These functional maps had large heterogeneous activations, so we parsed them by structure in
MNI space to create a final set of functional masks using FSLView's Harvard - Oxford Cortical and Subcortical atlases.
This is entirely a function of the change from Talairach to
MNI space and the use of different atlases.
T1 - weighted structural images (voxel size = 1 mm isotropic) of each participant were used to coregister and normalise the functional images to
MNI space.
The neuroanatomic localization, boundaries, and contours were traced in
MNI space with precise correlation to the aforementioned datasets.
We found enhanced activity in the rostral anterior cingulate cortex [rACC;
MNI space coordinates (x, y, z): — 6, 41, 22; Z = 3.85; P < 0.0005] and medial orbitofrontal cortex (mObfc; 6, 49, — 19; Z = 3.42; P < 0.0005), ventral anterior cingulate cortex (vACC; 13, 32, — 14; Z = 4.56; P < 0.0005 uncorrected), and the vmPFC -LRB--- 4, 39, — 13; Z = 3.48; P < 0.0005).
Not exact matches
Specifically, the voxels corresponding to striatum (caudate, putamen, and ventral striatum) and thalamus were defined in the
MNI stereotactic
space using the Automated Anatomical Labeling atlas (41); thresholding, the simplest method of image segmentation, was used to identify midbrain voxels on a T1 - weighted image (ch2.img; an average of 27 T1 - weighted scans of the same individual that is included in the MRIcro template folder).
For the current study, these maps were then re-registered to the Montreal Neurological Institute (
MNI) standard
space [44].
Studies were included in our meta - analyses if the following criteria were given: (I) included at least one clinical group with described aggressive behaviour, (II) in combination with a healthy control sample, (III) conducted during adolescence, (IV) reported whole brain gray matter volume alterations or whole brain functional neuroimaging data, (V) results are described using a standard reference
space (Talairach or
MNI) and (VI) the same threshold was used throughout the whole brain analysis.
The realigned images were then normalized to the Montreal Neurological Institute (
MNI)
space (3 mm × 3 mm × 3 mm) and spatially smoothed with a Gaussian kernel (FWHM = 6 mm × 6 mm × 6 mm).