Sentences with phrase «like tumor cells»

These serial tumor transplantation experiments and replating assays provide concrete experimental evidence that PC3 holoclones contain stem - like tumor cells that could initiate serially transplantable tumors.

Although some tumors may be formed by initiating cells that do not resemble stem cells, it is likely that stem cell — like tumor cells are more aggressive at forming tumors, with a higher likelihood of relapse and metastasis.

Rare stem - like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, report University of California San Diego School of Medicine and Moores Cancer Center researchers.

Using tumor samples from the Women's Healthy Eating and Living clinical trial, researchers identified stem - like tumor cells as being characterized by low levels of the molecule p53 upregulated modulator of apoptosis (PUMA).

Like tumor cells, fetal cells are foreign to the body.

A rare - stem like tumor cell, which plays a critical role in the spread of breast cancer, is identified with immunostaining for the?

Not exact matches

They did so by including factors like the mechanical forces acting on the cells and the tumor's cellular heterogeneity.

But the next big question was whether these cells could home in on tumors in lab dishes, and in animals, like neural stem cells.

Furthermore, while the approach has shown tremendous promise in treating blood - based cancers like leukemia, solid tumors remain stubbornly difficult to treat with CAR T cells.

«It was really surprizing to realize that oncogenic Pik3ca in basal cells induced the formation of luminal tumours, while its expression in luminal cells gave rise to heterogeneous and more aggressive tumors including basal - like tumors,» comments Alexandra Van Keymeulen, the first author of the paper.

«This explained why they did not persist: The induced tumor behaves like a sink for these T cells.

«Just as normal cells with the same genome differentiate into many different cell types, a single tumor characterized by specific genetic mutations can contain many different types of cells — stem - like and more differentiated cells — with the difference being rooted in their epigenetic information.

They found that the tumor cells produce a protein that acts like Velcro to attach the cells to the outer wall of a blood vessel.

For some cancer patients, viruses engineered to zero in on tumor cells work like a wonder drug.

There is currently a PD - 1 antibody on the market that blocks T cell exhaustion in patients with solid tumors, like lung cancer and melanoma.

Testing each of these factors for their ability to return differentiated tumor cells to a stem - like state, identified a combination of four — POU3F2, SOX2, SALL2 and OLIG2 — that was able to reprogram differentiated tumor cells back into glioblastoma stem cells, both in vitro and in an animal model.

If we can boost the immune system and allow microglia to do their job and control brain tumor stem cells, it would be like removing the seed from the soil — stopping the tumor growth before it starts to get out of control.»

Like all cancer vaccines, it's been a challenge to get dendritic cell immunotherapy to destroy tumors in people.

These cancer stem cells act like the seeds of cancer and are responsible for re-growing a tumor after therapy.

«We're still trying to figure out why these anti-tumor T - cells don't go into pancreatic tumors like they do for other malignancies,» Beatty said.

Metastatic cancer cells have the ability to break free from tissue, circulate in the blood stream, and form tumors all over the body, in a way acting like blood cells.

Compared to a control (left), epalrestat treatment (right) reduces the number of metastatic tumors (arrowheads) in the lungs of mice injected with human basal - like breast cancer cells.

With a less efficient helicase and therefore less efficient DNA repair, Martin suggests, atherosclerotic lesions could arise like tumors from mutations in single cells, besides their well - known origin from chronic inflammation from high - fat diets.

Devils bite each other on the face as they scrabble, and malignant cells can crumble off tumors like feta cheese, dropping into bite wounds.

Their stem cell - like properties enable them to maintain a pool of cancer stem cells within the tumor, as well as to produce new mature tumor cells.

Increasing levels of PUMA only affected stem - like cells that were starting to spread and not the growth of primary tumors.

Techniques like that may lead to novel therapies while avoiding the primary downfall of stem cell therapies: the development of tumors.

