Sentences with phrase «lopinavir plasma concentrations»

The plasma concentration of pethidine in the infant is almost as high as that in the mother, reaching a maximum after 2 - 3 hours, after which the level falls slowly.

Nicotine is present in milk in concentrations between 1.5 and 3.0 times the simultaneous maternal plasma concentration, 15 and elimination half - life is similar — 60 to 90 minutes in milk and plasma.7 There is no evidence to document whether this amount of nicotine presents a health risk to the nursing infant.

Oxprenolol placental transfer, plasma concentrations in newborns and passage into breast milk.

Indeed, babies fed higher levels of breast milk show higher plasma concentration levels of DHA and AA in the brain cortex, cerebral grey and white matter, as well as a higher IQ up to 15 years of age compared to babies fed formula not containing LCPUFA.

Effects of feeding regimen on blood glucose levels and plasma concentrations of pancreatic hormones and gut regulatory peptides at 9 months of age: comparison between infants fed with milk formula and infants exclusively breast - fed from birth

Blood plasma concentrations of naloxone were measured nineteen times for each volunteer during each treatment session, with intense sampling in the first 15 minutes after dosing.

«A higher plasma concentration of these proteins means that there has been greater damage of muscle fibres and, therefore, a greater probability of fatigue.

The plasma concentrations of apoproteins B - 100 and E, the two ligands for the LDL receptor, declined by more than 90 percent after cadmium treatment, but the concentration of another apoprotein, A-I, was unaffected.

We estimated the DV for each voxel, which corresponds to the equilibrium measurement of the ratio of the radiotracer's tissue concentration to that of its plasma concentration using a graphical analysis technique for reversible systems (38).

The effects of aspirin on platelet function and lysophosphatidic acids depend on plasma concentrations of EPA and DHA.

Indeed it did, with CSF concentrations reaching about 0.3 % of plasma concentrations at any given dose of the antibody.

Liposuction did not significantly alter the insulin sensitivity of muscle, liver, or adipose tissue (assessed by the stimulation of glucose disposal, the suppression of glucose production, and the suppression of lipolysis, respectively); did not significantly alter plasma concentrations of C - reactive protein, interleukin - 6, tumor necrosis factor alpha, and adiponectin; and did not significantly affect other risk factors for coronary heart disease (blood pressure and plasma glucose, insulin, and lipid concentrations) in either group.

The levels of ciprofloxacin in surface water around the Indian plant exceeded human therapeutic blood plasma concentrations, and were thus presumably toxic for a wide range of bacteria.

We therefore conducted a cross-sectional analysis to investigate the relations between magnesium intake and plasma concentrations of inflammatory and endothelial biomarkers, including CRP, IL - 6, soluble TNF - α receptor 2 (sTNF - R2), E-selectin, soluble intercellular adhesion molecule 1 (sICAM - 1), and soluble vascular cell adhesion molecule 1 (sVCAM - 1) in apparently healthy women.

Plasma concentrations of biomarkers of inflammation and endothelial dysfunction by quintile (Q) of dietary magnesium intake in 657 apparently healthy women in the Nurses» Health Study1

Inverse associations were consistently observed between dietary magnesium and plasma concentrations of CRP and E-selectin after adjustment for age, BMI, physical activity, smoking status, alcohol consumption, and use of hormone replacement therapy.

Age - adjusted geometric mean plasma concentrations of CRP, E-selectin, and sICAM - 1 trended toward significant decreases with increasing quintiles of magnesium intake (P for linear trend = 0.003 for CRP, 0.001 for E-selectin, and 0.03 for sICAM - 1)(Table 3).

Elevated plasma concentrations of soluble forms of endothelial adhesion molecules, released from shedding or proteolytic cleavage from the endothelial cell surface, are considered useful indicators of endothelial dysfunction and activation (20, 25).

In fact, one double blind, placebo - controlled study found that after seven weeks of supplementing, creatine ethyl ester resulted in less creatine in the muscles and blood than regular monohydrate, plus it appears to lead to higher plasma concentrations of the byproduct creatinine.

Blood was sampled frequently at the end of each diet phase to measure the area under the plasma concentration versus time curve (AUC) for insulin, leptin, and ghrelin.

No significant differences were observed in fasting plasma concentrations of free fatty acids, glucose, or insulin measured during visit CRC1, CRC2, or CRC3 (Table 6).

The isocaloric high - protein diet led to no significant change in nadir plasma concentrations, peak plasma concentrations, or AUC values for the 24 - h leptin profiles obtained during CRC2 compared with those obtained during visit CRC1.

