclear receptor that senses environmental stimuli and modulates target gene expression.

The vitamin D receptor belongs to the nuclear receptor superfamily of steroid / thyroid hormone receptors, and VDRs are expressed by cells in most organs, including the brain, heart, skin, gonads, prostate, and breast.

The vitamin A — RXR - alpha complex «dimerizes» with these other nuclear receptors, forming a new complex that acts as a transcription factor to turn on gene expression.

It reacts with nuclear receptors in DNA which causes protein synthesis and develops growth hormone.

Vitamin A binds to two types of nuclear receptor, RAR and RXR.

This carries the message of binding to the nuclear receptors.

Furthermore, it communicates with DNA nuclear receptors to assist in the synthesis of protein.

Yet current research out of the Nuclear Receptor Signaling Journal shows that SARMs can have an extremely significant effect on the medical industry as a whole, Ostarine was found to be highly effective in the protection of bone mass, the enlargement of bone mass and the aiding with fat loss.

But it's a hormone that doesn't have the same type of stimulation that thyroid hormone does at the nuclear receptor site level.

by regulating number of nuclear receptors such as histone deacetylases (HDAC) and peroxisome proliferator activated receptors (PPAR) that control glucose, fatty acids and cholesterol and have significant effects on the brain cholesterol homeostasis and amyloidosis.

Dietary fibre modifications that are low in fat and glucose reduce the risk for AD by not only effecting cell membranes and nutrient sensing G coupled receptors but also by regulating number of nuclear receptors such as histone deacetylases (HDAC) and peroxisome proliferator activated receptors (PPAR) that control glucose, fatty acids and cholesterol and have significant effects on the brain cholesterol homeostasis and amyloidosis.

Naringenin, a chemical found in grapefruit and in other citrus fruits, activates proteins called nuclear receptors that cause the liver to break down fatty acids, study researchers from Hebrew University of Jerusalem and Massachusetts General Hospital in Boston said in a statement.

Not exact matches

The study, «The nuclear transport receptor Importin - 11 is a tumor suppressor that maintains PTEN protein,» which will be published online February 13 in The Journal of Cell Biology, suggests that the loss of Importin - 11 may destabilize PTEN, leading to the development of lung, prostate, and other cancers.

In collaboration with the University of Texas Southwestern Medical Center (UTSW) in Dallas, the researchers found that the tumor - suppressive activity of geranylgeraniol was accompanied by down - regulation of HMG CoA reductase, a key enzyme in the mevalonate pathway that provides essential intermediates for the posttranslational modification of growth - related proteins such as Ras, nuclear lamins and insulin - like growth factor receptors.

She obtained her Ph.D. from Ulster University in Northern Ireland, United Kingdom, studying the activity of nuclear - receptor transcription factor pathways in cancer.

Using Positron Emission Tomography (PET) from nuclear medicine, it is possible to quantify receptors, transporters and enzymes, in order to diagnose neurochemical differences in brain disorders but also to make a detailed analysis of the effects a drug has on the brain.

The predictors include «Online Mendelian Inheritance in Man» (OMIM, a list of genetically caused diseases), receptors, kinases, growth factors, transcription factors, tissue specific, plasma membrane localization, nuclear localization and conversation index.

They later showed that RORA, a nuclear hormone receptor that functions as a transcription factor, can potentially regulate the transcription of more than 2,500 genes, including over 400 genes already associated with autism.

Determination of structure - substance and substance - receptor relations with nuclear magnetic resonance or x-ray spectroscopy.

The mechanisms by which TZDs exert these effects on glucose and lipid metabolism are not completely defined, though many of their actions appear to be mediated through activation of the nuclear hormone receptor PPAR - γ.

A recent innovation in breast cancer biomarkers seeks the HER3 receptor instead, which could mean more comprehensive breast cancer imaging and potential treatments, say experts presenting data during the Society of Nuclear Medicine and Molecular Imaging's 2014 Annual Meeting.

The data show that lipid processing and metabolism are coupled to immune responses via the activity of nuclear hormone receptors.