Sentences with phrase «lower number of possibilities»

Lower number of possibilities but lower competition, the other months.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

With an even number of justices, while majorities may be more «statistically significant», the 3rd possibility of a tie means the Lower Court prevails but each District can continue doing their own thing.

Only 35 percent reported an ECG in the previous year and 46 percent said they had an ECG in the previous five years, reducing the possibility that the low number of cardiac events stemmed from at - risk runners being screened out before the race.

It is not all that earthshaking that the numbers in Schmittner et al come in a little low: the 2.3 ºC is well within previously accepted uncertainty, and three of the IPCC AR4 models used for future projections have a climate sensitivity of 2.3 ºC or lower, so that the range of IPCC projections already encompasses this possibility.

In fact, inflammation and other disorders are known to decrease IGF - 1 levels, raising the possibility that the low protein and low IGF - 1 group may contain a significant number of both malnourished and frail individuals having or in the process of developing major diseases (Fontana et al., 2012).»

The SUV will compete with the likes of the Renault Duster, Hyundai Creta and Nissan Terrano but there is also the possibility of the car cannibalising sales of its sibling, the S - Cross, which is already selling in very low numbers.

These are some of the reason I believe are contributing to the low number of TFSA accounts being opened, Jonathan points out that the tax refund season may bring in a new wave of TFSA accounts being opened I believe that is a good possibility.

When the room price is low, the number of points needed to book it is also lower, so there's a possibility to maximize the sign - up bonus by traveling in the off - season.

Despite knowing little about what direction the developers will take Tales» debut on the Switch, narrowing the likely options is a possibility due to the relatively low number of titles that would make sense for Bandai Namco and the series.

- the game's shading mechanism has changed, which allows for increased gear texture quality - all graphical aspects and programming mechanisms have been built up from scratch for this sequel - maximum resolution is 1080p in TV mode - a bigger focus for Nintendo was the 60 frames per second - occasionally the resolution will be scaled down when there is too much ink displaying on the screen - Nintendo reduced the CPU load and refined the way to use CPU power effectively to maintain 60 fps in all matches - weapons were tweaked to let players be more creative by thinking about unique weapon characteristics and their best uses - weapons are designed to be effective when they are used during the right occasion - Special weapons are stronger than the original ones when used in the right situation, but weaker otherwise - the damage and effect of slowing down your movement when you step in the opponent's ink are reduced from original - you can jump up in rank if you're good enough, but only up until S - you can't jump up from C, B or A to S + - when you win battles in Ranked mode, the Ranked meter fills and your rank goes up when its fully filled - when you lose a battle, the gauge does not decrease, but the meter starts to crack - once the meter reaches its limit, it breaks - when the meter breaks, you have to start over again from the beginning or from a lower rank - highest rank is still S +, but if you fill up the Ranked meter, you get numbers after the alphabet such as «S +1», «S +2» and so on - maximum number is «S +50», but this number will not be displayed to your opponent - you are the only one to see it, and you can check it on your own status screen - Ranked Power is calculated by an algorithm to measure how strong each player is with minuteness - this will determine if a player's rank is worthy of receiving a big jump (like from «C» to «A»)- Ranked Power has no relation to your splat rate, and is more tied into to how well you lead your team to victory - you won't drop off more than one rank even if you play poorly - stage rotation time was changed to two hours - this was done because the devs expected people to play for an hour or so, but they found people play much longer - with Salmon Run, Nintendo considered how to implement a co-op oriented mode in a player - versus - player type of game - the devs will monitor how users are playing this mode to see if there's some tweaks they can throw in - more Salmon Run maps will be added in the future, but Nintendo wouldn't comment on adding more enemy types to the mode - rewards are changed each time Salmon Run is played - you can obtain rewards when playing locally, but not gear - originally Nintendo had an idea for this mode, but had no background setting, enemy designs, etc. - Inoue suggested that it should be salmon - themed - when Nintendo hosted the Splatfest that pit Callie against Marie, the development of Splatoon 2 had started - the devs had already decided to have the result reflected in the sequel - they even had an idea to announce the Splatfest with a phrase «Your choice will change the next Splatoon» - the timing to announce a sequel wasn't right, so they decided against this - they eventually released a series of short stories about the Squid Sisters to show how the Splatfest affected the sequel's story - Nintendo wouldn't say if Marina is an Octoling, and noted that Inklings are not paying attention to this too much - Inklings don't care about appearances, as long as everyone is doing something fresh - the Squid Sisters had composers who produced their songs, but Off the Hook are composing their music by themselves - Pearl is genius artist, but she couldn't find a right partner because she's a bit too edgy - she eventually found Marina as a partner though, and their chemistry is sparkling right now - Nintendo is planning a year of content updates for Splatoon 2 - when finished, the quantity of stages will be more than the original - some of the additional stages are totally new and some will be arranged stages from the first game - not all original stages will return and they are choosing stages based on the potential for them to be improved - Brella is shotgun-esque weapon, so the ink hits your opponent more if you are closer - it can shield damage when you open it, but the amount of damage has a limit and once it reaches it, it breaks - you can shoot ink, but you can't use the shield feature when it breaks - the shield won't prevent your allies ink - there are more new weapon categories which haven't been revealed yet - there are no other ranked modes outside of the three current options - the future holds any sort of possibility, but the devs didn't get specific about adding more content like that - for the modes, they adjusted the rule designs so that players will experience the more interesting aspects