This will temporarily dilute blood plasma concentrations of leucine and other regulatory amino acids, triggering autophagy to the point where the original equilibrium of regulatory amino acids is restored.

Bioavailability determinations based on the peak plasma concentration can be misleading, because drug elimination begins as soon as the drug enters the bloodstream.

Endothelial function assessed by flow - mediated vasodilation and plasma concentration of 8 - isoprostanes were measured at baseline and at 1 and 2 h after coffee intake.

The drop in blood pressure was associated with the highest blood plasma concentration of phenolic compounds, particularly vanillic acid and protocatechuic acid.

We found that higher intakes of non-HVOs are independently associated with lower plasma concentrations of some inflammatory markers.

After control for potential confounders, women in the highest quintile of PHVO intake had higher plasma concentrations of C - reactive protein (CRP; percentage difference from lowest quintile: 45 %; P for trend: < 0.01), tumor necrosis factor - α (TNF - α; 66 %; P for trend: < 0.01), interleukin - 6 (72 %; P for trend: < 0.05), and soluble intercellular adhesion molecule - 1 (sICAM - 1; 22 %; P for trend: < 0.01) than did women in the lowest quintile.

In conclusion, our findings indicated that higher intakes of PHVOs were associated with elevated concentrations of inflammatory biomarkers, whereas higher intakes of non-HVOs were associated with lower plasma concentrations of these biomarkers.

Multiple linear regression analysis with log - transformed plasma concentrations of inflammatory markers as dependent variables and dietary intakes of PHVOs and non-HVOs as independent variables (all as continuous) were used.

Consumption of PHVOs was associated with higher plasma concentrations of sICAM - 1, either before (percentage difference between top and bottom quintiles in crude model: 28 %; P for trend: < 0.01) or after adjustment for confounders (percentage difference between top and bottom quintiles in model 2: 22 %; P for trend: < 0.01)(Table 4).

Consequently, the plasma concentration of free fatty acids begins to rise within minutes.

Blomstrand, E., Hassmen, P., Ekblom, B., and Newsholme, E. A. Administration of branched - chain amino acids during sustained exercise — effects on performance and on plasma concentration of some amino acids.

This diet is also used to help people who already have type II diabetes as fiber helps «improve glycemic control, decreases hyperinsulinemia, and lowers plasma concentrations» (24).

A similar association is revealed between increased IGF - 1 levels and breast cancer «The results of this collaborative analysis show that plasma concentrations of IGF1 are positively associated with breast - cancer risk.»

* Clinical research shows that Meriva supplementation results in higher plasma concentrations of curcumin from a much smaller amount than with ordinary curcumin.

Citrulline - malate ingestion significantly increases the plasma concentration of citrulline.

«CHO [carbohydrate] and CHO+VC significantly blunted the post-exercise increase in plasma concentrations of cortisol, ACTH, total leukocyte, and neutrophil counts and limited the decrease in plasma glucose concentration and bacteria - stimulated neutrophil degranulation.»

Diets high in protein or saturated fat do not affect insulin sensitivity or plasma concentrations of lipids and lipoproteins in overweight and obese adults.

Plasma concentrations of the psychoactive THC increased equally in the vaporising and smoking groups.

Their plasma concentrations of THC were measured along with exhaled levels of carbon monoxide (CO), a major pollutant from marijuana smoke.

In rats, peak plasma concentration was found 30 minutes after oral dosing.

Goldin and coworkers (1982) reported decreased plasma concentrations of estrone and increased fecal excretion of estrogens with increasing fecal weight.

With less reabsorption of estrogens, plasma concentrations decrease.

Furthermore, this powerful mineral directly reduces skin inflammation by lowering the plasma concentrations of C - reactive protein, a protein connected to the inflammation process within your body.

Astrup and coworkers (1990) showed no effect of the addition of 30 g / d of plant fiber to a very low energy diet on plasma concentrations of magnesium.

Hustead, V. A., Greger, J. L., and Gutcher, G. R. Zinc supplementation and plasma concentration of vitamin A in preterm infants.

Psyllium decreased plasma concentrations of total cholesterol by 5.6 percent and LDL cholesterol by 8.6 percent; concentrations were unchanged in the cellulose group.

The baPWV significantly decreased (from 1,202 ± 105 to 1,074 ± 110 cm · s − 1) and the plasma NO concentration significantly increased (from 20.4 ± 6.9 to 34.4 ± 17.2 μmol · L − 1) after SMR using a foam roller (both p < 0.05), but neither significantly differed after CON trials.

Oral vitamin C produces tissue and plasma concentrations that the body tightly controls.