Sentences with phrase «mb microcircuit»
Importantly, activity of the sleep - promoting MB microcircuit is increased by sleep deprivation and is necessary for homeostatic rebound sleep (i.e., the increased sleep that occurs after, and in compensation for, sleep lost during deprivation).
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Our studies reveal the existence of two segregated excitatory synaptic microcircuits that propagate homeostatic sleep information from different populations of intrinsic MB «Kenyon cells» (KCs) to specific sleep - regulating MBONs: sleep - promoting KCs increase sleep by preferentially activating the cholinergic MBONs, while wake - promoting KCs decrease sleep by preferentially activating the glutamatergic MBONs.
These studies reveal for the first time specific functional connections between subsets of KCs and particular MBONs and establish the identity of synaptic microcircuits underlying transmission of homeostatic sleep signals in the MB.