MMPs cleave the peptides to liberate tiny reporter fragments, which are then filtered out by the kidney and concentrated in the urine, where they can be detected using various methods, including a simple paper - based test.
These particles congregate at tumor sites, where
MMPs cleave hundreds of peptides, which accumulate in the kidneys and are excreted in the urine.
Not exact matches
They connected the two magnetic materials with a linker that is naturally
cleaved by
MMP - 2.
To detect this sort of enzyme, the researchers designed nanoparticles coated with small protein fragments called peptides that can be
cleaved by particular proteases called
MMPs.
(b) The MRI signal is turned «ON» when the linker between the two magnetic materials is
cleaved by
MMP - 2.
(a)
MMP - 2 represented by little scissors is an enzyme that
cleaves the extracellular matrix and allows cancer to metastasize to other tissues.
However, in the presence of the cancer, the linker is
cleaved by
MMP - 2, which cause the two materials to be separated and the MRI signal switched «ON.»
Dr. Campisi has found instead that a minority of senescent cells evade destruction by secreting high levels of matrix metalloproteinases (
MMPs), which
cleave MICA / B ligands and thereby prevent NKG2D binding.