Sentences with phrase «lymphocyte signalling»

The successful applicant will join the laboratory of Dr Rahul Roychoudhuri within the Lymphocyte Signalling and Development ISP.

Not exact matches

Although GMCSF is mostly known for its role in inflammation, Dr. Merad's laboratory discovered that GM - CSF is produced in the normal gut by specialized cells called innate lymphocyte cells (ILCs) in response to microbiota signals.

In lymph nodes, a particular type of stromal cells that forms a scaffold for lymphocytes to crawl around within the node normally secretes an enzyme called autotaxin, which is responsible for the production of the lipid signaling molecule, lysophosphatidic acid (LPA).

The scientists have demonstrated that this highly potent signal is able to alert cells related to lymphocytes, group 2 innate lymphoid cells (ILC2).

Recently recruited to the Maisonneuve - Rosemont Hospital Research Centre, Christopher Rudd specializes in signaling mechanisms that control the immune function of T lymphocytes.

Signal transduction through the T - lymphocyte CD4 receptor involves the activation of the internal membrane tyrosine - protein kinase p56lck.

Dr. Shanker's expertise, leadership, and motivation to structure and direct the current research will uncover underlying mechanisms of lymphocyte crosstalk, along with their interface with neural signaling.

Cytotoxic T lymphocyte antigen - 4 accumulation in the immunological synapse is regulated by TCR signal strength.

Research Interests: Lymphocyte activation; Signal transduction; Membrane - cytoskeletal dynamics; Lymphoma; Autoimmunity; Inflammation.

The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF -[kappa] B signalling.

Regulation of PI -3-Kinase and Akt signaling in T lymphocytes and other cells by TNFR family molecules.

Title: Hes1 Is a Critical but Context - Dependent Mediator of Canonical Notch Signaling in Lymphocyte Development and Transformation Authors: Wendorff AA, Koch U, Wunderlich K, Wirth S, Dubey C, Brüning JC, MacDonald HR, Radtke F Date: November 2010 Publication Details: Immunity 18 Nov 2010; 33 (5): 671 - 84

We have used B. anthracis to study the effect of MAPK signaling pathways in group 3 innate immune lymphocytes (ILC3s).

Objective: To use innovative approaches of integrative biology to unravel how lymphocytes process an array of molecular signals arising from contact with dendritic cells, thereby better understanding the mechanisms that underlie immunity and how they are altered in disease states.

His laboratory at MGH postulated and provided evidence for the first ligand - independent signaling model during lymphocyte development, now a widely accepted mechanism for both pre-B receptor and pre-T receptor signaling.

My group has also shown that lymphocytes from patients with breast cancer, melanoma, and colorectal cancer develop immune signaling defects that blunt their proliferation and function in vivo.

Moreover, the researchers also discovered that the formation of normal B lymphocyte groups that produce antibodies to fight real infections is not dependent on interferon gamma signaling.

As this disease develops, antibodies recognize the thyroid tissue as being foreign and lymphocytes, a form of white blood cell, are signaled to cause the actual destruction.

The concept that the resting state in lymphocytes is maintained passively in the absence of stimulatory signals prevailed through the mid-1990s.