Like gene mapping, part of the reason for this evolution is the dramatic advances in information technology in recent years.
Not exact matches
By tracking activity in almost all the
genes of a free - living archaeon — which,
like a bacterium, is a prokaryote — Bonneau was recently able to piece together how the
genes affected one another's expression, enabling him to
map the organism's «control circuit» as if it were a machine.
Finally, the authors addressed two major challenges for any study that generates large data - sets of individual
genes and proteins in model organisms
like yeast: How to assemble the data into coherent
maps?
«Interactomes
like this one make the whole debate of
genes versus the environment a lot more sophisticated,» adds Vidal, who was not involved in the current study and who
mapped a network involved in breast cancer susceptibility in 2007.
And the shared
map implies that
genes for important characteristics, such as disease resistance, photoperiodism, drought tolerance, storage proteins and the
like, can be plucked direct from one genome and applied in another.
«First, there is no single road
map to eusociality — the complex, cooperative social system in which animals behave more
like superorganisms than individuals fending for themselves,» said
Gene Robinson, a lead on the study who is a professor of entomology and director of the Carl R. Woese Institute for Genomic Biology at the University of Illinois.
WHAT HE»S DOING NOW: ISB focuses on «big science» projects
like mapping the
genes of families prone to prostate cancer.
The new dependency data complement the Dependency
Map team's ongoing efforts to use functional genomic technologies
like CRISPR and RNA interference (RNAi) to locate vulnerabilities that arise within cancer cells as they compensate for the loss of critical
genes due to mutations or expression changes.
More recently, geneticists
like Bohlender have begun
mapping modern man's
genes and comparing them to what we know of those who preceded us.
Their objective is to
map the interactions among the 65 proteins those
genes code for and chart the networks between proteins,
like drawing constellations out of stars in the sky.