Sentences with phrase «mdr1 gene product»

Pharmacologic treatment with ivermectin, loperamide, vincristine, and other drugs that are substrates of P - glycoprotein, the MDR1 gene product, may result in neurologic toxicosis in a high percentage of Collies.

We report that a synonymous SNP in the Multidrug Resistance 1 (MDR1) gene, part of a haplotype previously linked to altered function of the MDR1 gene product P - glycoprotein (P - gp), nonetheless results in P - gp with altered drug and inhibitor interactions.

Not exact matches

The product of the MDR1 gene, P - glycoprotein, is a large ATP - dependent transmembrane protein transporter found in the blood - brain barrier among other tissues.22 P - glycoprotein pumps substrates (e.g. ivermectin and loperamide) within the brain back into the blood.

Signs of ivermectin toxicosis can occur in any breed but are most common in ivermectin - sensitive breeds such as collies and other herding breeds.20, 21 Ivermectin sensitivity is derived from a frameshift deletion mutation of the multidrug resistance gene (MDR1; the most recent nomenclature is ABC ±), resulting in a severely truncated, nonfunctional protein product.

This product is probably an excellent choice for Collie or Australian shepherd breeds or other dogs that may have the MDR1 gene mutation.