(D)
Large pigmented cells are observed in the subretinal space at 13 week post-graft.
Not exact matches
In people with severe eye disease, transplants made from embryonic stem
cells (in region of black dotted circle) appear safe, and became
larger and more
pigmented over time (right).
Xeno - Free and Defined Human Embryonic Stem
Cell - Derived Retinal
Pigment Epithelial
Cells Functionally Integrate in a
Large - Eyed Preclinical Model
The
large pigmented CD68 - positive
cells observed in the subretinal space at 13 weeks are likely to be macrophages / microglia filled with melanin [46], [47] from the transplanted human iPS - RPE
cells.
At 13 weeks, two distinct CD68 - positive
cell populations were observed, one type was small and non-
pigmented (Fig. 8C) and the other consisted of
large highly
pigmented cells (Fig. 8 D).
In addition, two copies of the M allele
large enough to produce the merle coat color are thought to cause the death of skin melanocytes, retinal
pigment cells, and melanocytes of the inner ear which can result in significant white areas of the coat, eye abnormalities and deafness.