Sentences with phrase «larger trials with»

Larger trials with stricter safety measures have demonstrated that with a cautious protocol, breech birth can be conducted safely in appropriately supported obstetrical units.

«Although it should be validated with a larger trial with more robust clinical endpoints,» he added, «given the pharmacoeconomic implications, these data warrant consideration by prescribers, payers and patients.»

AUDIO SOT / FULL Super @: 41 Jon O. Ebbert, M.D., M.Sc., — Mayo Clinic Runs: 06 «We were interested in doing a larger trial with Varenicline including a longer duration of therapy.»

«Although it should be validated with a larger trial with more robust clinical endpoints, given the pharmacoeconomic implications, these data warrant consideration by prescribers, payers and patients,» Szmulewitz said in a university news release.

Not exact matches

While the new mid-stage study results from DNDi were impressive (they showed cure rates of 96 % to 97 % even for the sickest patients and those with liver scarring), more late - stage trials will be necessary before the drug is available on a large scale in the developing world.

Currently in the U.K., he will go back to Privateer's headquarters in Seattle, then visit Tilray's 60,000 - square foot facilities in British Columbia, Canada, then to Australia, where Tilray has an import license to send marijuana for a clinical trial with a chemotherapy - induced nausea and vomiting study with the University of Sydney, the government of New South Wales and the country's largest cancer hospital.

Following preliminary clinical trials, the company is now in discussion with a major New York City hospital to integrate Fever Smart into a large clinical research program.

GUMC says its researchers are now planning larger clinical trials with nilotinib for patients with Parkinson's and other similar diseases including Alzheimer's disease, likely to begin in 2016.

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These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Announced a clinical trial collaboration with Pfizer, Inc. (Pfizer) to evaluate the safety and efficacy of the investigational combination of Yescarta and Pfizer's utomilumab, a fully humanized 4 - 1BB agonist monoclonal antibody, in patients with refractory large B - cell lymphoma.

We talk with two pioneering physicians — one of whom is overseeing the world's largest HIV vaccine trial and the other led a groundbreaking successful pilot in the U.S. — to see how far we are from getting to zero.

Trial lawyers like Schlichter are winning 401k fee lawsuits and cashing in with large settlements.

Some of Japan's largest companies, including Samsung and Deutsche Telecom, picked up on Evernote's loyal following and began preloading their devices with the platform, shelling out huge sums to offer their customers pre-paid one - year Evernote trials.

One of Juno's rivals, Kite Pharma, yesterday said it had completed its enrollment of 72 patients with diffuse large B - cell lymphoma in the Phase II portion of the ZUMA - 1 trial, designed to assess KTE - C19.

Dr. Newman added that rival CAR T cell therapy developer Kite Pharma was still likelier to generate more revenue than Juno with KTE - C19, which last week completed patient enrollment in the Phase II portion of the ZUMA - 1 trial in patients with diffuse large B - cell lymphoma.

If myelofibrosis trial results are consistent with previous observations, the healthcare behemoth will help fund larger trials in order to support New Drug Applications.

Recent sex discrimination cases resulting in large settlements, in some cases awards of multi-million dollars, to be split with aggressive trial attorneys, are the latest examples of misusing the Civil Rights Act of 1964.

Biblical inerrancy is debated in America's largest denomination with the same vigor, and in almost the precise terms, that it was in the 1890s Charles Briggs trial.

Our highly skilled technicians combined with our laboratory - scale processing equipment reduce the need for large plant trials and accelerates the development of your product and speed to market distribution.

To provide information for public health or public policy purposes, a larger long - term trial targeting individuals with marginal vitamin A status is needed.

He contributes to other large - scale clinical trials including SAVE (evaluating whether treatment of obstructive sleep apnoea with continuous positive airways pressure can reduce the incidence of serious CV events in patients with established CVD), and CREDENCE, a randomised, double - blind, placebo - controlled trial assessing whether canagliflozin can slow the progression of diabetic nephropathy in patients with type 2 diabetes.

It's also a game that became dangerous for me when it introduced online rankings, as I could not stop playing once I noticed where I ranked in North America on time trial courses from the Wii edition — it was that experience with the time trials mode from my youth all over again, except instead of just besting myself and my dad and a couple of friends, it was a large percentage of a continent that I'm embarrassed to even quote here as it will give away just how time I spent with the game.

Three years of brilliant performances make Jones the 100 - and 200 - meter favorite at the trials, especially with Miller — who has not looked sharp in recent European races — saying last week that she is running merely to make the team in Sacramento, with victory in Sydney as her larger goal.

Hoeness, the larger - than - life club president, goes on trial in 2014 for tax evasion and the media is currently awash with stories of the «Bayern mole» — the insider who leaked Guardiola's line - up and tactical plans to Bild newspaper on the eve of November's top - of - the - table trip to Dortmund.

