Sentences with phrase «melk expression levels»

Given MELK is a cell cycle regulated genes, it would be important for the authors to test whether MELK expression levels in luminal and basal cell lines (Figure 4B) is correlated with their doubling time.

(A) MELK expression levels are significantly higher in breast carcinoma (n = 392, red circles) than in normal breast tissues (n = 61, blue circles) in the TCGA breast cancer cohort (Cancer Genome Atlas Network, 2012).

We found that the proliferation of MDA - MB - 468 cells expressing shMELK was restored, when the MELK expression level in these cells was rescued by expression of a shMELK - resistant allele of MELK (MELK - R)(Figure 5F, Figure 5 — figure supplement 3), confirming that the effects of shRNA are due to the specific knockdown of MELK.

Not exact matches

In five independent large cohorts in which more than 1100 total patients were followed for overall survival (Desmedt et al., 2007; Esserman et al., 2012; Kao et al., 2011; Pawitan et al., 2005; van de Vijver et al., 2002; Supplementary file 1), high expression level of MELK strongly correlated with increased rates of mortality (all p values < 0.05, hazard ratios > 2)(Figure 2D, Figure 2 — figure supplement 1D).

(B) Expression level of MELK tightly correlates with the pathological grade of breast tumors in the three independent cohorts for which these data are available.

In multiple independent breast cancer cohorts analyzed, we found a strong association of high expression levels of MELK with a higher grade of malignancy and an unfavorable prognosis regardless of the treatment modality.