Creatures When dropping Toki in a nest, birds now have a «cooldown», so they won't instantly pick you up again when walking out of the nest Birds don't stop anymore when they sense vibration, making them less annoying when accidentically stomping near them No more random sorting of creatures: they all appear on their assigned depth value, preventing smaller creatures from sometimes getting lost behind bigger creatures Fixed the «spawning multiple camera birds» bug Slug corpses can't kill anymore, so no more accidentally walking into them and dying Bugs When stomped, berrybugs and copybugs now always hop the same distance (3 tiles), making their behavior more predictible Berrybugs now briefly stop if they detect an edge above their heads while walking on the floor, making it easier to stomp them onto a wall Copybugs and berrybugs get stunned when they're in the trajectory of a to be spawned bubble, so they can't hop / roll away before bubble is spawned Glowy berrybugs now use the same turn animation as normal berrybugs, so no more faster glow bugs Frogs and bubbles Bubbles now prioritize Toki Tori over other entities, so no more accidental berrybug ballooning Added a small delay before catching an entity in a bubble to allow for catching Toki Tori, even if he's a little further away than an entity Added possibility to queue a «turn by whistle» while the frog is running towards a berrybug, so you don't have to wait before being able to let the frog face the desired direction Fixed a problem where a fat frog won't belch anymore Achievements In - menu achievements system, including progress achievements Added a number of new achievements Tokidex completion is now a progress achievement (you can see how far along you are) Fixed the Fried Chicken achievement, so it's less hard to get All electrocuted entities now count for the X-Ray Enthusiast achievement Menu Completely new, streamlined and fast to access menu system Ability to set language from menu New font Graphics Improved presentation of telepathic Ancient Frog messages, fixed a problem where sometimes they'd spawn multiple times Fixed black flickering when buttonbashing during fades and level transitions Screenfades are now 100 % black Added button prompts to the first time you need to use whistle and stomp Areas and puzzles Added l - ife area for Ife < 3 Added an extra landing stone in the wasteland area Added more snow globes: — RRB - Water mountain approach: berrybug in the «pro» puzzle can no longer be lost Water mountain top: frog for Ancient Frog puzzle now starts bloated, added light to make «pro» puzzle easier to execute Shaft top: Small tweak to make sure berrybug isn't killed by the slugs midway through the level Water cave: made the light shaft where you need to whistle the hermit crab a bit wider, created hole for frogs at end of level to prevent them from falling down, made some «pro» puzzles a bit more forgiving Dark forest: lowered warp when entering dark area, so it's easier to travel up with a bubble Lava cave: improved bat puzzle Meadow: made some pro puzzles less difficult Hideout: removed alternative solution for Ancient Frog puzzle Descent: made it easier to pick up fat frog at beginning

And a growing number of marine species are reaching the precariously low levels where extinction is considered a real possibility.

Last December, the Association of Chief Police Officers (ACPO) recommended a suspension of low copy number DNA analysis in criminal cases after a judge in the trial of the alleged Omagh bomber expressed concern at the scientific validity and possibility of cross-contamination of the technique.

The number of studies exploring the association between cortisol in saliva and markers for inflammation is low, which limits the possibility of interpretation.