The large LEAP trial saw that exposure beginning anywhere from 4 — 11 months old was associated with a lower risk of peanut allergy.

One large trial in patients with heart disease showe d that supplementing with 1 gram of omega - 3 per day reduced their risk of death by 20 %.

The program of prenatal and infancy home visiting by nurses described above produced treatment - control differences in 15 - year - olds» arrests and reductions in arrests and convictions among 19 - year - old females.32, 33 In a subsequent trial with a large sample of urban African - Americans the program produced treatment impacts on 12 - year - olds» use of substances and internalizing disorders.34

The largest randomized trial of a comprehensive early intervention program for low - birth - weight, premature infants (birth to age three), the Infant Health and Development Program, included a home visiting component along with an educational centre - based program.7 At age three, intervention group children had significantly better cognitive and behavioural outcomes and improved parent - child interactions.

The protective effects of breast feeding have been shown to be dose responsive16 17 18 and minimal breast feeding may not be protective.17 Researchers in lactation have advocated that research on promotion of breast feeding must target exclusive breast feeding, 19 and ours is one of the larger randomised controlled trials with this primary outcome.

«This is the largest randomized trial of any behavioral intervention in children with autism spectrum disorder, and it shows that parent training works,» notes Lawrence Scahill, MSN, PhD, professor of pediatrics at Marcus and Emory School of Medicine, who directed the study.

The researchers point out that this is the largest randomised controlled trial of probiotic intervention in infants with colic to date.

In meta - analyses with a large number of trials, as is the case in this review, there is a strong possibility that a large number of small and possibly poor quality trials will have a substantial influence on the result.

The primary outcome with the largest difference in this sensitivity analysis was preterm birth, where an analysis restricted to trials with lower risk of bias suggested a larger treatment effect: RR 0.64, (95 % CI 0.51 to 0.81) compared with RR 0.77, (95 % CI 0.62 to 0.94) in the overall analysis.

For three analyses (Analysis 1.1 regional analgesia, Analysis 1.2 caesarean delivery and Analysis 1.16 episiotomy) there was a some suggestion of asymmetry, though in all cases this was due to two small trials with large treatment effects in the same direction (Figure 3; Figure 4; Figure 5).

COIB's announcement of the fines, and Stringer's scrutiny of Department of Correction spending, comes the same day that a jury is reportedly deadlocked in the corruption trial of former correction union president Norman Seabrook, who is accused of making a deal with a hedge fund to pocket $ 60,000 in exchange for agreeing to steer union money into the fund, which has since been revealed as one of the largest Ponzi schemes in recent memory.

To help make the case, the borough president worked with New York Waterway, one of the city's largest private fast ferry providers, to run trial routes at various alternative locations.

He told reporters the trial of Governor Cuomo's closest aide, Joe Percoco, going on inside the courthouse, is revealing that Cuomo presided over a pay to play culture in his office, where large donors to his campaign were rewarded with special favors.

He said the trial of Cuomo's former aide, Joe Percoco, going on inside the courthouse, is revealing that Cuomo presided over a pay - to - play culture in his office, where large donors to his campaign were rewarded with special favors.

He told reporters the trial of Governor Cuomo's closest aide, Joe Percoco, going on inside the courthouse, is revealing that Cuomo presided over a pay - to - play culture in his office, where large donors to his campaign were rewarded with special favors.

The trial lawyers, who had a close relationship with former Assembly Speaker Sheldon Silver, employ their own small army of top lobbying firms and spent a combined $ 687,700 on campaign contributions in 2015, making their organization, the New York State Trial Lawyers Association, the second largest donor in the strial lawyers, who had a close relationship with former Assembly Speaker Sheldon Silver, employ their own small army of top lobbying firms and spent a combined $ 687,700 on campaign contributions in 2015, making their organization, the New York State Trial Lawyers Association, the second largest donor in the sTrial Lawyers Association, the second largest donor in the state.

They may have done a thesis with a translational focus, but few will have received training in the requirements for doing modern patient - oriented research, which includes large doses of epidemiology, statistics, and human - subject trial design.

Advanced Cell Technology is now planning a larger trial, first in 100 people with Stargardt's, then in people with macular degeneration.

First, you will have to do the trial with a large number of people.

Yanagisawa believes a simple amyloid blood test would enable recruitment for clinical trials of new drugs in a larger share of the population, as opposed to only those with access to advanced academic centers.

It is worth noting at this point that this is not yet another case of a drug entering the market only to be withdrawn later because of lack of efficacy or even adverse reactions which could have been noticed with longer or larger trials.

Running a large clinical trial requires good skills in communication as you will have to work with many people and many organisations.

The investigators mined genetic data from large clinical trials to find individuals with naturally occurring mutations in the NPC1L1 gene that completely shut it down.

From here, we'll be optimizing the delivery system, evaluating the approach in more severe models of DMD, and assessing efficiency and safety in larger animals with the eventual goal of getting into clinical trials.»