Limbal epithelial stem cells sheets cultured on amniotic membranes for treatment of limbal stem cell deficiency (LSCD).
Limbal epithelial stem cells (LESCs) reside in the basal layer of the limbal area, at the vascularised junction between the corneal and conjunctival epithelium.
Not exact matches
Initial reprogramming efforts used adult mouse
limbal progenitors (
epithelial cells which express Sox2, Klf4, and Myc) which the group reprogrammed to iPSCs using embryonic
stem cell CM (ESCM) supplemented with MAPK and GSK3 inhibitors as previously described [4, 5].
Researchers demonstrate that autologous oral mucosal
epithelial cells expanded under good manufacturing practice requirements can reverse
limbal stem cell deficiency in injured eyes up to 24 months, representing an advance in ocular tissue regeneration and transplantation
Existence of slow - cycling
limbal epithelial basal
cells that can be preferentially stimulated to proliferate: implications on
epithelial stem cells.