«While these tumors appear to be muscle cells under the microscope, and clinicians had thought that they arose from muscle progenitor cells, that didn't explain why the tumors can occur in tissues that don't have skeletal muscle, like bladder, prostate and liver,» he continued.

«We need to get the [tumor] stem cells to grow in an environment much more like a patient's brain,» he said.

Tumor cells associated with pancreatic cancer often behave like communities by working with each other to increase tumor spread and growth to different orTumor cells associated with pancreatic cancer often behave like communities by working with each other to increase tumor spread and growth to different ortumor spread and growth to different organs.

Another is that the transplanted bits of tumor act nothing like cancers in actual human brains, Fine and colleagues reported in 2006: Real - life glioblastomas grow and spread and resist treatment because they contain what are called tumor stem cells, but tumor stem cells don't grow well in the lab, so they don't get transplanted into those mouse brains.

Drugs like pembrolizumab boost the response in tumors where immune cells are present but don't work in tumors where there is no immune response to boost.

Sentinel nodes are the first lymph nodes to which cancer cells from a primary tumor like melanoma will spread.

Checkpoint inhibitors like ipilimumab — which has been on the market since 2011 — nivolumab, and pembrolizumab stop tumor cells from stimulating the receptors.

Inhibition of transcription (blockade of water) on tumor suppressor genes, such as p21, leads to cell transformation (growth of the cactus - like eremophytes instead of normal plants from the drought).

Like cells in all cancers, the B cells begin to grow out of control, creating tumors in the lymph nodes, spleen or other tissues.

Drugs like fluorouracil, oxaliplatin and irinotecan work by mimicking and damaging DNA molecules, or inhibiting enzymes involved in cell and DNA replication, slowing the uncontrolled growth of tumor cells.

We found that geometric constraints, like you would have where a tumor touches healthy tissue, seem to activate these cancer stem cells at the perimeter.»

«In principle, both these features make GA11 an attractive drug candidate to target glioma stem - like cells in glioblastoma multiforme tumors,» said Ichiro Nakano, M.D., Ph.D., and colleagues in the paper.

«We found that these cells were like little time bombs, hiding from the chemotherapy and then later initiating tumor growth,» Memarzadeh said.

In their study published online May 9 in the journal Oncogene, scientist Saraswati Sukumar, Ph.D.; her graduate student Wei Wen Teo; and their colleagues show that cells without HOXA5 have an increased capacity to renew themselves and are more invasive than normal breast cells — in short, they become more tumor like.

«These slow - growing cells are apparently kept in check by the rest of the tumor, somehow — indeed, if you remove them from a tumor, they grow like crazy.»

«In this case, the pathway involved the loss of a protein called MBD3 that allows tumor cells to become more like stem cells and persist,» said first author on the study Rakesh Verma, a postdoctoral associate in hematology.

Singlet oxygen tends to rip apart tumor cells in a manner that exposes many new tumor antigens to immune cells called dendritic cells, which, like police executing a dragnet, grab the antigens and present them to T cells for closer inspection.

Much like metastasizing tumor cells, the team found, the fibroblasts can wriggle through the cells that line and protect blood vessels.

At the same time, other switches get flipped throughout the body, modifying everything from metabolism to cell growth, via other cytokines, such as IL - 6 and tumor necrosis factor — a, and things like CRP, which mark bacteria for destruction.

In the process they induce inflammation; the cells also secrete other inflammatory chemicals, like interleukin - 6 and tumor necrosis factor - alpha, which are known to adhere to the endothelium of the blood vessels, an early event in atherosclerosis.

Surgeons will monitor a traffic light - like video display as they cut, he explains, with red indicating tumor cells, green healthy tissue, and yellow something in between.

The tumor becomes differentiated, its cells now cyst - like and filled with fluid that contains, among other things, milk proteins.

About two - thirds of people with the germinal center subtype live for five years or more after diagnosis, while those with activated B - cell - like tumors have a poorer prognosis with current treatment regimes.