Sentences with phrase «map kinase pathway»

We further demonstrate that the cAMP - responsive enhancement of Oct4 activity is at least partially regulated through the p38 MAP kinase pathway.

p38 MAP kinase pathway regulates apoptosis through phosphorylation and up - regulation of BimEL: ProQuest.

Western blot analyses with phospho - specific antibodies suggested that stretching induces phosphorylation of ERK of the MAP kinase pathway, but did not induce phosphorylation of phosphatidylinositol 3 - kinase.

More importantly, Choudhury and colleagues found that DAZAP1 directly links the regulation of gene splicing with the MAP kinase pathway — a key signaling pathway that controls cell proliferation.

Half of all melanomas harbor an activating mutation in the BRAF gene that turns on the cancer signaling pathway in cells known as the MAP kinase pathway.

By analysing skin biopsies post-injection, the researchers found that the excessive inflammation was associated with activation of the p38 MAP kinase pathway.

Moreover, similarly to autonomous BaF3 harboring spontaneously acquired mutations, all JAK1 mutants induced the constitutive activation of STAT5 and MAP kinase pathways when ectopically expressed in BaF3 cells (Online Supplementary Figure S2B) for 8 representative mutants.

In contrast, all autonomous BaF3 clones showed constitutive activation of STAT5 and, for most of them, constitutive phosphorylation of JAK1 and ERK1 / 2 was also detected, confirming that all JAK1 - mutated autonomous clones harbored constitutive activation of the JAK - STAT and the MAP kinase pathways.

Not exact matches

The researchers from Halle have now figured out that the already familiar MAP kinase signalling pathway plays a central role.

Effect of Saturated Stearic Acid on MAP Kinase and ER Stress Signaling Pathways during Apoptosis Induction in Human Pancreatic ß - Cells Is Inhibited by Unsaturated Oleic Acid.

In the last decade the identification of genetic drivers of melanoma cell which regulate proliferation and survival - such as BRAF and other activators of the MAP - kinase pathway - along with the recent development of immunotherapy has taken away in many cases the invasive treatment of melanoma as an option.

Title: A genome - wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation (IN PRESS, Oct 2012) Authors: Sharrocks A, Yang S - H, Kalkan T, Haslam C, Smith A Date: IN PRESS, Oct 2012 Publication Details: PLoS Genetics

«By providing the first - ever plant map kinase mutant, it really opens up possibilities for genetic studies of the signaling pathways.»

The p38 MAP kinase signal transduction pathway is an important regulator of proinflammatory cytokine production and inflammation.

The notion that a Nanog positive, ICM - like population of high probability self - renewing cells is a developmental ground state is supported by the expansion of this state in the presence of a blockade on the major signalling pathways known to promote ES cell differentiation, the MAP kinase / ERK cascade and GSK3β [42], [50].

In contrast, loss of adhesion induced the phosphatases Dusp4 and -5 (Map - kinase phosphatases), which are inhibitors of the MAP - kinase signaling pathway, whereas contact inhibition induced the quiescent cell - specific transcription inhibitor E2Map - kinase phosphatases), which are inhibitors of the MAP - kinase signaling pathway, whereas contact inhibition induced the quiescent cell - specific transcription inhibitor E2MAP - kinase signaling pathway, whereas contact inhibition induced the quiescent cell - specific transcription inhibitor E2F4.