CONCLUSION: In
this Lewy body variant case, with globally stable functional and cognitive features, Abeta immunization resulted in a significant clearance of amyloid deposits, with remaining tau and synuclein pathological features in the brain.
OBJECTIVE: To describe the neuropathological and biochemical findings of the brain examination of a patient enrolled in the AN - 1792 (QS - 21) trial with an initial clinical diagnosis of Alzheimer disease (AD), in whom
Lewy body variant was thereafter clinically diagnosed.